Abstract:
:In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly replicated chromosomal elements; (ii) regulation of the activity of the DnaA initiator protein; and (iii) sequestration of the dnaA gene promoter. This review represents the first attempt to consider together older and more recent data on such inactivation mechanisms in order to analyze their contributions to the overall tight replication control observed in vivo. All cells have developed mechanisms for origin inactivation, but those of other bacteria and eukaryotic cells are clearly distinct from those of E. coli. Possible differences and similarities are discussed.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Boye E,Løbner-Olesen A,Skarstad Kdoi
10.1093/embo-reports/kvd116keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
479-83issue
6eissn
1469-221Xissn
1469-3178journal_volume
1pub_type
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