Abstract:
:Cell-cell and cell-matrix adhesions are fundamental to numerous physiological processes, including angiogenesis, tumourigenesis, metastatic spreading and wound healing. We use cellular potts model to computationally predict the organisation of cells within a 3D matrix. The energy potentials regulating cell-cell (JCC) and cell-matrix (JMC) adhesive interactions are systematically varied to represent different, biologically relevant adhesive conditions. Chemotactically induced cell migration is also addressed. Starting from a cluster of cells, variations in relative cell adhesion alone lead to different cellular patterns such as spreading of metastatic tumours and angiogenesis. The combination of low cell-cell adhesion (high JCC) and high heterotypic adhesion (low JMC) favours the fragmentation of the original cluster into multiple, smaller cell clusters (metastasis). Conversely, cellular systems exhibiting high-homotypic affinity (low JCC) preserve their original configuration, avoiding fragmentation (organogenesis). For intermediate values of JCC and JMC (i.e. JCC/JMC ∼ 1), tubular and corrugated structures form. Fully developed vascular trees are assembled only in systems in which contact-inhibited chemotaxis is activated upon cell contact. Also, the rate of secretion, diffusion and sequestration of chemotactic factors, cell deformability and motility do not significantly affect these trends. Further developments of this computational model will predict the efficacy of therapeutic interventions to modulate the diseased microenvironment by directly altering cell cohesion.
journal_name
Comput Methods Biomech Biomed Enginauthors
Singh J,Hussain F,Decuzzi Pdoi
10.1080/10255842.2013.792917subject
Has Abstractpub_date
2015-01-01 00:00:00pages
282-92issue
3eissn
1025-5842issn
1476-8259journal_volume
18pub_type
杂志文章abstract::Microarchitectural finite element models have become a key tool in the analysis of trabecular bone. Robust, accurate, and validated constitutive models would enhance confidence in predictive applications of these models and in their usefulness as accurate assays of tissue properties. Human trabecular bone specimens fr...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2015.1041022
更新日期:2016-01-01 00:00:00
abstract::Design optimization for cementless hip prosthesis signifies one of the key topics of research to improve its performances. However, majority of the studies have not considered the presence of uncertainties while it has been shown that a deterministic optimization leads to an unreliable design. In this paper, a multi-o...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2020.1768247
更新日期:2020-09-01 00:00:00
abstract::The normalcy index (NI) has been implemented by several studies as a simple index for quantitatively analyzing diffident gait abnormalities, such as children with cerebral palsy and idiopathic toe-walkers. However, whether the NI can be used in anterior cruciate ligament (ACL) deficiency with different types of menisc...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2020.1789119
更新日期:2020-11-01 00:00:00
abstract::Polyurethane (PU) foam is a material often used in biomechanical experiments and demands for the definition of crushable foam plasticity (CFP) in numerical simulations of the primary stability and deformation of implants, to describe the crushing behaviour appropriately. Material data of PU foams with five different d...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1524884
更新日期:2019-01-01 00:00:00
abstract::We present a one-dimensional (1D) fluid dynamic model that can predict blood flow and blood pressure during exercise using data collected at rest. To facilitate accurate prediction of blood flow, we developed an impedance boundary condition using morphologically derived structured trees. Our model was validated by com...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840601068638
更新日期:2007-02-01 00:00:00
abstract::Biomechanical imaging techniques have been developed for soft tissue characterisation and detection of breast tumours. Harmonic motion imaging (HMI) uses a focused ultrasound technology to generate a harmonic radiation force in a localised region inside a soft tissue. The resulting dynamic response is used to map the ...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2012.736500
更新日期:2014-01-01 00:00:00
abstract::Much attention has been devoted to how playground swing amplitudes are built up by swinger techniques, i.e. body actions. However, very little attention has been given to the requirements that such swinger techniques place on the swinger himself. The purpose of this study was to find out whether different swinger tech...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2011.572280
更新日期:2012-01-01 00:00:00
abstract::The multispiked connecting scaffold (MSC-scaffold) prototype is an essential innovation in the fixation of components of resurfacing arthroplasty (RA) endoprostheses, providing their entirely non-cemented and bone-tissue-preserving fixation in peri-articular bone. An FE study is proposed to evaluate the influence of g...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1480759
更新日期:2018-07-01 00:00:00
abstract::New trends of numerical models of human joints require more and more computation of both large amplitude joint motions and fine bone stress distribution. Together, these problems are difficult to solve and very CPU time consuming. The goal of this study is to develop a new method to diminish the calculation time for t...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/1025584021000016843
更新日期:2002-12-01 00:00:00
abstract::In this work, we present a technique to semi-automatically quantify the epicardial fat in non-contrasted computed tomography (CT) images. The epicardial fat is very close to the pericardial fat, being separated only by the pericardium that appears in the image as a very thin line, which is hard to detect. Therefore, a...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.499871
更新日期:2011-10-01 00:00:00
abstract::Several opensource or commercially available software platforms are widely used to develop dynamic simulations of movement. While computational approaches are conceptually similar across platforms, technical differences in implementation may influence output. We present a new upper limb dynamic model as a tool to eval...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2014.916698
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to evaluate the stress distributions and deformations of the temporomandibular joint (TMJ) during different periods before and after sagittal split ramus osteotomy (SSRO). A three-dimensional finite element model of the mandible and TMJ was established, based on the preoperative CT of a patie...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2018.1504034
更新日期:2018-08-01 00:00:00
abstract::The flow effect on the concentration of platelet active substances in the vicinity of a mural microthrombus is investigated numerically. A three-dimensional model is employed in which the mural microthrombus is modelled as a semisphere attached to a plane surface. The description of the blood flow uses the three-dimen...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/01495739808936708
更新日期:1998-01-01 00:00:00
abstract::It is still unclear how a vertebral fracture should be stabilised and strengthened without endangering the remaining intact bone of the augmented vertebra or the adjacent vertebrae. Numerical modelling may provide insight. To date, however, few finite element (FE) spine models have been developed which are both multi-...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2010.522183
更新日期:2012-01-01 00:00:00
abstract::Traumatic brain injury (TBI), induced by impact of an object with the head, is a major health problem worldwide. Rats are a well-established animal analogue for study of TBI and the weight-drop impact-acceleration (WDIA) method is a well-established model in rats for creating diffuse TBI, the most common form of TBI s...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1280733
更新日期:2017-05-01 00:00:00
abstract::When designing any rehabilitation, sportswear or exoskeleton device the mechanical behaviour of the body segment must be known, specifically the skin, because an excessive tissue strain may lead to ulceration and bedsores. To date, it is not known if the kinematic variability between subjects have an effect on the ski...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2019.1655549
更新日期:2019-11-01 00:00:00
abstract::In almost all finite element (FE) studies in dentistry, virtual forces are applied directly to dentures. The purpose of this study was to develop a FE model with non-linear contact simulation using an antagonist as force transmitter and to compare this with a similar model that uses direct force transmission. Furtherm...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1338691
更新日期:2017-08-01 00:00:00
abstract::Pelvic disorders can be associated with changes in the biomechanical properties in the muscle, ligaments and/or connective tissue form fascia and ligaments. In this sense, the study of their mechanical behavior is important to understand the structure and function of these biological soft tissues. The aim of this stud...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2017.1304542
更新日期:2017-06-01 00:00:00
abstract::Being seated for long periods, while part of many leisure or occupational activities, can lead to discomfort, pain and sometimes health issues. The impact of prolonged sitting on the body has been widely studied in the literature, with a large number of human-body finite element models developed to simulate sitting an...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章,评审
doi:10.1080/10255842.2018.1466117
更新日期:2018-03-01 00:00:00
abstract::In order to improve the reliability of children's models, the aim of this study was to determine the subject-specific masses and 3D locations of the centres of mass (CoM) of body segments using biplanar X-rays. Previous methods, validated on upper leg segments, were applied to the whole body. Six children and six adul...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255841003717608
更新日期:2010-12-01 00:00:00
abstract::There are no blood vessels in cartilage to transport nutrients and growth factors to chondrocytes dispersed throughout the cartilage matrix. Insulin-like growth factor-I (IGF-I) is a large molecule with an important role in cartilage growth and metabolism, however, it first must reach the chondrocytes to exert its eff...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840701309163
更新日期:2007-08-01 00:00:00
abstract::Woodpeckers can withstand a fierce impact during pecking without any brain injury. Although directly involved in the whole pecking, the role of the jaw apparatus played in the impact-resistant process of woodpeckers is still not fully clear. We employed finite element analysis, impact tests in vivo, and post-traumatic...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2020.1838489
更新日期:2021-01-13 00:00:00
abstract::The combination of computational methods with 3D printing allows for the control of scaffolds microstructure. Lately, triply periodic minimal surfaces (TPMS) have been used to design porosity-controlled scaffolds for bone tissue engineering (TE). The goal of this work was to assess the mechanical properties of TPMS Gy...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2019.1569638
更新日期:2019-05-01 00:00:00
abstract::This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and ac...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2013.763938
更新日期:2014-11-01 00:00:00
abstract::The phenotype expression in X-linked adrenoleukodystrophy is one of the most intriguing issues of the disease, because there is no general correlation between the type of ABCD1 gene mutation and the clinical phenotype. In this study, we use the cross-impact analysis to build a descriptively quantitative relationship b...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840903279974
更新日期:2010-06-01 00:00:00
abstract::Electrocardiogram (ECG) signals are difficult to interpret, and clinicians must undertake a long training process to learn to diagnose diabetes from subtle abnormalities in these signals. To facilitate these diagnoses, we have developed a technique based on the heart rate variability signal obtained from ECG signals. ...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2011.616945
更新日期:2013-01-01 00:00:00
abstract::Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury (DTI). Deformation plays an important role in the aetiology of DTI. Therefore, it is essential to minimise internal muscle deformations in subjects at...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2011.627682
更新日期:2013-01-01 00:00:00
abstract::The presence of a spiral arterial blood flow pattern in humans has been widely accepted. It is believed that this spiral component of the blood flow alters arterial haemodynamics in both positive and negative ways. The purpose of this study was to determine the effect of spiral flow on haemodynamic changes in aorta-re...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2015.1082552
更新日期:2016-01-01 00:00:00
abstract::A computational model of an oscillatory laminar flow of an incompressible Newtonian fluid has been carried out in the proximal part of human tracheobronchial trees, either normal or with a strongly stenosed right main bronchus. After acquisition with a multislice spiral CT, the thoracic images are processed to reconst...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255840500289624
更新日期:2005-08-01 00:00:00
abstract::Rupture prediction of abdominal aortic aneurysms (AAAs) remains a clinical challenge. Finite element analysis (FEA) may allow for improved identification for intervention timing, but the method needs further substantiation. In this study, experimental photoelastic method and finite element techniques were compared usi...
journal_title:Computer methods in biomechanics and biomedical engineering
pub_type: 杂志文章
doi:10.1080/10255842.2011.574618
更新日期:2012-01-01 00:00:00