Abstract:
:In the last 40 years, the pathogenesis of transmissible spongiform encephalopathies of humans and animals have been the subject of exciting discoveries and also of passionate controversies. Although the human forms of these diseases are rare, the recent epidemics of bovine spongiform encephalopathy has most dramatically raised the issue of the transmissibility from affected animals to humans. This review summarizes some current hypotheses on the nature of the infectious agent causing these diseases, and on the pathogenetic pathways which produce histologically detectable damage to the central nervous system. The main focus is on the use of transgenic and knockout mice which, combined with organ transplantation and bone marrow reconstitution techniques, have provided powerful tools for dissecting the pathogenesis of these diseases.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Aguzzi Adoi
10.1159/000237273subject
Has Abstractpub_date
1996-06-01 00:00:00pages
99-106issue
2eissn
1018-2438issn
1423-0097journal_volume
110pub_type
历史文章,杂志文章,评审abstract:BACKGROUND:The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE:To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD:The...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000493328
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Environmental factors play an important role in asthma morbidity, although the contribution of individual pollutants or pollens in exacerbating asthma is not completely elucidated. Despite the evidence of importance of the hornbeam pollen in inducing allergic sensitization, its role in provoking asthma exace...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000322177
更新日期:2011-01-01 00:00:00
abstract::In murines, interleukins (IL) 3, 4, 9, and 10, nerve growth factor, and stem cell factor induce or promote growth and differentiation of mast cells (MC). Increased stimulation and synergy was observed when combinations of cytokines were used. In man, no growth factor for human MCs had been identified until recently, w...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236767
更新日期:1994-11-01 00:00:00
abstract::Hypersensitivity to latex proteins has been reported with increasing frequency in recent years. Elevated levels of latex specific IgE have been detected in the majority of these patients. Severe anaphylaxis and death resulting from latex exposure has also been reported. Nevertheless, the immune mechanism of latex alle...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236656
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Mast cells (MCs) are multifunctional effector cells of the immune system. These cells originate from pluripotent hemopoietic progenitors. In contrast to basophils and other leukocytes, MCs exhibit a remarkably long life span (years) in vivo. Although a role for stem cell factor (SCF) and SCF receptor (KIT) i...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000066773
更新日期:2002-11-01 00:00:00
abstract::The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080) on IgE-mediated reactions in vitro and in vivo were determined in rhesus monkeys. E6080 inhibited both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236406
更新日期:1993-01-01 00:00:00
abstract::Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000343018
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The European tick, Argas reflexus, is an urban pest parasitizing urban pigeons and may cause a wide range of allergic reactions. METHODS:Specific IgE to A. reflexus, SDS-PAGE and IgE immunoblotting, performed with tick extract, were carried out in the sera of 6 patients who reported allergic reactions after...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000082322
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. METHODS:Differences in clinical and laboratory parameters among AIU, PU and CIU groups were...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000103995
更新日期:2007-01-01 00:00:00
abstract::The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236161
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Disturbed cytokine production is thought to govern inflammation in asthma, which, in its turn, may lead to uncontrolled disease. The aim of this study was to assess the relationship between cytokine production from blood leucocytes and the level of asthma control. METHODS:We compared the production of inter...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000329858
更新日期:2012-01-01 00:00:00
abstract::To determine whether the costimulatory signal via CD28/B7 interaction is required for causing allergic inflammation, we examined the effect of administration of CTLA4-Ig, a fusion protein of the extracellular domain of CTLA4 and human IgG1-constant region, at the time of sensitization, on antigen-induced eosinophil in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053564
更新日期:1998-09-01 00:00:00
abstract::A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237161
更新日期:1995-11-01 00:00:00
abstract::A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000512561
更新日期:2021-01-27 00:00:00
abstract::Platelet-activating factor (PAF)-induced augmentation of spontaneous differentiation into eosinophil-lineage cells from hematopoietic precursor cells was found among human umbilical cord blood mononuclear cells (CBMCs). This ability of PAF to augment eosinophil production was significantly (p < 0.01) inhibited by the ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236586
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Epinephrine autoinjector (EAI) is prescribed to prevent a fatal outcome in the case of a repeated anaphylactic reactions. We wanted to determine how adult patients who received their first prescription as part of an urgent treatment of an anaphylactic reaction or at their family physician were instructed on ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000513421
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:The allergenic potential of chicken egg white ovomucoid (OVM) is thought to depend on its stability to heat treatment and digestion. Pepsin-digested fragments have been speculated to continue to exert an allergenic potential. OVM was digested in simulated gastric fluid (SGF) to examine the reactivity of the ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000082581
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Mast cell tryptase has recently been reported to be involved in atherosclerotic plaque destabilization. However, the results of these reports are conflicting. METHODS:The aim of this study was to characterize the role of tryptase as a prognostic marker of patient cardiovascular complexity in acute coronary ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000360164
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000512944
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Previous studies suggest that administration of probiotics in vitro can stimulate regulatory and Th1 immune responses. We studied both the in vitro immunological effects of probiotics and the ex vivo immunological effects after oral administration of probiotics in children with food allergy, a Th2-mediated d...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000099467
更新日期:2007-01-01 00:00:00
abstract::We investigated the effects of KW-4679, an antiallergic drug, on the development of bronchial hyperresponsiveness, airway inflammation and early and late asthmatic responses following aerosol antigen challenge in guinea pigs actively sensitized by the inhalation of aerosolized ovalbumin. Pretreatment with KW-4679 (10 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237312
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:It is important to understand that allergic rhinitis, whether seasonal or perennial, may be difficult to distinguish clinically from the nonallergic forms of rhinitis. OBJECTIVE:This study aimed to investigate the presence of local allergic rhinitis (LAR) in children who have allergic rhinitis symptoms in t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447635
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Adoptive transfer of helper T (Th) cells conferred a late asthmatic response upon antigen challenge. A possible production of a contractile activity for bronchial smooth muscle (BSM) by activated Th cells was examined. METHOD:Murine Th clones were stimulated with immobilized anti-CD3 antibody in the presenc...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000337743
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000078768
更新日期:2004-07-01 00:00:00
abstract::Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000101398
更新日期:2007-01-01 00:00:00
abstract:AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024359
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000260088
更新日期:2010-01-01 00:00:00
abstract::Antibodies to specific autoantigens are serological hallmarks of systemic autoimmune diseases. These autoantibodies are thought to represent a consequence of immune dysregulation in these conditions, and, in part, have been shown to be involved in their pathologic consequences. However, the mechanisms that lead to the...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000024422
更新日期:2000-09-01 00:00:00
abstract:INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...
journal_title:International archives of allergy and immunology
pub_type: 新闻
doi:10.1159/000511148
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000499875
更新日期:2019-01-01 00:00:00