Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease.

Abstract:

:Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5- and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

authors

Hosoki K,Hirayama M,Kephart GM,Kita H,Nagao M,Uchizono H,Toyoda H,Senba Y,Imai Y,Komada Y,Ihara T,Fujisawa T

doi

10.1159/000337777

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

70-4

eissn

1018-2438

issn

1423-0097

pii

000337777

journal_volume

158 Suppl 1

pub_type

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