Role of the IgE-mediated system in eosinophil recruitment triggered by two consecutive cycles of sensitisation and challenge in rats.

abstract：:We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...

journal_title：International archives of allergy and immunology

authors： Profita M,Riccobono L,Bonanno A,Chanez P,Gagliardo R,Montalbano AM,Albano GD,Liotta G,Gjomarkaj M,La Grutta S

更新日期：2013-01-01 00:00:00

abstract：:We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...

journal_title：International archives of allergy and immunology

authors： Catini C,Miliani A,Macchi C

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...

journal_title：International archives of allergy and immunology

authors： Dissanayake E,Tani Y,Nagai K,Sahara M,Mitsuishi C,Togawa Y,Suzuki Y,Nakano T,Yamaide F,Ohno H,Shimojo N

更新日期：2019-01-01 00:00:00

abstract：:Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...

journal_title：International archives of allergy and immunology

authors： Aron AL,Gharavi AE,Shoenfeld Y

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. METHOD...

journal_title：International archives of allergy and immunology

authors： Leung TF,Kong AP,Chan IH,Choi KC,Ho CS,Chan MH,So WY,Lam CW,Wong GW,Chan JC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...

journal_title：International archives of allergy and immunology

authors： Wang J,Wu Y,Li J,Huang X,Zhu R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:It is assumed that the very late antigen-4 (VLA-4) plays a key role in selective migration and accumulation of eosinophils to the allergic inflammatory focus. The regulatory mechanism for VLA-4 expression is poorly understood, as is its relationship between other adhesion molecules. OBJECTIVE:The aim of the...

journal_title：International archives of allergy and immunology

authors： Kayaba H,Yamada Y,Cui CH,Saito N,Honda K,Kobayashi Y,Urayama O,Chihara J

更新日期：2001-01-01 00:00:00

abstract：:Volumetric air sampling was performed at Corpus Christi, Tex., September 1987 to August 1989. Grass aeropollen during all of 1988 accounted for 15.3% of total pollen captured during two major peaks, one in May and another during September and October. The remaining grass pollen, about one-quarter of the total, was fou...

journal_title：International archives of allergy and immunology

authors： Lewis WH,Dixit AB,Wedner HJ

更新日期：1992-01-01 00:00:00

abstract：:CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...

journal_title：International archives of allergy and immunology

authors： Lechner H,Amort M,Steger MM,Maczek C,Grubeck-Loebenstein B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The allergenic potential of chicken egg white ovomucoid (OVM) is thought to depend on its stability to heat treatment and digestion. Pepsin-digested fragments have been speculated to continue to exert an allergenic potential. OVM was digested in simulated gastric fluid (SGF) to examine the reactivity of the ...

journal_title：International archives of allergy and immunology

authors： Takagi K,Teshima R,Okunuki H,Itoh S,Kawasaki N,Kawanishi T,Hayakawa T,Kohno Y,Urisu A,Sawada J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS:We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmat...

journal_title：International archives of allergy and immunology

authors： Robinson DS,North J,Zeibecoglou K,Ying S,Meng Q,Rankin S,Hamid Q,Tavernier J,Kay AB

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Egg allergy is one of the most common food allergies in children. The standard therapy for egg allergy is strict avoidance. Yet, there is considerable clinical and scientific interest in primary or secondary prevention. A major drawback of oral tolerance (OT) induction protocols, however, is the possibility ...

journal_title：International archives of allergy and immunology

authors： Hacini-Rachinel F,Vissers YM,Doucet-Ladevéze R,Blanchard C,Demont A,Perrot M,Panchaud A,Prioult G,Mercenier A,Nutten S

更新日期：2014-01-01 00:00:00

abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

journal_title：International archives of allergy and immunology

authors： Thomas WR,Smith W,Hales BJ

更新日期：1998-01-01 00:00:00

abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

journal_title：International archives of allergy and immunology

authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Sensitivity to Chenopodiaceae is a frequent cause of allergic respiratory diseases in geographic areas where sensitization to Salsola kali and Chenopodium album has been reported. The objective of this study was to evaluate the pattern of sensitization to 3 Salsola species in patients residing on the Mediter...

journal_title：International archives of allergy and immunology

authors： Ferrer A,Larramendi CH,Huertas AJ,Pagán JA,Andreu C,García-Abujeta JL,López-Matas MA,Carnés J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Chronic urticaria is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, Th17 and Tc17 have been implicated in autoimmune diseases; however, their role in urticaria is not clear yet. METHODS:For the study we recruited 20 patients [10 of them had autoreactive chronic spontane...

journal_title：International archives of allergy and immunology

authors： Lopes A,Machado D,Pedreiro S,Henriques A,Silva I,Tavares B,Inácio MJ,Chieira C,Martinho A,Pais ML,Pereira C,Paiva A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

journal_title：International archives of allergy and immunology

authors： Mori A,Okudaira H,Kobayashi N,Akiyama K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...

journal_title：International archives of allergy and immunology

authors： Kamata Y,Miyanomae A,Nakayama E,Miyanomae T,Tajima T,Hoshi H

更新日期：2007-01-01 00:00:00

abstract：:It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when Eos were preincubated with cytochalasin B. ECP release induced by C3a or C5a was gr...

journal_title：International archives of allergy and immunology

authors： Takafuji S,Tadokoro K,Ito K,Dahinden CA

更新日期：1994-01-01 00:00:00

abstract：:Toll-like receptors have a critical role in innate immunity and host defence. However their role in allergic disease has not been studied in great detail. The presence of these receptors on mast cells opens up new possibilities concerning the role of Toll-like receptors in the pathogenesis of asthma and atopic dermati...

journal_title：International archives of allergy and immunology

authors： Marshall JS,McCurdy JD,Olynych T

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:To elucidate the usefulness of antigen-specific immunotherapy based on oral vaccination with an edible part of the plant, we examined the effect of transgenic (Tg) rice seeds expressing an immunodominant fragment of the group 1 antigen of Dermatophagoides pteronyssinus (Der p 1) on a murine model of asthma. ...

journal_title：International archives of allergy and immunology

authors： Suzuki K,Kaminuma O,Yang L,Motoi Y,Takai T,Ichikawa S,Okumura K,Ogawa H,Mori A,Takaiwa F,Hiroi T

更新日期：2009-01-01 00:00:00

abstract：:Mercuric chloride (HgCl(2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl(2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. In order to cha...

journal_title：International archives of allergy and immunology

authors： Loftenius A,Ekstrand J,Möller E

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) and eosinophilic granule proteins such as eosinophil-derived neurotoxin (EDN) are known to damage bronchial tissue and cause airway hyperresponsiveness (AHR) in asthma. Hepatocyte growth factor (HGF) regulates various biological activities and is known to be a multifunctional fa...

journal_title：International archives of allergy and immunology

authors： Ito W,Takeda M,Fujita M,Kamada Y,Kato H,Chiba T,Yamaguchi K,Ueki S,Kayaba H,Kanehiro A,Chihara J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that administration of probiotics in vitro can stimulate regulatory and Th1 immune responses. We studied both the in vitro immunological effects of probiotics and the ex vivo immunological effects after oral administration of probiotics in children with food allergy, a Th2-mediated d...

journal_title：International archives of allergy and immunology

authors： Flinterman AE,Knol EF,van Ieperen-van Dijk AG,Timmerman HM,Knulst AC,Bruijnzeel-Koomen CA,Pasmans SG,van Hoffen E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...

journal_title：International archives of allergy and immunology

authors： Jacquenet S,Morisset M,Battais F,Denery-Papini S,Croizier A,Baudouin E,Bihain B,Moneret-Vautrin DA

更新日期：2009-01-01 00:00:00

abstract：:A previous study described clinical and pathological manifestations observed in 49 chimeras produced by replacing a small fragment of the neural tube of a chicken embryo by a similar fragment from a Japanese quail embryo. Predominant antibodies in sera of these birds were directed against xenogeneic antigens which are...

journal_title：International archives of allergy and immunology

authors： Yang G,Albini B,Milgrom F

更新日期：1992-01-01 00:00:00

abstract：:HIV-1 RNA has become the standard for monitoring antiretroviral therapies. Dogma predicts, however, that a viral protein like p24 should be at least as good a marker of HIV disease activity, provided that it is measured with sufficient sensitivity and accuracy. Simple modifications including use of a more efficient vi...

journal_title：International archives of allergy and immunology

authors： Schüpbach J

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Modulating early immune response by application of bacteria and their by-products has been suggested as a preventive strategy against the development of allergic diseases. In light of this, the aim of the study was to test the effects of oral administration of bacterial lysates (BL) in a rat model of food al...

journal_title：International archives of allergy and immunology

authors： Ahrens B,Quarcoo D,Buhner S,Matricardi PM,Hamelmann E

更新日期：2011-01-01 00:00:00

abstract：:In the last 40 years, the pathogenesis of transmissible spongiform encephalopathies of humans and animals have been the subject of exciting discoveries and also of passionate controversies. Although the human forms of these diseases are rare, the recent epidemics of bovine spongiform encephalopathy has most dramatical...

journal_title：International archives of allergy and immunology

authors： Aguzzi A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific Ig...

journal_title：International archives of allergy and immunology

authors： Carsin AE,Zock JP,Jarvis D,Basagaña X,Heinrich J,Toren K,Janson C,Anto JM,Sunyer J

更新日期：2013-01-01 00:00:00