Abstract:
:Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and participates in maternal mtDNA inheritance. Under stress, mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy. In addition, many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy. Here, we review the emerging roles of ubiquitin at mitochondria.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Escobar-Henriques M,Langer Tdoi
10.1002/embr.201338225subject
Has Abstractpub_date
2014-03-01 00:00:00pages
231-43issue
3eissn
1469-221Xissn
1469-3178pii
embr.201338225journal_volume
15pub_type
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