Smad3 regulates dermal cytokine and chemokine expression and specific antibody production in murine responses to a respiratory chemical sensitizer.

abstract：BACKGROUND:Elicitation of contact hypersensitivity requires antigen-specific immunoglobulin M (IgM) antibodies that trigger recruitment of effector T cells to the local tissue. These antigen-specific IgM antibodies are produced by B-1-like 'initiator B cells'. In this study, we compared susceptibility to hapten-induced...

journal_title：International archives of allergy and immunology

authors： Itakura A,Ikutani M,Takatsu K,Kikuchi Y

更新日期：2013-01-01 00:00:00

abstract：:Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...

journal_title：International archives of allergy and immunology

authors： Aron AL,Gharavi AE,Shoenfeld Y

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...

journal_title：International archives of allergy and immunology

authors： Zhu L,Zhuo L,Kimata K,Yamaguchi E,Watanabe H,Aronica MA,Hascall VC,Baba K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

journal_title：International archives of allergy and immunology

authors： Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study...

journal_title：International archives of allergy and immunology

authors： Kasahara TM,Bento CAM,Gupta S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor. OBJECTIVE:This study was undertaken to examine the direct effects of CysLTs on eosinophils, such as chemotaxis and degranulation, focusing on CysLT(1). METHODS:Eosinophils we...

journal_title：International archives of allergy and immunology

authors： Ohshima N,Nagase H,Koshino T,Miyamasu M,Yamaguchi M,Hirai K,Yamamoto K,Fujisawa T,Nakagawa N,Kishikawa K,Morita Y

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...

journal_title：International archives of allergy and immunology

authors： Hagan JB,Park MA,Kita H,Campeau NG

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Volatile monoisocyanates are formed through thermal degradation when products containing polyurethane are heated. Repeated exposure to diisocyanates, such as toluene diisocyanate (TDI) are a well-known cause of occupational asthma. However, although monoisocyanates are abundant in occupational settings, ther...

journal_title：International archives of allergy and immunology

authors： Svensson-Elfsmark L,Koch BL,Gustafsson A,Bucht A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Cytosolic phospholipase A2 (cPLA2) plays a key role in the development of late-phase anaphylaxis. L-Glutamine (Gln), a nonessential amino acid, has anti-inflammatory activity via inhibiting cPLA2. METHODS:We used a penicillin-induced murine model of anaphylaxis, and late-phase anaphylaxis was quantified by ...

journal_title：International archives of allergy and immunology

authors： Kim HK,Song CH,Bae YS,Im SY,Lee HK

更新日期：2016-01-01 00:00:00

abstract：:For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....

journal_title：International archives of allergy and immunology

authors： Lorenz AR,Luttkopf D,Seitz R,Vieths S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The so-called 'latex-fruit syndrome' is a well-documented phenomenon in cross-reactive allergies. By contrast, there is a lack of information about allergy to exotic fruits in patients with a predominant pollen sensitization. Since the ubiquitous protein profilin has been identified as an allergen in natural...

journal_title：International archives of allergy and immunology

authors： Reindl J,Rihs HP,Scheurer S,Wangorsch A,Haustein D,Vieths S

更新日期：2002-06-01 00:00:00

abstract：:The objective of this study was to investigate the role of progesterone in modulating electrophysiological responses to antigenic challenge that are reflective of immune functions in uterine and jejunal mucosae. In the rat-Trichinella spiralis, host-parasite system, an enteric infection with a microscopic nematode sen...

journal_title：International archives of allergy and immunology

authors： Harari Y,Castro GA

更新日期：1995-10-01 00:00:00

abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

journal_title：International archives of allergy and immunology

authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

更新日期：2021-01-27 00:00:00

abstract：:Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast...

journal_title：International archives of allergy and immunology

authors： Bischoff SC,Sellge G

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Galectin-9 was recently identified as a ligand for Tim-3, which negatively regulates Th1 cells. Here, we investigated whether administration of anti-galectin-9 antibodies (Abs) affects the development of murine experimental allergic conjunctivitis (EC), a Th2-mediated disease. METHODS:EC was induced in BALB...

journal_title：International archives of allergy and immunology

authors： Fukushima A,Sumi T,Fukuda K,Kumagai N,Nishida T,Okumura K,Akiba H,Yagita H,Ueno H

更新日期：2008-01-01 00:00:00

abstract：:At an international hereditary angioedema (HAE) expert meeting, results from a survey were used to guide discussion on how best to advise patients on self-administering intravenous C1 esterase inhibitor therapy. Treatment differences across Europe were highlighted, together with the practicalities of self-administrati...

journal_title：International archives of allergy and immunology

authors： Symons C,Rossi O,Magerl M,Andritschke K

更新日期：2013-01-01 00:00:00

abstract：:Many different mediators have been implicated in allergic responses and allergic diseases of the respiratory tract. The influence of several allergic inflammatory mediators on the ciliary activity has been well studied. However, ciliary responsiveness to platelet-activating factor (PAF) is yet to be established conclu...

journal_title：International archives of allergy and immunology

authors： Ohashi Y,Ohno Y,Sugiura Y,Okamoto H,Tanaka A,Kakinoki Y,Sakamoto H,Hayashi M,Nakai Y

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:The hemagglutinin (HA) of influenza viruses is one of the major targets of the humoral response. The role of serum antibody to HA in the protection against infection has been demonstrated by long-standing observation. In previous studies, we suggested that an epitope vaccine might be a new strategy against t...

journal_title：International archives of allergy and immunology

authors： Lu Y,Ding J,Liu W,Chen YH

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:We have previously shown that the allergic sensitization to ovalbumin does not represent a superantigen-like immune response. In gene-targeted mice (ΔD-iD) with a single modified Diversity gene segment (D(H)) of the immunoglobulin heavy chain, enriched for charged amino acids, the asthma phenotype in a murin...

journal_title：International archives of allergy and immunology

authors： Kerzel S,Rogosch T,Wagner J,Preisser K,Yildirim AÖ,Fehrenbach H,Garn H,Maier RF,Schroeder HW Jr,Zemlin M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen G (HLA-G) is a nonclassical major histocompatibility complex class I gene. HLA-G stimulates Th2 cytokine secretion by peripheral blood mononuclear cells. The role of soluble HLA-G (sHLA-G) in bronchial asthma is incompletely understood and the plasma level of sHLA-G in asthmatic child...

journal_title：International archives of allergy and immunology

authors： Tahan F,Patiroglu T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Both oral and intravenous inhibitors of cyclic nucleotide phosphodiesterase (PDE) 3 and PDE4 have been shown to have bronchodilator and/or pulmonary antiallergic effects but their adverse effects limit the clinical use. The purpose of the present study was to assess the bronchoprotective effect of intrabronc...

journal_title：International archives of allergy and immunology

authors： Fujimura M,Tachibana H,Myou S,Kita T,Matsuda T

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker's asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called 'LTP syndrome'. METHODS:Eight adul...

journal_title：International archives of allergy and immunology

authors： Palacin A,Bartra J,Muñoz R,Diaz-Perales A,Valero A,Salcedo G

更新日期：2010-01-01 00:00:00

abstract：:Immunological suppression is one of the important aspects which govern the regulation of the immune response. Clonal deletion, clonal anergy and the activity of suppressor cells were proposed as mechanisms leading to this phenomenon. In this review we provide evidence for the existence of suppressor (Ts) cells and the...

journal_title：International archives of allergy and immunology

authors： Arnon R,Teitelbaum D

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Asthma is a common co-morbidity of allergic rhinitis (AR). The prevalence of these two allergic diseases has increased in China and has been shown to cluster in families independently. This study evaluated the association between maternal AR (presenting with or without asthma) and the allergic conditions in ...

journal_title：International archives of allergy and immunology

authors： Wang QP,Wu KM,Li ZQ,Xue F,Chen W,Ji H,Wang BL

更新日期：2012-01-01 00:00:00

abstract：:Oral immunotherapy (OIT) is a significant focus of treatment of food allergy. OIT appears to be effective in inducing desensitization, however, patients receiving OIT frequently developmild/moderate symptoms during the therapy. It has not been clearly established whether the clinical tolerance induced by OIT resembles...

journal_title：International archives of allergy and immunology

authors： Sato S,Yanagida N,Ogura K,Imai T,Utsunomiya T,Iikura K,Goto M,Asaumi T,Okada Y,Koike Y,Syukuya A,Ebisawa M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...

journal_title：International archives of allergy and immunology

authors： Jantunen J,Haahtela T,Salimäki J,Linna M,Mäkelä M,Pelkonen A,Kauppi P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:2-Arachidonoylglycerol (2-AG), an endogenous ligand for the cannabinoid receptors (CB1 and CB2), has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. Recently, we found that human eosinophilic leukemia EoL-1 cells and human peripheral blood eosinophils express the CB2 recept...

journal_title：International archives of allergy and immunology

authors： Kishimoto S,Oka S,Gokoh M,Sugiura T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Studies comparing skin prick test (SPT) devices have revealed varying results in performance and there is little known about their use on children. METHODS:We performed 2 complementary studies to test the sensitivity, reproducibility and acceptability of commercially available SPT devices (Stallerpoint, Ant...

journal_title：International archives of allergy and immunology

authors： Buyuktiryaki B,Sahiner UM,Karabulut E,Cavkaytar O,Tuncer A,Sekerel BE

更新日期：2013-01-01 00:00:00

abstract：:Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1). Cysteinyl leukotrienes are also suggested to be involved in remodeling with their potential to induce proliferation of a...

journal_title：International archives of allergy and immunology

authors： Kato Y,Fujisawa T,Nishimori H,Katsumata H,Atsuta J,Iguchi K,Kamiya H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJE...

journal_title：International archives of allergy and immunology

authors： Hagner S,Rask C,Brimnes J,Andersen PS,Raifer H,Renz H,Garn H

更新日期：2016-01-01 00:00:00