Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2.

abstract：:The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto-inhibition. However, the molecular mechanism underlying Nedd4 E3 auto-inhibition and activation is poorly un...

journal_title：EMBO reports

authors： Zhu K,Shan Z,Chen X,Cai Y,Cui L,Yao W,Wang Z,Shi P,Tian C,Lou J,Xie Y,Wen W

更新日期：2017-09-01 00:00:00

abstract：:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...

journal_title：EMBO reports

authors： Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao M

更新日期：2013-02-01 00:00:00

abstract：:Small non-coding miRNA appear to be vital in brain development and function by organising complex patterns of gene expression. These molecules are important for the regulation of synaptically localised mRNAs that encode proteins involved in neurotransmission and behaviour. In this issue of EMBO Reports, Lackinger et a...

journal_title：EMBO reports

authors： Cairns MJ

更新日期：2019-02-01 00:00:00

abstract：:Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5/Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5-null mouse em...

journal_title：EMBO reports

authors： Poncet N,Halley PA,Lipina C,Gierliński M,Dady A,Singer GA,Febrer M,Shi YB,Yamaguchi TP,Taylor PM,Storey KG

更新日期：2020-01-07 00:00:00

abstract：:Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (...

journal_title：EMBO reports

authors： Chung J,Nakatsu F,Baskin JM,De Camilli P

更新日期：2015-03-01 00:00:00

abstract：:The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redundantly in the gut, as only simultaneous loss of both receptors r...

journal_title：EMBO reports

authors： Riccio O,van Gijn ME,Bezdek AC,Pellegrinet L,van Es JH,Zimber-Strobl U,Strobl LJ,Honjo T,Clevers H,Radtke F

更新日期：2008-04-01 00:00:00

abstract：:Ligands for nuclear receptors facilitate the exchange of co-repressors for coactivators, leading to chromatin modifications that favour the activation of gene transcription. Here, we show that the repressed state of an endogenous retinoic acid-regulated gene is quickly re-established after ligand removal. As expected,...

journal_title：EMBO reports

authors： Hartman HB,Yu J,Alenghat T,Ishizuka T,Lazar MA

更新日期：2005-05-01 00:00:00

abstract：:Recruitment of beta-arrestin (beta-arr) to agonist-stimulated G-protein-coupled receptors (GPCRs) has a crucial role in controlling signalling efficacy and selectivity. When translocated to the receptor, beta-arr is believed to undergo important conformational rearrangement necessary for its downstream actions. To pro...

journal_title：EMBO reports

authors： Charest PG,Terrillon S,Bouvier M

更新日期：2005-04-01 00:00:00

abstract：:Somatic hypermutation of immunoglobulin variable genes, which increases antibody diversity, is initiated by the activation-induced cytosine deaminase (AID) protein. The current DNA-deamination model posits that AID deaminates cytosine to uracil in DNA, and that mutations are generated by DNA polymerases during replica...

journal_title：EMBO reports

authors： Seki M,Gearhart PJ,Wood RD

更新日期：2005-12-01 00:00:00

abstract：:Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for th...

journal_title：EMBO reports

authors： Zezula J,Casaccia-Bonnefil P,Ezhevsky SA,Osterhout DJ,Levine JM,Dowdy SF,Chao MV,Koff A

更新日期：2001-01-01 00:00:00

abstract：:Despite its limited resources, Portugal has gained a prominent position in research on malaria. Several historical and personal factors have contributed to this achievement. ...

journal_title：EMBO reports

authors： Prudêncio M

更新日期：2021-01-10 00:00:00

abstract：:GlpF, the glycerol facilitator protein of Escherichia coli, is an archetypal member of the aquaporin superfamily. To assess its structure, recombinant histidine-tagged protein was overexpressed, solubilized in octylglucoside and purified to homogeneity. Negative stain electron microscopy of solubilized GlpF protein re...

journal_title：EMBO reports

authors： Braun T,Philippsen A,Wirtz S,Borgnia MJ,Agre P,Kühlbrandt W,Engel A,Stahlberg H

更新日期：2000-08-01 00:00:00

abstract：:Individuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3'-5' DNA helicase, and is a member...

journal_title：EMBO reports

authors： Constantinou A,Tarsounas M,Karow JK,Brosh RM,Bohr VA,Hickson ID,West SC

更新日期：2000-07-01 00:00:00

abstract：:Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...

journal_title：EMBO reports

authors： Guo J,Polymenis M

更新日期：2006-11-01 00:00:00

abstract：:The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...

journal_title：EMBO reports

authors： Mak DO,Pearson JE,Loong KP,Datta S,Fernández-Mongil M,Foskett JK

更新日期：2007-11-01 00:00:00

abstract：:SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in re...

journal_title：EMBO reports

authors： Saura A,Iribarren PA,Rojas-Barros D,Bart JM,López-Farfán D,Andrés-León E,Vidal-Cobo I,Boehm C,Alvarez VE,Field MC,Navarro M

更新日期：2019-12-05 00:00:00

abstract：:The accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the Unfolded Protein Response (UPR(ER)) to restore ER homeostasis. The AAA(+) ATPase p97/CDC-48 plays key roles in ER stress by promoting both ER protein degradation and transcription of UPR(ER) genes. Although the mechanisms associated...

journal_title：EMBO reports

authors： Marza E,Taouji S,Barroso K,Raymond AA,Guignard L,Bonneu M,Pallares-Lupon N,Dupuy JW,Fernandez-Zapico ME,Rosenbaum J,Palladino F,Dupuy D,Chevet E

更新日期：2015-03-01 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR)-catalyzed adenosine-to-inosine RNA editing is potentially dysregulated in neoplastic progression. However, how this transcriptome recoding process is functionally correlated with tumorigenesis remains largely elusive. Our analyses of RNA editome datasets identify hypoxia-relate...

journal_title：EMBO reports

authors： Ma CP,Liu H,Yi-Feng Chang I,Wang WC,Chen YT,Wu SM,Chen HW,Kuo YP,Shih CT,Li CY,Tan BC

更新日期：2019-05-01 00:00:00

abstract：:Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. Addition of inhibitors of GSK3β and MEK (so-called 2i conditions) pushes ESC cultures toward a more homogeneous naïve pluripotent state, but the molecular unde...

journal_title：EMBO reports

authors： Welling M,Chen HH,Muñoz J,Musheev MU,Kester L,Junker JP,Mischerikow N,Arbab M,Kuijk E,Silberstein L,Kharchenko PV,Geens M,Niehrs C,van de Velde H,van Oudenaarden A,Heck AJ,Geijsen N

更新日期：2015-07-01 00:00:00

abstract：:The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the ce...

journal_title：EMBO reports

authors： Okada M,Takezawa S,Mezaki Y,Yamaoka I,Takada I,Kitagawa H,Kato S

更新日期：2008-06-01 00:00:00

abstract：:Mitochondria play a central role in stem cell homeostasis. Reversible switching between aerobic and anaerobic metabolism is critical for stem cell quiescence, multipotency, and differentiation, as well as for cell reprogramming. However, the effect of mitochondrial dysfunction on neural stem cell (NSC) function is uns...

journal_title：EMBO reports

authors： Díaz-Castro B,Pardal R,García-Flores P,Sobrino V,Durán R,Piruat JI,López-Barneo J

更新日期：2015-11-01 00:00:00

abstract：:The highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show ...

journal_title：EMBO reports

authors： Picollo A,Liantonio A,Didonna MP,Elia L,Camerino DC,Pusch M

更新日期：2004-06-01 00:00:00

abstract：:Mitochondrial respiration generates an electrochemical proton gradient across the mitochondrial inner membrane called protonmotive force (PMF) to drive diverse functions and synthesize ATP. Current techniques to manipulate the PMF are limited to its dissipation; yet, there is no precise and reversible method to increa...

journal_title：EMBO reports

authors： Berry BJ,Trewin AJ,Milliken AS,Baldzizhar A,Amitrano AM,Lim Y,Kim M,Wojtovich AP

更新日期：2020-04-03 00:00:00

abstract：:Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts...

journal_title：EMBO reports

authors： Nava P,Capaldo CT,Koch S,Kolegraff K,Rankin CR,Farkas AE,Feasel ME,Li L,Addis C,Parkos CA,Nusrat A

更新日期：2011-04-01 00:00:00

abstract：:The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling. In this study, phenotype analysis of knockin/knockout Lgr5-eGFP-IRES-Cre and Lgr5-DTReGFP embryos reveals that Lgr5 deficiency during Wnt-mediated cytodifferentiation results in amplification of ISCs and early differe...

journal_title：EMBO reports

authors： Fernandez Vallone V,Leprovots M,Ribatallada-Soriano D,Gerbier R,Lefort A,Libert F,Vassart G,Garcia MI

更新日期：2020-07-03 00:00:00

abstract：:Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that...

journal_title：EMBO reports

authors： Ptushkina M,Malys N,McCarthy JE

更新日期：2004-03-01 00:00:00

abstract：:Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production...

journal_title：EMBO reports

authors： Hamieh A,Cartier D,Abid H,Calas A,Burel C,Bucharles C,Jehan C,Grumolato L,Landry M,Lerouge P,Anouar Y,Lihrmann I

更新日期：2017-11-01 00:00:00

abstract：:The systematic recording and management of experimental data in academic life science research remains an open problem. EPFL engaged in a program of ELN/LIMS deployment 6 years ago, encountering a host of fundamental questions at the institutional level and in each single laboratory. Here, based on our experience we a...

journal_title：EMBO reports

authors： Argento N

更新日期：2020-03-04 00:00:00

abstract：:Given that ligand binding is essential for the rapid internalization of epidermal growth factor receptor (EGFR), the events induced by ligand binding probably contribute to the regulation of EGFR internalization. These events include receptor dimerization, activation of intrinsic tyrosine kinase activity and autophosp...

journal_title：EMBO reports

authors： Wang Q,Villeneuve G,Wang Z

更新日期：2005-10-01 00:00:00

abstract：:Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expression of distinct estroge...

journal_title：EMBO reports

authors： Moggs JG,Orphanides G

更新日期：2001-09-01 00:00:00