A matter of choice: the establishment of sister chromatid cohesion.

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, eac...

journal_title：EMBO reports

authors： Klosowiak JL,Focia PJ,Chakravarthy S,Landahl EC,Freymann DM,Rice SE

更新日期：2013-11-01 00:00:00

abstract：:Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigen...

journal_title：EMBO reports

authors： Augert A,Payré C,de Launoit Y,Gil J,Lambeau G,Bernard D

更新日期：2009-03-01 00:00:00

abstract：:IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebra...

journal_title：EMBO reports

authors： Hedman AC,Smith JM,Sacks DB

更新日期：2015-04-01 00:00:00

abstract：:COVID-19 highlighted the importance of science and scientists to produce vaccines, cures and diagnostics. But scientists need to be careful not to overpromise on what they can deliver. ...

journal_title：EMBO reports

authors： Gannon F

更新日期：2020-11-05 00:00:00

abstract：:The angiotensin II type 1 (AT(1)) receptor is a G protein-coupled receptor that has a crucial role in the development of load-induced cardiac hypertrophy. Here, we show that cell stretch leads to activation of the AT(1) receptor, which undergoes an anticlockwise rotation and a shift of transmembrane (TM) 7 into the li...

journal_title：EMBO reports

authors： Yasuda N,Miura S,Akazawa H,Tanaka T,Qin Y,Kiya Y,Imaizumi S,Fujino M,Ito K,Zou Y,Fukuhara S,Kunimoto S,Fukuzaki K,Sato T,Ge J,Mochizuki N,Nakaya H,Saku K,Komuro I

更新日期：2008-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unk...

journal_title：EMBO reports

authors： Groppa E,Brkic S,Uccelli A,Wirth G,Korpisalo-Pirinen P,Filippova M,Dasen B,Sacchi V,Muraro MG,Trani M,Reginato S,Gianni-Barrera R,Ylä-Herttuala S,Banfi A

更新日期：2018-05-01 00:00:00

abstract：:The histone H3 N-terminal protein domain (N-tail) is regulated by multiple posttranslational modifications, including methylation, acetylation, phosphorylation, and by proteolytic cleavage. However, the mechanism underlying H3 N-tail proteolytic cleavage is largely elusive. Here, we report that JMJD5, a Jumonji C (Jmj...

journal_title：EMBO reports

authors： Shen J,Xiang X,Chen L,Wang H,Wu L,Sun Y,Ma L,Gu X,Liu H,Wang L,Yu YN,Shao J,Huang C,Chin YE

更新日期：2017-12-01 00:00:00

abstract：:Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and pa...

journal_title：EMBO reports

authors： Escobar-Henriques M,Langer T

更新日期：2014-03-01 00:00:00

abstract：:Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that N...

journal_title：EMBO reports

authors： Sundqvist A,Liu G,Mirsaliotis A,Xirodimas DP

更新日期：2009-10-01 00:00:00

abstract：:Apoptotic cell volume decrease (AVD) and exposure of phosphatidylserine (PtdSer) at the cell surface are early events in apoptosis. However, the ion channels responsible for AVD, and their relationship to PtdSer translocation and cell death are poorly understood. Real-time analysis of calcium-induced apoptosis in lymp...

journal_title：EMBO reports

authors： Elliott JI,Higgins CF

更新日期：2003-02-01 00:00:00

abstract：:Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts...

journal_title：EMBO reports

authors： Nava P,Capaldo CT,Koch S,Kolegraff K,Rankin CR,Farkas AE,Feasel ME,Li L,Addis C,Parkos CA,Nusrat A

更新日期：2011-04-01 00:00:00

abstract：:Labmates are colleagues, friends, comforters…and competitors. ...

journal_title：EMBO reports

authors： Morriswood B,Hoeller O

更新日期：2019-07-01 00:00:00

abstract：:Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol 3,5-bisphosphate. ...

journal_title：EMBO reports

authors： Jefferies HB,Cooke FT,Jat P,Boucheron C,Koizumi T,Hayakawa M,Kaizawa H,Ohishi T,Workman P,Waterfield MD,Parker PJ

更新日期：2008-02-01 00:00:00

abstract：:The high-resolution spatial induction of ultraviolet (UV) photoproducts in mammalian cellular DNA is a goal of many scientists who study UV damage and repair. Here we describe how UV photoproducts can be induced in cellular DNA within nanometre dimensions by near-diffraction-limited 750 nm infrared laser radiation. Th...

journal_title：EMBO reports

authors： Meldrum RA,Botchway SW,Wharton CW,Hirst GJ

更新日期：2003-12-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:Ligands for nuclear receptors facilitate the exchange of co-repressors for coactivators, leading to chromatin modifications that favour the activation of gene transcription. Here, we show that the repressed state of an endogenous retinoic acid-regulated gene is quickly re-established after ligand removal. As expected,...

journal_title：EMBO reports

authors： Hartman HB,Yu J,Alenghat T,Ishizuka T,Lazar MA

更新日期：2005-05-01 00:00:00

abstract：:Despite its limited resources, Portugal has gained a prominent position in research on malaria. Several historical and personal factors have contributed to this achievement. ...

journal_title：EMBO reports

authors： Prudêncio M

更新日期：2021-01-10 00:00:00

abstract：:Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in...

journal_title：EMBO reports

authors： Holland AJ,Cleveland DW

更新日期：2012-06-01 00:00:00

abstract：:In Drosophila melanogaster males, X-chromosome monosomy is compensated by chromosome-wide transcription activation. We found that complete dosage compensation during embryogenesis takes surprisingly long and is incomplete even after 10 h of development. Although the activating dosage compensation complex (DCC) associa...

journal_title：EMBO reports

authors： Prayitno K,Schauer T,Regnard C,Becker PB

更新日期：2019-08-01 00:00:00

abstract：:There is a great interest in determining the impact of p53 on ageing and, for this, it is important to discriminate among the known causes of ageing. Telomere loss is a well-established source of age-associated damage, which by itself can recapitulate ageing in mouse models. Here, we have used a genetic approach to in...

journal_title：EMBO reports

authors： García-Cao I,García-Cao M,Tomás-Loba A,Martín-Caballero J,Flores JM,Klatt P,Blasco MA,Serrano M

更新日期：2006-05-01 00:00:00

abstract：:The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...

journal_title：EMBO reports

authors： Mak DO,Pearson JE,Loong KP,Datta S,Fernández-Mongil M,Foskett JK

更新日期：2007-11-01 00:00:00

abstract：:Howy Jacobs reminisces about his many editorials and asks whether they have ever been read by anyone. ...

journal_title：EMBO reports

authors： Jacobs H

更新日期：2020-07-03 00:00:00

abstract：:Endocytosis and subsequent lysosomal degradation of activated signalling receptors can attenuate signalling. Endocytosis may also promote signalling by targeting receptors to specific compartments. A key step regulating the degradation of receptors is their ubiquitination. Hrs/Vps27p, an endosome-associated, ubiquitin...

journal_title：EMBO reports

authors： Jékely G,Rørth P

更新日期：2003-12-01 00:00:00

abstract：:Dynactin has been proposed to link the microtubule-associated motor cytoplasmic dynein with membranous cargo; however, the mechanism by which dynactin-membrane interaction is regulated is unknown. Here we show that dynein and dynactin exist in discrete cytosolic and membrane-bound states in the filamentous fungus Neur...

journal_title：EMBO reports

authors： Kumar S,Zhou Y,Plamann M

更新日期：2001-10-01 00:00:00

abstract：:The Wnt signaling pathway can be grouped into two classes, the β-catenin-dependent and β-catenin-independent pathways. Wnt5a signaling through a β-catenin-independent pathway promotes microtubule (MT) remodeling during cell-substrate adhesion, cell migration, and planar cell polarity formation. Although Wnt5a signalin...

journal_title：EMBO reports

authors： Kikuchi K,Nakamura A,Arata M,Shi D,Nakagawa M,Tanaka T,Uemura T,Fujimori T,Kikuchi A,Uezu A,Sakamoto Y,Nakanishi H

更新日期：2018-07-01 00:00:00

abstract：:We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms...

journal_title：EMBO reports

authors： Lingel A,Simon B,Izaurralde E,Sattler M

更新日期：2005-12-01 00:00:00

abstract：:Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that...

journal_title：EMBO reports

authors： Ptushkina M,Malys N,McCarthy JE

更新日期：2004-03-01 00:00:00

abstract：:Streptococcus pneumoniae causes more than one million deaths every year, mostly of young children in developing countries, due to pneumonia, bacteremia and meningitis. The emergence and dissemination of drug-resistant pneumococcal strains, coupled to changing patterns of virulence and the inadequacy of available vacci...

journal_title：EMBO reports

authors： Di Guilmi AM,Dessen A

更新日期：2002-08-01 00:00:00