Abstract:
:IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Hedman AC,Smith JM,Sacks DBdoi
10.15252/embr.201439834subject
Has Abstractpub_date
2015-04-01 00:00:00pages
427-46issue
4eissn
1469-221Xissn
1469-3178pii
embr.201439834journal_volume
16pub_type
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