Role of differential adhesion in cell cluster evolution: from vasculogenesis to cancer metastasis.

Abstract:

:Cell-cell and cell-matrix adhesions are fundamental to numerous physiological processes, including angiogenesis, tumourigenesis, metastatic spreading and wound healing. We use cellular potts model to computationally predict the organisation of cells within a 3D matrix. The energy potentials regulating cell-cell (JCC) and cell-matrix (JMC) adhesive interactions are systematically varied to represent different, biologically relevant adhesive conditions. Chemotactically induced cell migration is also addressed. Starting from a cluster of cells, variations in relative cell adhesion alone lead to different cellular patterns such as spreading of metastatic tumours and angiogenesis. The combination of low cell-cell adhesion (high JCC) and high heterotypic adhesion (low JMC) favours the fragmentation of the original cluster into multiple, smaller cell clusters (metastasis). Conversely, cellular systems exhibiting high-homotypic affinity (low JCC) preserve their original configuration, avoiding fragmentation (organogenesis). For intermediate values of JCC and JMC (i.e. JCC/JMC ∼ 1), tubular and corrugated structures form. Fully developed vascular trees are assembled only in systems in which contact-inhibited chemotaxis is activated upon cell contact. Also, the rate of secretion, diffusion and sequestration of chemotactic factors, cell deformability and motility do not significantly affect these trends. Further developments of this computational model will predict the efficacy of therapeutic interventions to modulate the diseased microenvironment by directly altering cell cohesion.

authors

Singh J,Hussain F,Decuzzi P

doi

10.1080/10255842.2013.792917

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

282-92

issue

3

eissn

1025-5842

issn

1476-8259

journal_volume

18

pub_type

杂志文章
  • The sensitivity of nonlinear computational models of trabecular bone to tissue level constitutive model.

    abstract::Microarchitectural finite element models have become a key tool in the analysis of trabecular bone. Robust, accurate, and validated constitutive models would enhance confidence in predictive applications of these models and in their usefulness as accurate assays of tissue properties. Human trabecular bone specimens fr...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2015.1041022

    authors: Baumann AP,Shi X,Roeder RK,Niebur GL

    更新日期:2016-01-01 00:00:00

  • Multi-objective reliability based design optimization using Kriging surrogate model for cementless hip prosthesis.

    abstract::Design optimization for cementless hip prosthesis signifies one of the key topics of research to improve its performances. However, majority of the studies have not considered the presence of uncertainties while it has been shown that a deterministic optimization leads to an unreliable design. In this paper, a multi-o...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1768247

    authors: Dammak K,El Hami A

    更新日期:2020-09-01 00:00:00

  • Use of the normalcy index for the assessment of abnormal gait in the anterior cruciate ligament deficiency combined with meniscus injury.

    abstract::The normalcy index (NI) has been implemented by several studies as a simple index for quantitatively analyzing diffident gait abnormalities, such as children with cerebral palsy and idiopathic toe-walkers. However, whether the NI can be used in anterior cruciate ligament (ACL) deficiency with different types of menisc...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1789119

    authors: Liu X,Huang H,Ren S,Rong Q,Ao Y

    更新日期:2020-11-01 00:00:00

  • Calibration of crushable foam plasticity models for synthetic bone material for use in finite element analysis of acetabular cup deformation and primary stability.

    abstract::Polyurethane (PU) foam is a material often used in biomechanical experiments and demands for the definition of crushable foam plasticity (CFP) in numerical simulations of the primary stability and deformation of implants, to describe the crushing behaviour appropriately. Material data of PU foams with five different d...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2018.1524884

    authors: Schulze C,Vogel D,Sander M,Bader R

    更新日期:2019-01-01 00:00:00

  • Fractal network model for simulating abdominal and lower extremity blood flow during resting and exercise conditions.

    abstract::We present a one-dimensional (1D) fluid dynamic model that can predict blood flow and blood pressure during exercise using data collected at rest. To facilitate accurate prediction of blood flow, we developed an impedance boundary condition using morphologically derived structured trees. Our model was validated by com...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840601068638

    authors: Steele BN,Olufsen MS,Taylor CA

    更新日期:2007-02-01 00:00:00

  • Modelling of global boundary effects on harmonic motion imaging of soft tissues.

    abstract::Biomechanical imaging techniques have been developed for soft tissue characterisation and detection of breast tumours. Harmonic motion imaging (HMI) uses a focused ultrasound technology to generate a harmonic radiation force in a localised region inside a soft tissue. The resulting dynamic response is used to map the ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2012.736500

    authors: Zhao X,Pelegri AA

    更新日期:2014-01-01 00:00:00

  • An assessment of swinger techniques for the playground swing oscillatory motion.

    abstract::Much attention has been devoted to how playground swing amplitudes are built up by swinger techniques, i.e. body actions. However, very little attention has been given to the requirements that such swinger techniques place on the swinger himself. The purpose of this study was to find out whether different swinger tech...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.572280

    authors: Linge SO

    更新日期:2012-01-01 00:00:00

  • Numerical studies of the influence of various geometrical features of a multispiked connecting scaffold prototype on mechanical stresses in peri-implant bone.

    abstract::The multispiked connecting scaffold (MSC-scaffold) prototype is an essential innovation in the fixation of components of resurfacing arthroplasty (RA) endoprostheses, providing their entirely non-cemented and bone-tissue-preserving fixation in peri-articular bone. An FE study is proposed to evaluate the influence of g...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2018.1480759

    authors: Uklejewski R,Winiecki M,Patalas A,Rogala P

    更新日期:2018-07-01 00:00:00

  • Virtual power based algorithm for decoupling large motions from infinitesimal strains: application to shoulder joint biomechanics.

    abstract::New trends of numerical models of human joints require more and more computation of both large amplitude joint motions and fine bone stress distribution. Together, these problems are difficult to solve and very CPU time consuming. The goal of this study is to develop a new method to diminish the calculation time for t...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/1025584021000016843

    authors: Büchler P,Rakotomanana L,Farron A

    更新日期:2002-12-01 00:00:00

  • Towards automatic quantification of the epicardial fat in non-contrasted CT images.

    abstract::In this work, we present a technique to semi-automatically quantify the epicardial fat in non-contrasted computed tomography (CT) images. The epicardial fat is very close to the pericardial fat, being separated only by the pericardium that appears in the image as a very thin line, which is hard to detect. Therefore, a...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2010.499871

    authors: Barbosa JG,Figueiredo B,Bettencourt N,Tavares JM

    更新日期:2011-10-01 00:00:00

  • Benchmarking of dynamic simulation predictions in two software platforms using an upper limb musculoskeletal model.

    abstract::Several opensource or commercially available software platforms are widely used to develop dynamic simulations of movement. While computational approaches are conceptually similar across platforms, technical differences in implementation may influence output. We present a new upper limb dynamic model as a tool to eval...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2014.916698

    authors: Saul KR,Hu X,Goehler CM,Vidt ME,Daly M,Velisar A,Murray WM

    更新日期:2015-01-01 00:00:00

  • The Biomechanical Effects of Sagittal Split Ramus Osteotomy on Temporomandibular Joint.

    abstract::The aim of this study was to evaluate the stress distributions and deformations of the temporomandibular joint (TMJ) during different periods before and after sagittal split ramus osteotomy (SSRO). A three-dimensional finite element model of the mandible and TMJ was established, based on the preoperative CT of a patie...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2018.1504034

    authors: Liu Z,Shu J,Zhang Y,Fan Y

    更新日期:2018-08-01 00:00:00

  • The Influence of Flow on the Concentration of Platelet Active Substances in the Vicinity of Mural Microthrombi.

    abstract::The flow effect on the concentration of platelet active substances in the vicinity of a mural microthrombus is investigated numerically. A three-dimensional model is employed in which the mural microthrombus is modelled as a semisphere attached to a plane surface. The description of the blood flow uses the three-dimen...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/01495739808936708

    authors: Karner G,Perktold K

    更新日期:1998-01-01 00:00:00

  • Mechanical variables affecting balloon kyphoplasty outcome--a finite element study.

    abstract::It is still unclear how a vertebral fracture should be stabilised and strengthened without endangering the remaining intact bone of the augmented vertebra or the adjacent vertebrae. Numerical modelling may provide insight. To date, however, few finite element (FE) spine models have been developed which are both multi-...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2010.522183

    authors: Dabirrahmani D,Becker S,Hogg M,Appleyard R,Baroud G,Gillies M

    更新日期:2012-01-01 00:00:00

  • A multi-body dynamics study on a weight-drop test of rat brain injury.

    abstract::Traumatic brain injury (TBI), induced by impact of an object with the head, is a major health problem worldwide. Rats are a well-established animal analogue for study of TBI and the weight-drop impact-acceleration (WDIA) method is a well-established model in rats for creating diffuse TBI, the most common form of TBI s...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2017.1280733

    authors: Yan W,Sossou G,Rajan R

    更新日期:2017-05-01 00:00:00

  • In vivo measurement of surface skin strain during human gait to improve the design of rehabilitation devices.

    abstract::When designing any rehabilitation, sportswear or exoskeleton device the mechanical behaviour of the body segment must be known, specifically the skin, because an excessive tissue strain may lead to ulceration and bedsores. To date, it is not known if the kinematic variability between subjects have an effect on the ski...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2019.1655549

    authors: Barrios-Muriel J,Romero Sánchez F,Alonso Sánchez FJ,Rodríguez Salgado D

    更新日期:2019-11-01 00:00:00

  • The effect of direct and indirect force transmission on peri-implant bone stress - a contact finite element analysis.

    abstract::In almost all finite element (FE) studies in dentistry, virtual forces are applied directly to dentures. The purpose of this study was to develop a FE model with non-linear contact simulation using an antagonist as force transmitter and to compare this with a similar model that uses direct force transmission. Furtherm...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2017.1338691

    authors: Rand A,Stiesch M,Eisenburger M,Greuling A

    更新日期:2017-08-01 00:00:00

  • Biomechanical properties of the pelvic floor muscles of continent and incontinent women using an inverse finite element analysis.

    abstract::Pelvic disorders can be associated with changes in the biomechanical properties in the muscle, ligaments and/or connective tissue form fascia and ligaments. In this sense, the study of their mechanical behavior is important to understand the structure and function of these biological soft tissues. The aim of this stud...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2017.1304542

    authors: Silva MET,Brandão S,Parente MPL,Mascarenhas T,Natal Jorge RM

    更新日期:2017-06-01 00:00:00

  • Finite element models of the thigh-buttock complex for assessing static sitting discomfort and pressure sore risk: a literature review.

    abstract::Being seated for long periods, while part of many leisure or occupational activities, can lead to discomfort, pain and sometimes health issues. The impact of prolonged sitting on the body has been widely studied in the literature, with a large number of human-body finite element models developed to simulate sitting an...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1080/10255842.2018.1466117

    authors: Savonnet L,Wang X,Duprey S

    更新日期:2018-03-01 00:00:00

  • Subject-specific body segment parameters' estimation using biplanar X-rays: a feasibility study.

    abstract::In order to improve the reliability of children's models, the aim of this study was to determine the subject-specific masses and 3D locations of the centres of mass (CoM) of body segments using biplanar X-rays. Previous methods, validated on upper leg segments, were applied to the whole body. Six children and six adul...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255841003717608

    authors: Sandoz B,Laporte S,Skalli W,Mitton D

    更新日期:2010-12-01 00:00:00

  • Solute transport in cartilage undergoing cyclic deformation.

    abstract::There are no blood vessels in cartilage to transport nutrients and growth factors to chondrocytes dispersed throughout the cartilage matrix. Insulin-like growth factor-I (IGF-I) is a large molecule with an important role in cartilage growth and metabolism, however, it first must reach the chondrocytes to exert its eff...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840701309163

    authors: Gardiner B,Smith D,Pivonka P,Grodzinsky A,Frank E,Zhang L

    更新日期:2007-08-01 00:00:00

  • The cushioning function of woodpecker's jaw apparatus during the pecking process.

    abstract::Woodpeckers can withstand a fierce impact during pecking without any brain injury. Although directly involved in the whole pecking, the role of the jaw apparatus played in the impact-resistant process of woodpeckers is still not fully clear. We employed finite element analysis, impact tests in vivo, and post-traumatic...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2020.1838489

    authors: Xu P,Ni Y,Lu S,Liu S,Zhou X,Fan Y

    更新日期:2021-01-13 00:00:00

  • Numerical and experimental evaluation of TPMS Gyroid scaffolds for bone tissue engineering.

    abstract::The combination of computational methods with 3D printing allows for the control of scaffolds microstructure. Lately, triply periodic minimal surfaces (TPMS) have been used to design porosity-controlled scaffolds for bone tissue engineering (TE). The goal of this work was to assess the mechanical properties of TPMS Gy...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2019.1569638

    authors: Castro APG,Ruben RB,Gonçalves SB,Pinheiro J,Guedes JM,Fernandes PR

    更新日期:2019-05-01 00:00:00

  • A two population model of prion transport through a tunnelling nanotube.

    abstract::This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and ac...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2013.763938

    authors: Kuznetsov IA,Kuznetsov AV

    更新日期:2014-11-01 00:00:00

  • Linking mutated primary structure of adrenoleukodystrophy protein with X-linked adrenoleukodystrophy.

    abstract::The phenotype expression in X-linked adrenoleukodystrophy is one of the most intriguing issues of the disease, because there is no general correlation between the type of ABCD1 gene mutation and the clinical phenotype. In this study, we use the cross-impact analysis to build a descriptively quantitative relationship b...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840903279974

    authors: Yan S,Wu G

    更新日期:2010-06-01 00:00:00

  • An integrated diabetic index using heart rate variability signal features for diagnosis of diabetes.

    abstract::Electrocardiogram (ECG) signals are difficult to interpret, and clinicians must undertake a long training process to learn to diagnose diabetes from subtle abnormalities in these signals. To facilitate these diagnoses, we have developed a technique based on the heart rate variability signal obtained from ECG signals. ...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.616945

    authors: Acharya UR,Faust O,Sree SV,Ghista DN,Dua S,Joseph P,Ahamed VI,Janarthanan N,Tamura T

    更新日期:2013-01-01 00:00:00

  • How does muscle stiffness affect the internal deformations within the soft tissue layers of the buttocks under constant loading?

    abstract::Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury (DTI). Deformation plays an important role in the aetiology of DTI. Therefore, it is essential to minimise internal muscle deformations in subjects at...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.627682

    authors: Loerakker S,Solis LR,Bader DL,Baaijens FP,Mushahwar VK,Oomens CW

    更新日期:2013-01-01 00:00:00

  • Spiral blood flow in aorta-renal bifurcation models.

    abstract::The presence of a spiral arterial blood flow pattern in humans has been widely accepted. It is believed that this spiral component of the blood flow alters arterial haemodynamics in both positive and negative ways. The purpose of this study was to determine the effect of spiral flow on haemodynamic changes in aorta-re...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2015.1082552

    authors: Javadzadegan A,Simmons A,Barber T

    更新日期:2016-01-01 00:00:00

  • An image-based computational model of oscillatory flow in the proximal part of tracheobronchial trees.

    abstract::A computational model of an oscillatory laminar flow of an incompressible Newtonian fluid has been carried out in the proximal part of human tracheobronchial trees, either normal or with a strongly stenosed right main bronchus. After acquisition with a multislice spiral CT, the thoracic images are processed to reconst...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255840500289624

    authors: Fetita C,Mancini S,Perchet D,Prêteux F,Thiriet M,Vial L

    更新日期:2005-08-01 00:00:00

  • Finite element and photoelastic modelling of an abdominal aortic aneurysm: a comparative study.

    abstract::Rupture prediction of abdominal aortic aneurysms (AAAs) remains a clinical challenge. Finite element analysis (FEA) may allow for improved identification for intervention timing, but the method needs further substantiation. In this study, experimental photoelastic method and finite element techniques were compared usi...

    journal_title:Computer methods in biomechanics and biomedical engineering

    pub_type: 杂志文章

    doi:10.1080/10255842.2011.574618

    authors: Callanan A,Morris LG,McGloughlin TM

    更新日期:2012-01-01 00:00:00