Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.

abstract：:Although iron is required for cell proliferation, iron-dependent programmed cell death serves as a critical barrier to tumor growth and metastasis. Emerging evidence suggests that iron-mediated lipid oxidation also facilitates immune eradication of cancer. However, the regulatory mechanisms of iron metabolism in cance...

journal_title：EMBO reports

authors： Song J,Liu T,Yin Y,Zhao W,Lin Z,Yin Y,Lu D,You F

更新日期：2021-01-04 00:00:00

abstract：:In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA--U3, U14 and snR30--whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the pre-ribosome association to all 75 yeast snoRNAs in strains de...

journal_title：EMBO reports

authors： Bohnsack MT,Kos M,Tollervey D

更新日期：2008-12-01 00:00:00

abstract：:The highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show ...

journal_title：EMBO reports

authors： Picollo A,Liantonio A,Didonna MP,Elia L,Camerino DC,Pusch M

更新日期：2004-06-01 00:00:00

abstract：:Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-p...

journal_title：EMBO reports

authors： Hwang G,Kim S,Cho JY,Paik I,Kim JI,Oh E

更新日期：2019-10-04 00:00:00

abstract：:The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In a...

journal_title：EMBO reports

authors： Colombo R,Boggio R,Seiser C,Draetta GF,Chiocca S

更新日期：2002-11-01 00:00:00

abstract：:The high-resolution spatial induction of ultraviolet (UV) photoproducts in mammalian cellular DNA is a goal of many scientists who study UV damage and repair. Here we describe how UV photoproducts can be induced in cellular DNA within nanometre dimensions by near-diffraction-limited 750 nm infrared laser radiation. Th...

journal_title：EMBO reports

authors： Meldrum RA,Botchway SW,Wharton CW,Hirst GJ

更新日期：2003-12-01 00:00:00

abstract：:Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we report a role for MEK-dr...

journal_title：EMBO reports

authors： Byun JK,Park M,Yun JW,Lee J,Kim JS,Cho SJ,Lee YM,Lee IK,Choi YK,Park KG

更新日期：2019-06-01 00:00:00

abstract：:There is a great interest in determining the impact of p53 on ageing and, for this, it is important to discriminate among the known causes of ageing. Telomere loss is a well-established source of age-associated damage, which by itself can recapitulate ageing in mouse models. Here, we have used a genetic approach to in...

journal_title：EMBO reports

authors： García-Cao I,García-Cao M,Tomás-Loba A,Martín-Caballero J,Flores JM,Klatt P,Blasco MA,Serrano M

更新日期：2006-05-01 00:00:00

abstract：:A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential ...

journal_title：EMBO reports

authors： Cokol M,Nair R,Rost B

更新日期：2000-11-01 00:00:00

abstract：:Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newl...

journal_title：EMBO reports

authors： Camara JE,Breier AM,Brendler T,Austin S,Cozzarelli NR,Crooke E

更新日期：2005-08-01 00:00:00

abstract：:LeuT serves as the model protein for understanding the relationships between structure, mechanism and pharmacology in neurotransmitter sodium symporters (NSSs). At the present time, however, there is a vigorous debate over whether there is a single high-affinity substrate site (S1) located at the original, crystallogr...

journal_title：EMBO reports

authors： Wang H,Gouaux E

更新日期：2012-09-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P4 ) promotes CCA in the uterine epithelium and previous studies indicated that P4 activates RB by reducing the phosphorylated, inactive form of RB. Here, we show that embryo implantation is impaired...

journal_title：EMBO reports

authors： Akaeda S,Hirota Y,Fukui Y,Aikawa S,Shimizu-Hirota R,Kaku T,Gebril M,Hirata T,Hiraoka T,Matsuo M,Haraguchi H,Saito-Kanatani M,Takeda N,Fujii T,Osuga Y

更新日期：2021-01-05 00:00:00

abstract：:Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

journal_title：EMBO reports

authors： Harris RE,Ashe HL

更新日期：2011-06-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB zinc-finger proteins (KZNFs), but little is known about the regulation of ERVs in adult tissues...

journal_title：EMBO reports

authors： Tie CH,Fernandes L,Conde L,Robbez-Masson L,Sumner RP,Peacock T,Rodriguez-Plata MT,Mickute G,Gifford R,Towers GJ,Herrero J,Rowe HM

更新日期：2018-10-01 00:00:00

abstract：:Sulphatases undergo a unique post-translational modification that converts a highly conserved cysteine located within their active site into formylglycine. This modification is necessary for the catalytic activities of the sulphatases, and it is generated by the protein product of sulphatase-modifying factor 1 (SUMF1)...

journal_title：EMBO reports

authors： Zito E,Fraldi A,Pepe S,Annunziata I,Kobinger G,Di Natale P,Ballabio A,Cosma MP

更新日期：2005-07-01 00:00:00

abstract：:Pair-rule genes in Drosophila integrate the positional information provided by the transcription factor gradients of gap genes and set the framework for the expression of the segment polarity genes. Pair-rule genes are also expressed during the segmentation of the short germ-band embryo of the flour beetle Tribolium, ...

journal_title：EMBO reports

authors： Eckert C,Aranda M,Wolff C,Tautz D

更新日期：2004-06-01 00:00:00

abstract：:The angiotensin II type 1 (AT(1)) receptor is a G protein-coupled receptor that has a crucial role in the development of load-induced cardiac hypertrophy. Here, we show that cell stretch leads to activation of the AT(1) receptor, which undergoes an anticlockwise rotation and a shift of transmembrane (TM) 7 into the li...

journal_title：EMBO reports

authors： Yasuda N,Miura S,Akazawa H,Tanaka T,Qin Y,Kiya Y,Imaizumi S,Fujino M,Ito K,Zou Y,Fukuhara S,Kunimoto S,Fukuzaki K,Sato T,Ge J,Mochizuki N,Nakaya H,Saku K,Komuro I

更新日期：2008-02-01 00:00:00

abstract：:Immune signaling networks must be tunable to alleviate fitness costs associated with immunity and, at the same time, robust against pathogen interferences. How these properties mechanistically emerge in plant immune signaling networks is poorly understood. Here, we discovered a molecular mechanism by which the model p...

journal_title：EMBO reports

authors： Mine A,Nobori T,Salazar-Rondon MC,Winkelmüller TM,Anver S,Becker D,Tsuda K

更新日期：2017-03-01 00:00:00

abstract：:The denitrosylase S-nitrosoglutathione reductase (GSNOR) has been suggested to sustain mitochondrial removal by autophagy (mitophagy), functionally linking S-nitrosylation to cell senescence and aging. In this study, we provide evidence that GSNOR is induced at the translational level in response to hydrogen peroxide ...

journal_title：EMBO reports

authors： Cirotti C,Rizza S,Giglio P,Poerio N,Allega MF,Claps G,Pecorari C,Lee JH,Benassi B,Barilà D,Robert C,Stamler JS,Cecconi F,Fraziano M,Paull TT,Filomeni G

更新日期：2020-11-27 00:00:00

abstract：:The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...

journal_title：EMBO reports

authors： Ahuja M,Muallem S

更新日期：2014-03-01 00:00:00

abstract：:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...

journal_title：EMBO reports

authors： Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao M

更新日期：2013-02-01 00:00:00

abstract：:The components and pathways that regulate and execute developmental cell death programmes in plants remain largely unknown. We have found that the PROMOTION OF CELL SURVIVAL 1 (PCS1) gene in Arabidopsis, which encodes an aspartic protease, has an important role in determining the fate of cells in embryonic development...

journal_title：EMBO reports

authors： Ge X,Dietrich C,Matsuno M,Li G,Berg H,Xia Y

更新日期：2005-03-01 00:00:00

abstract：:Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that N...

journal_title：EMBO reports

authors： Sundqvist A,Liu G,Mirsaliotis A,Xirodimas DP

更新日期：2009-10-01 00:00:00

abstract：:The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a...

journal_title：EMBO reports

authors： Nitta T,Muro R,Shimizu Y,Nitta S,Oda H,Ohte Y,Goto M,Yanobu-Takanashi R,Narita T,Takayanagi H,Yasuda H,Okamura T,Murata S,Suzuki H

更新日期：2015-05-01 00:00:00

abstract：:The systematic recording and management of experimental data in academic life science research remains an open problem. EPFL engaged in a program of ELN/LIMS deployment 6 years ago, encountering a host of fundamental questions at the institutional level and in each single laboratory. Here, based on our experience we a...

journal_title：EMBO reports

authors： Argento N

更新日期：2020-03-04 00:00:00

abstract：:Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for th...

journal_title：EMBO reports

authors： Zezula J,Casaccia-Bonnefil P,Ezhevsky SA,Osterhout DJ,Levine JM,Dowdy SF,Chao MV,Koff A

更新日期：2001-01-01 00:00:00

abstract：:Mitochondrial respiration generates an electrochemical proton gradient across the mitochondrial inner membrane called protonmotive force (PMF) to drive diverse functions and synthesize ATP. Current techniques to manipulate the PMF are limited to its dissipation; yet, there is no precise and reversible method to increa...

journal_title：EMBO reports

authors： Berry BJ,Trewin AJ,Milliken AS,Baldzizhar A,Amitrano AM,Lim Y,Kim M,Wojtovich AP

更新日期：2020-04-03 00:00:00

abstract：:Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication init...

journal_title：EMBO reports

authors： Datta A,Ghatak D,Das S,Banerjee T,Paul A,Butti R,Gorain M,Ghuwalewala S,Roychowdhury A,Alam SK,Das P,Chatterjee R,Dasgupta M,Panda CK,Kundu GC,Roychoudhury S

更新日期：2017-11-01 00:00:00

abstract：:Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer ...

journal_title：EMBO reports

authors： Xu X,Zhou H,Boyer TG

更新日期：2011-03-01 00:00:00