Abstract:
:The gastrointestinal tract undergoes homeostatic self-renewal to replace aged and damaged epithelial cells. This process, sustained by intestinal stem cells (ISCs), can operate accurately for many years but gradually declines with age. Although stem cell aging has been intensively explored, the mechanisms remain poorly understood. In this issue of EMBO Reports, Du et al report that alpha-lipoic acid (ALA) sustains an active endocytosis-autophagy network that effectively reverses age-dependent ISC hyperplasia in Drosophila (Du et al, 2020). This work suggests a new strategy for treating aging-associated gastrointestinal diseases.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Zhang P,Edgar BAdoi
10.15252/embr.202051175subject
Has Abstractpub_date
2020-08-05 00:00:00pages
e51175issue
8eissn
1469-221Xissn
1469-3178journal_volume
21pub_type
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