Abstract:
:Elongation of the telomeric overhang by telomerase is counteracted by synthesis of the complementary strand by the CST complex, CTC1(Cdc13)/Stn1/Ten1. Interaction of budding yeast Stn1 with overhang-binding Cdc13 is increased by Cdc13 SUMOylation. Human and fission yeast CST instead interact with overhang-binding TPP1/POT1. We show that the fission yeast TPP1 ortholog, Tpz1, is SUMOylated. Tpz1 SUMOylation restricts telomere elongation and promotes Stn1/Ten1 telomere association, and a SUMO-Tpz1 fusion protein has increased affinity for Stn1. Our data suggest that SUMO inhibits telomerase through stimulation of Stn1/Ten1 action by Tpz1, highlighting the evolutionary conservation of the regulation of CST function by SUMOylation.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Garg M,Gurung RL,Mansoubi S,Ahmed JO,Davé A,Watts FZ,Bianchi Adoi
10.15252/embr.201438919subject
Has Abstractpub_date
2014-08-01 00:00:00pages
871-7issue
8eissn
1469-221Xissn
1469-3178pii
embr.201438919journal_volume
15pub_type
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