Abstract:
:Rupture of intracranial saccular aneurysms continues to result in significant morbidity and mortality. Although it has long been thought that biomechanical factors play key roles in the genesis, growth, and rupture of these lesions, few analysis have employed realistic descriptions of the geometries and material properties. This paper presents parametric finite element studies for subclasses of elliptical and spherical lesions which complement those recently reported by Kyriacou and Humphrey. In particular, we show again that lesion shape, not size, is a primary determinant of aneurysmal wall stress. Moreover, material anisotropy and geometry can exhibit competing or synergistic effects on the stress fields - this suggests that these interactions may be important in the formulation of theories on lesion growth. Finally, we show that Laplace's equation (for spherical membranes) yields reasonable approximations for wall stress only for a very limited class of lesions. There is a need, therefore, for detailed analysis and thus more precise data on lesion geometry, material properties, and loading conditions.
journal_name
Comput Methods Biomech Biomed Enginauthors
Shah AD,Harris JL,Kyriacou SK,Humphrey JDdoi
10.1080/01495739708936698keywords:
subject
Has Abstractpub_date
1998-01-01 00:00:00pages
109-121issue
2eissn
1025-5842issn
1476-8259pii
I291L970969journal_volume
1pub_type
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journal_title:Computer methods in biomechanics and biomedical engineering
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