A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

abstract：:Yeast species have undergone extensive genome reorganization in their evolutionary history, including variations in chromosome number and large chromosomal rearrangements, such as translocations. To determine directly the contribution of chromosomal translocations to the whole organism's fitness, we devised a strategy...

journal_title：EMBO reports

authors： Colson I,Delneri D,Oliver SG

更新日期：2004-04-01 00:00:00

abstract：:Small non-coding miRNA appear to be vital in brain development and function by organising complex patterns of gene expression. These molecules are important for the regulation of synaptically localised mRNAs that encode proteins involved in neurotransmission and behaviour. In this issue of EMBO Reports, Lackinger et a...

journal_title：EMBO reports

authors： Cairns MJ

更新日期：2019-02-01 00:00:00

abstract：:Transcription is a complex process that integrates the state of the cell and its environment to generate adequate responses for cell fitness and survival. Recent microscopy experiments have been able to monitor transcription from single genes in individual cells. These observations have revealed two striking features:...

journal_title：EMBO reports

authors： Lionnet T,Singer RH

更新日期：2012-04-02 00:00:00

abstract：:The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated a significant number of clones in the public databases, as a result of the use of the transposon in bacterial cloning st...

journal_title：EMBO reports

authors： Hill F,Gemünd C,Benes V,Ansorge W,Gibson TJ

更新日期：2000-07-01 00:00:00

abstract：:ARGONAUTE 1 (AGO1) slices endogenous messenger RNAs (mRNAs) during both microRNA (miRNA)- and short interfering RNA (siRNA)-guided post-transcriptional silencing. We have previously reported that AGO1 homeostasis is maintained through the repressive action of miR168 on AGO1 mRNA and the stabilizing effect of AGO1 prot...

journal_title：EMBO reports

authors： Mallory AC,Vaucheret H

更新日期：2009-05-01 00:00:00

abstract：:Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for th...

journal_title：EMBO reports

authors： Zezula J,Casaccia-Bonnefil P,Ezhevsky SA,Osterhout DJ,Levine JM,Dowdy SF,Chao MV,Koff A

更新日期：2001-01-01 00:00:00

abstract：:X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...

journal_title：EMBO reports

authors： Ng K,Pullirsch D,Leeb M,Wutz A

更新日期：2007-01-01 00:00:00

abstract：:Endo180, also known as the urokinase plasminogen activator receptor (uPAR)-associated protein (uPARAP), is one of the four members of the mannose receptor family, and is implicated in extracellular-matrix remodelling through its interactions with collagens, sugars and uPAR. The extracellular portion of Endo180 contain...

journal_title：EMBO reports

authors： Rivera-Calzada A,Robertson D,MacFadyen JR,Boskovic J,Isacke CM,Llorca O

更新日期：2003-08-01 00:00:00

abstract：:Autophagosome formation is promoted by the PI3 kinase complex and negatively regulated by myotubularin phosphatases, indicating that regulation of local phosphatidylinositol 3-phosphate (PtdIns3P) levels is important for this early phase of autophagy. Here, we show that the Caenorhabditis elegans myotubularin phosphat...

journal_title：EMBO reports

authors： Wu Y,Cheng S,Zhao H,Zou W,Yoshina S,Mitani S,Zhang H,Wang X

更新日期：2014-09-01 00:00:00

abstract：:Epidermal growth factor (EGF) activates the EGF receptor (EGFR) and stimulates its internalization and trafficking to lysosomes for degradation. However, a percentage of EGFR undergoes ligand-independent endocytosis and is rapidly recycled back to the plasma membrane. Importantly, alterations in EGFR recycling are a c...

journal_title：EMBO reports

authors： Ioannou MS,Kulasekaran G,Fotouhi M,Morein JJ,Han C,Tse S,Nossova N,Han T,Mannard E,McPherson PS

更新日期：2017-12-01 00:00:00

abstract：:The Polycomb group (PcG) of proteins conveys epigenetic inheritance of repressed transcriptional states. In Drosophila, the Polycomb repressive complex 1 (PRC1) maintains the silent state by inhibiting the transcription machinery and chromatin remodelling at core promoters. Using immunoprecipitation of in vivo formald...

journal_title：EMBO reports

authors： Breiling A,O'Neill LP,D'Eliseo D,Turner BM,Orlando V

更新日期：2004-10-01 00:00:00

abstract：:Potentially pathogenic bacteria, such as Escherichia coli and Vibrio cholerae, become non-culturable during stasis. The analysis of such cells has been hampered by difficulties in studying bacterial population heterogeneity. Using in situ detection of protein oxidation in single E. coli cells, and using a density-grad...

journal_title：EMBO reports

authors： Desnues B,Cuny C,Grégori G,Dukan S,Aguilaniu H,Nyström T

更新日期：2003-04-01 00:00:00

abstract：:Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold...

journal_title：EMBO reports

authors： Uhlmann F

更新日期：2009-10-01 00:00:00

abstract：:The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that ...

journal_title：EMBO reports

authors： Gras S,Chaumont V,Fernandez B,Carpentier P,Charrier-Savournin F,Schmitt S,Pineau C,Flament D,Hecker A,Forterre P,Armengaud J,Housset D

更新日期：2007-06-01 00:00:00

abstract：:COVID-19 highlighted the importance of science and scientists to produce vaccines, cures and diagnostics. But scientists need to be careful not to overpromise on what they can deliver. ...

journal_title：EMBO reports

authors： Gannon F

更新日期：2020-11-05 00:00:00

abstract：:Reading the academic literature is an essential part of a scientist's job. David Smith argues that reading fiction can be even more important for creativity and productivity than papers and reviews. ...

journal_title：EMBO reports

authors： Smith DR

更新日期：2021-01-04 00:00:00

abstract：:Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we report a role for MEK-dr...

journal_title：EMBO reports

authors： Byun JK,Park M,Yun JW,Lee J,Kim JS,Cho SJ,Lee YM,Lee IK,Choi YK,Park KG

更新日期：2019-06-01 00:00:00

abstract：:Caspase malfunction in stem cells often precedes the appearance and progression of multiple types of cancer, including human colorectal cancer. However, the caspase-dependent regulation of intestinal stem cell properties remains poorly understood. Here, we demonstrate that Dronc, the Drosophila ortholog of caspase-9/2...

journal_title：EMBO reports

authors： Arthurton L,Nahotko DA,Alonso J,Wendler F,Baena-Lopez LA

更新日期：2020-11-01 00:00:00

abstract：:Around 100 researchers gathered at the eighteenth EMBO Conference on 'The Molecular and Developmental Biology of Drosophila', which took place in Crete in June 2012. Whether deconstructing or integrating at the genetic, cellular or organ level, the talks highlighted the synergy of combining methods, approaches and dis...

journal_title：EMBO reports

authors： Miguel-Aliaga I,Oliver B,Teleman AA

更新日期：2012-11-06 00:00:00

abstract：:gamma-Secretase-dependent regulated intramembrane proteolysis of amyloid precursor protein (APP) releases the APP intracellular domain (AICD). The question of whether this domain, like the Notch intracellular domain, is involved in nuclear signalling is highly controversial. Although some reports suggest that AICD reg...

journal_title：EMBO reports

authors： Hébert SS,Serneels L,Tolia A,Craessaerts K,Derks C,Filippov MA,Müller U,De Strooper B

更新日期：2006-07-01 00:00:00

abstract：:Proteins of the Imp4/Brix superfamily are involved in ribosomal RNA processing, an essential function in all cells. We report the first structure of an Imp4/Brix superfamily protein, the Mil (for Methanothermobacter thermautotrophicus Imp4-like) protein (gene product Mth680), from the archaeon M. thermautotrophicus. T...

journal_title：EMBO reports

authors： Ng CL,Waterman D,Koonin EV,Antson AA,Ortiz-Lombardía M

更新日期：2005-02-01 00:00:00

abstract：:Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of re...

journal_title：EMBO reports

authors： Lefebvre B,Ozato K,Lefebvre P

更新日期：2002-04-01 00:00:00

abstract：:Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize th...

journal_title：EMBO reports

authors： Soares MP,Weiss G

更新日期：2015-11-01 00:00:00

abstract：:Research into the extreme feats of endurance that humans and some animals achieve has uncovered a range of metabolic and physiological adaptations along with their evolutionary origins. ...

journal_title：EMBO reports

authors： Hunter P

更新日期：2019-11-05 00:00:00

abstract：:The discovery that adult somatic cells can be reprogrammed into pluripotent cells by expressing a combination of factors associated with pluripotency holds immense promise for a wide range of biotechnological and therapeutic applications. However, some hurdles-such as improving the low reprogramming efficiencies and e...

journal_title：EMBO reports

authors： Banito A,Gil J

更新日期：2010-05-01 00:00:00

abstract：:The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric enzyme complexes. Assembly factors assist in these biogenesis processes by providing co-factors or stabilizing transient assembly s...

journal_title：EMBO reports

authors： Wang C,Richter-Dennerlein R,Pacheu-Grau D,Liu F,Zhu Y,Dennerlein S,Rehling P

更新日期：2020-01-07 00:00:00

abstract：:Several mechanisms have been proposed for the synthesis of substrate-linked ubiquitin chains. HECT ligases directly catalyse protein ubiquitination and have been found to non-covalently interact with ubiquitin. We report crystal structures of the Nedd4 HECT domain, alone and in complex with ubiquitin, which show a new...

journal_title：EMBO reports

authors： Maspero E,Mari S,Valentini E,Musacchio A,Fish A,Pasqualato S,Polo S

更新日期：2011-04-01 00:00:00

abstract：:The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated. Specifically, the precise contribution o...

journal_title：EMBO reports

authors： Bonora M,Morganti C,Morciano G,Pedriali G,Lebiedzinska-Arciszewska M,Aquila G,Giorgi C,Rizzo P,Campo G,Ferrari R,Kroemer G,Wieckowski MR,Galluzzi L,Pinton P

更新日期：2017-07-01 00:00:00

abstract：:Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological a...

journal_title：EMBO reports

authors： Lopez-Mejia IC,de Toledo M,Chavey C,Lapasset L,Cavelier P,Lopez-Herrera C,Chebli K,Fort P,Beranger G,Fajas L,Amri EZ,Casas F,Tazi J

更新日期：2014-05-01 00:00:00

abstract：:Given that ligand binding is essential for the rapid internalization of epidermal growth factor receptor (EGFR), the events induced by ligand binding probably contribute to the regulation of EGFR internalization. These events include receptor dimerization, activation of intrinsic tyrosine kinase activity and autophosp...

journal_title：EMBO reports

authors： Wang Q,Villeneuve G,Wang Z

更新日期：2005-10-01 00:00:00