A two population model of prion transport through a tunnelling nanotube.

Abstract:

:This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and active actin-dependent transport inside endocytic vesicles that are propelled by myosin Va molecular motors. Analytical solutions describing prion concentrations and fluxes are obtained. Numerical results are compared with those predicted by a single prion population model that relies on a single reaction-diffusion equation and accounts for the two modes of prion transport in an effective way.

authors

Kuznetsov IA,Kuznetsov AV

doi

10.1080/10255842.2013.763938

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1705-15

issue

15

eissn

1025-5842

issn

1476-8259

journal_volume

17

pub_type

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