A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

abstract：:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, p...

journal_title：EMBO reports

authors： Sriram A,Bohlen J,Teleman AA

更新日期：2018-10-01 00:00:00

abstract：:The mitochondrial matrix protease CLPP plays a central role in the activation of the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans Far less is known about mammalian UPR(mt) signaling, although similar roles were assumed for central players, including CLPP To better understand the mammalia...

journal_title：EMBO reports

authors： Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A

更新日期：2016-07-01 00:00:00

abstract：:Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi-protein complex is activated by supernumerary centrosomes to induce p53 and restrict proliferation of polyplo...

journal_title：EMBO reports

authors： Sladky VC,Knapp K,Szabo TG,Braun VZ,Bongiovanni L,van den Bos H,Spierings DC,Westendorp B,Curinha A,Stojakovic T,Scharnagl H,Timelthaler G,Tsuchia K,Pinter M,Semmler G,Foijer F,de Bruin A,Reiberger T,Rohr-Udilova N,

更新日期：2020-11-23 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have significant side effects. A...

journal_title：EMBO reports

authors： Ploss A,Rice CM

更新日期：2009-11-01 00:00:00

abstract：:Intercellular communication orchestrates effective immune responses against disease-causing agents. Extracellular vesicles (EVs) are potent mediators of cell-cell communication. EVs carry bioactive molecules, including microRNAs, which modulate gene expression and function in the recipient cell. Here, we show that for...

journal_title：EMBO reports

authors： Fernández-Messina L,Rodríguez-Galán A,de Yébenes VG,Gutiérrez-Vázquez C,Tenreiro S,Seabra MC,Ramiro AR,Sánchez-Madrid F

更新日期：2020-04-03 00:00:00

abstract：:STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250 partners of STK38 and find that STK38 modulates its partnership depending on the cellular context by increa...

journal_title：EMBO reports

authors： Martin AP,Jacquemyn M,Lipecka J,Chhuon C,Aushev VN,Meunier B,Singh MK,Carpi N,Piel M,Codogno P,Hergovich A,Parrini MC,Zalcman G,Guerrera IC,Daelemans D,Camonis JH

更新日期：2019-11-05 00:00:00

abstract：:Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...

journal_title：EMBO reports

authors： Yan WW,Liang YL,Zhang QX,Wang D,Lei MZ,Qu J,He XH,Lei QY,Wang YP

更新日期：2018-12-01 00:00:00

abstract：:Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expression of distinct estroge...

journal_title：EMBO reports

authors： Moggs JG,Orphanides G

更新日期：2001-09-01 00:00:00

abstract：:The role of long noncoding RNAs (lncRNAs) in viral infection is poorly studied. We have identified hepatitis C virus (HCV)-Stimulated lncRNAs (CSRs) by transcriptome analysis. Interestingly, two of these CSRs (PVT1 and UCA1) play relevant roles in tumorigenesis, providing a novel link between HCV infection and develop...

journal_title：EMBO reports

authors： Carnero E,Barriocanal M,Prior C,Pablo Unfried J,Segura V,Guruceaga E,Enguita M,Smerdou C,Gastaminza P,Fortes P

更新日期：2016-07-01 00:00:00

abstract：:Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation and for assembling fully functional kinetochores. Here, we used vertebrate cells conditionally ...

journal_title：EMBO reports

authors： Vagnarelli P,Morrison C,Dodson H,Sonoda E,Takeda S,Earnshaw WC

更新日期：2004-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unk...

journal_title：EMBO reports

authors： Groppa E,Brkic S,Uccelli A,Wirth G,Korpisalo-Pirinen P,Filippova M,Dasen B,Sacchi V,Muraro MG,Trani M,Reginato S,Gianni-Barrera R,Ylä-Herttuala S,Banfi A

更新日期：2018-05-01 00:00:00

abstract：:The gastrointestinal tract undergoes homeostatic self-renewal to replace aged and damaged epithelial cells. This process, sustained by intestinal stem cells (ISCs), can operate accurately for many years but gradually declines with age. Although stem cell aging has been intensively explored, the mechanisms remain poorl...

journal_title：EMBO reports

authors： Zhang P,Edgar BA

更新日期：2020-08-05 00:00:00

abstract：:Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condi...

journal_title：EMBO reports

authors： Clayton EL,Isaacs AM

更新日期：2020-10-05 00:00:00

abstract：:Small non-coding miRNA appear to be vital in brain development and function by organising complex patterns of gene expression. These molecules are important for the regulation of synaptically localised mRNAs that encode proteins involved in neurotransmission and behaviour. In this issue of EMBO Reports, Lackinger et a...

journal_title：EMBO reports

authors： Cairns MJ

更新日期：2019-02-01 00:00:00

abstract：:Central to chemotaxis is the molecular mechanism by which cells exhibit directed movement in shallow gradients of a chemoattractant. We used Dictyostelium mutants to investigate the minimal requirements for chemotaxis, and identified a basal signalling module providing activation of Ras at the leading edge, which is s...

journal_title：EMBO reports

authors： Kortholt A,Kataria R,Keizer-Gunnink I,Van Egmond WN,Khanna A,Van Haastert PJ

更新日期：2011-12-01 00:00:00

abstract：:Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...

journal_title：EMBO reports

authors： Fritsch L,Martinez LA,Sekhri R,Naguibneva I,Gérard M,Vandromme M,Schaeffer L,Harel-Bellan A

更新日期：2004-02-01 00:00:00

abstract：:The tubby loci provide a unique opportunity to study adult-onset obesity. Mutation in either mammalian tubby or its homologue in Caenorhabditis elegans, tub-1, results in increased fat storage. Previously, we have shown that TUB-1 interacts with a new Rab GTPase-activating protein, RBG-3, for the regulation of fat sto...

journal_title：EMBO reports

authors： Mukhopadhyay A,Pan X,Lambright DG,Tissenbaum HA

更新日期：2007-10-01 00:00:00

abstract：:The tumor suppressor Smad4, a key mediator of the TGF-β/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen-activated protein kinase (MAPK) plays a pivotal role in regulating its transcriptional activity and stability. In contrast, r...

journal_title：EMBO reports

authors： Park DS,Yoon GH,Kim EY,Lee T,Kim K,Lee PC,Chang EJ,Choi SC

更新日期：2020-05-06 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by f...

journal_title：EMBO reports

authors： Muñoz IM,Rouse J

更新日期：2009-03-01 00:00:00

abstract：:Foxp3(+) regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)-like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg suppressor function ...

journal_title：EMBO reports

authors： Kitz A,de Marcken M,Gautron AS,Mitrovic M,Hafler DA,Dominguez-Villar M

更新日期：2016-08-01 00:00:00

abstract：:The active and inactive X chromosomes have distinct epigenetic marks in somatic nuclei, which undergo reprogramming after transplantation into oocytes. We show that, despite the disappearance of Xist RNA coating in 30 min, the epigenetic memory of the inactive X persists with the precocious appearance of histone H3 tr...

journal_title：EMBO reports

authors： Bao S,Miyoshi N,Okamoto I,Jenuwein T,Heard E,Azim Surani M

更新日期：2005-08-01 00:00:00

abstract：:IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebra...

journal_title：EMBO reports

authors： Hedman AC,Smith JM,Sacks DB

更新日期：2015-04-01 00:00:00

abstract：:Mu bacteriophage inserts its DNA into the genome of host bacteria and is used as a model for DNA transposition events in other systems. The eukaryotic Ku protein has key roles in DNA repair and in certain transposition events. Here we show that the Gam protein of phage Mu is conserved in bacteria, has sequence homolog...

journal_title：EMBO reports

authors： d'Adda di Fagagna F,Weller GR,Doherty AJ,Jackson SP

更新日期：2003-01-01 00:00:00

abstract：:Reading the academic literature is an essential part of a scientist's job. David Smith argues that reading fiction can be even more important for creativity and productivity than papers and reviews. ...

journal_title：EMBO reports

authors： Smith DR

更新日期：2021-01-04 00:00:00

abstract：:The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously reported that expression of KV10.1 i...

journal_title：EMBO reports

authors： Sánchez A,Urrego D,Pardo LA

更新日期：2016-05-01 00:00:00

abstract：:Endo180, also known as the urokinase plasminogen activator receptor (uPAR)-associated protein (uPARAP), is one of the four members of the mannose receptor family, and is implicated in extracellular-matrix remodelling through its interactions with collagens, sugars and uPAR. The extracellular portion of Endo180 contain...

journal_title：EMBO reports

authors： Rivera-Calzada A,Robertson D,MacFadyen JR,Boskovic J,Isacke CM,Llorca O

更新日期：2003-08-01 00:00:00

abstract：:Mammalian artificial chromosomes (MACs) provide a new tool for the improvement of our knowledge of chromosome structure and function. Moreover, they constitute an alternative and potentially powerful tool for gene delivery both in cultured cells and for the production of transgenic animals. In the present work we desc...

journal_title：EMBO reports

authors： Auriche C,Donini P,Ascenzioni F

更新日期：2001-02-01 00:00:00

abstract：:A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and disc...

journal_title：EMBO reports

authors： Chicas A,Macino G

更新日期：2001-11-01 00:00:00

abstract：:Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

journal_title：EMBO reports

authors： Fernandez-Capetillo O

更新日期：2010-01-01 00:00:00