Endogenous electric currents might guide rostral migration of neuroblasts.


:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.




EMBO reports


Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao M




Has Abstract


2013-02-01 00:00:00














  • Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores.

    abstract::Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation and for assembling fully functional kinetochores. Here, we used vertebrate cells conditionally ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Vagnarelli P,Morrison C,Dodson H,Sonoda E,Takeda S,Earnshaw WC

    更新日期:2004-02-01 00:00:00

  • Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway.

    abstract::Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and biochemical studies using a variety of different model systems have led to the discovery of 23 PEX genes required for this process. Although it is generally believed that, in contrast to mitochondria and chloroplasts, translocati...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Einwächter H,Sowinski S,Kunau WH,Schliebs W

    更新日期:2001-11-01 00:00:00

  • Replication-independent chromatin loading of Dnmt1 during G2 and M phases.

    abstract::The major DNA methyltransferase, Dnmt1, associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand. In view of the slow kinetics of Dnmt1 in vitro versus the fast progression of the replication fork, we have tested whether Dnmt1 associates with chromatin beyond...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Easwaran HP,Schermelleh L,Leonhardt H,Cardoso MC

    更新日期:2004-12-01 00:00:00

  • Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV.

    abstract::Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV). The role of TRPML1 in cell function and how the mutations cause the disease are not well understood. Most studies focus on the role of TRPML1 in constitutive membrane trafficking to and from the lysosomes. However, this cannot explai...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Park S,Ahuja M,Kim MS,Brailoiu GC,Jha A,Zeng M,Baydyuk M,Wu LG,Wassif CA,Porter FD,Zerfas PM,Eckhaus MA,Brailoiu E,Shin DM,Muallem S

    更新日期:2016-02-01 00:00:00

  • Brown adipocyte glucose metabolism: a heated subject.

    abstract::The energy expending and glucose sink properties of brown adipose tissue (BAT) make it an attractive target for new obesity and diabetes treatments. Despite decades of research, only recently have mechanistic studies started to provide a more complete and consistent picture of how activated brown adipocytes handle glu...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审


    authors: Hankir MK,Klingenspor M

    更新日期:2018-09-01 00:00:00

  • Chromosome misalignments induce spindle-positioning defects.

    abstract::Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus-end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein-dependent spindle positioning. However, the mechanism of how Spindly regul...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Tame MA,Raaijmakers JA,Afanasyev P,Medema RH

    更新日期:2016-03-01 00:00:00

  • Cytochrome c-d regulates developmental apoptosis in the Drosophila retina.

    abstract::The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Mendes CS,Arama E,Brown S,Scherr H,Srivastava M,Bergmann A,Steller H,Mollereau B

    更新日期:2006-09-01 00:00:00

  • NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission.

    abstract::Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms resi...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Saeed S,Tremp AZ,Sharma V,Lasonder E,Dessens JT

    更新日期:2020-03-04 00:00:00

  • Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene.

    abstract::Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector-parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA) knockout approach to determine the function of the mosquito antimicrobial peptide gene Defensin. We injected dsRNA into adul...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Blandin S,Moita LF,Köcher T,Wilm M,Kafatos FC,Levashina EA

    更新日期:2002-09-01 00:00:00

  • Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.

    abstract::Hydrogen sulfide (H2 S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis. By using xenograft orthotopic implantation of prostate cancer PC3 cells and subsequently comparing bone ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Wang YH,Huang JT,Chen WL,Wang RH,Kao MC,Pan YR,Chan SH,Tsai KW,Kung HJ,Lin KT,Wang LH

    更新日期:2019-10-04 00:00:00

  • A conserved element in Myc that negatively regulates its proapoptotic activity.

    abstract::Myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. Analysis of highly conserved elements within vertebrate Myc proteins has been instrumental in defining the functions of the Myc protein. Here, we probe the role of a highly conserved, but little studied, element within the centr...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Herbst A,Hemann MT,Tworkowski KA,Salghetti SE,Lowe SW,Tansey WP

    更新日期:2005-02-01 00:00:00

  • Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

    abstract::Recruitment of beta-arrestin (beta-arr) to agonist-stimulated G-protein-coupled receptors (GPCRs) has a crucial role in controlling signalling efficacy and selectivity. When translocated to the receptor, beta-arr is believed to undergo important conformational rearrangement necessary for its downstream actions. To pro...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Charest PG,Terrillon S,Bouvier M

    更新日期:2005-04-01 00:00:00

  • c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.

    abstract::The bacterium Bacillus subtilis produces the DNA integrity scanning protein (DisA), a checkpoint protein that delays sporulation in response to DNA damage. DisA scans the chromosome and pauses at sites of DNA lesions. Structural analysis showed that DisA synthesizes the small molecule cyclic diadenosine monophosphate ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Oppenheimer-Shaanan Y,Wexselblatt E,Katzhendler J,Yavin E,Ben-Yehuda S

    更新日期:2011-06-01 00:00:00

  • The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase.

    abstract::The eukaryotic GINS complex has an essential role in the initiation and elongation phases of genome duplication. It is composed of four paralogous subunits--Sld5, Psf1, Psf2 and Psf3--which are ubiquitous and evolutionarily conserved in eukaryotic organisms. Here, we report the biochemical characterization of the huma...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: De Falco M,Ferrari E,De Felice M,Rossi M,Hübscher U,Pisani FM

    更新日期:2007-01-01 00:00:00

  • Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.

    abstract::The highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Picollo A,Liantonio A,Didonna MP,Elia L,Camerino DC,Pusch M

    更新日期:2004-06-01 00:00:00

  • The 3.7 A projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer.

    abstract::GlpF, the glycerol facilitator protein of Escherichia coli, is an archetypal member of the aquaporin superfamily. To assess its structure, recombinant histidine-tagged protein was overexpressed, solubilized in octylglucoside and purified to homogeneity. Negative stain electron microscopy of solubilized GlpF protein re...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Braun T,Philippsen A,Wirtz S,Borgnia MJ,Agre P,Kühlbrandt W,Engel A,Stahlberg H

    更新日期:2000-08-01 00:00:00

  • Estrogen receptors: orchestrators of pleiotropic cellular responses.

    abstract::Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expression of distinct estroge...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审


    authors: Moggs JG,Orphanides G

    更新日期:2001-09-01 00:00:00

  • The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

    abstract::Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the 'oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity to cellular hypoxia, the ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Masson N,Singleton RS,Sekirnik R,Trudgian DC,Ambrose LJ,Miranda MX,Tian YM,Kessler BM,Schofield CJ,Ratcliffe PJ

    更新日期:2012-03-01 00:00:00

  • Secured cutting: controlling separase at the metaphase to anaphase transition.

    abstract::The final irreversible step in the duplication and distribution of genomes to daughter cells takes place at the metaphase to anaphase transition. At this point aligned sister chromatid pairs split and separate. During metaphase, cohesion between sister chromatids is maintained by the chromosomal multi-subunit cohesin ...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审


    authors: Uhlmann F

    更新日期:2001-06-01 00:00:00

  • The UBL domain of PLIC-1 regulates aggresome formation.

    abstract::Defects in protein folding and the proteasomal pathway have been linked with many neurodegenerative diseases. PLIC-1 (protein linking IAP to the cytoskeleton) is a ubiquitin-like protein that binds to the ubiquitin-interacting motif (UIM) of the proteasomal subunit S5a. Here, we show that PLIC-1 also binds to the UIM ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Heir R,Ablasou C,Dumontier E,Elliott M,Fagotto-Kaufmann C,Bedford FK

    更新日期:2006-12-01 00:00:00

  • Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.

    abstract::Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis may be critical for controlling diverse biological processes includin...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: De Gassart A,Demaria O,Panes R,Zaffalon L,Ryazanov AG,Gilliet M,Martinon F

    更新日期:2016-10-01 00:00:00

  • ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.

    abstract::The tumour suppressor ARF (alternative reading frame), which is mutated or silenced in various tumours, has a crucial role in tumour surveillance to suppress unwarranted cell growth and proliferation. ARF has also been linked to the DNA-damage-induced response of p53 because of its ability to inhibit murine double min...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Dominguez-Brauer C,Chen YJ,Brauer PM,Pimkina J,Raychaudhuri P

    更新日期:2009-09-01 00:00:00

  • Signalling in space and time: systems dynamics of intracellular communication.

    abstract::The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

    journal_title:EMBO reports



    authors: Tzlil S,Kuruvilla R

    更新日期:2011-09-01 00:00:00

  • eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress-response factor.

    abstract::Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Ptushkina M,Malys N,McCarthy JE

    更新日期:2004-03-01 00:00:00

  • Involvement of state transitions in the switch between linear and cyclic electron flow in Chlamydomonas reinhardtii.

    abstract::The energetic metabolism of photosynthetic organisms is profoundly influenced by state transitions and cyclic electron flow around photosystem I. The former involve a reversible redistribution of the light-harvesting antenna between photosystem I and photosystem II and optimize light energy utilization in photosynthes...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Finazzi G,Rappaport F,Furia A,Fleischmann M,Rochaix JD,Zito F,Forti G

    更新日期:2002-03-01 00:00:00

  • Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

    abstract::N6-methyladenosine (m6A) is a highly dynamic RNA modification that has recently emerged as a key regulator of gene expression. While many m6A modifications are installed by the METTL3-METTL14 complex, others appear to be introduced independently, implying that additional human m6A methyltransferases remain to be ident...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

    更新日期:2017-11-01 00:00:00

  • If you promise, you have to deliver.

    abstract::COVID-19 highlighted the importance of science and scientists to produce vaccines, cures and diagnostics. But scientists need to be careful not to overpromise on what they can deliver. ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Gannon F

    更新日期:2020-11-05 00:00:00

  • Lipoic acid and autophagy: new insights into stem cell aging.

    abstract::The gastrointestinal tract undergoes homeostatic self-renewal to replace aged and damaged epithelial cells. This process, sustained by intestinal stem cells (ISCs), can operate accurately for many years but gradually declines with age. Although stem cell aging has been intensively explored, the mechanisms remain poorl...

    journal_title:EMBO reports

    pub_type: 评论,新闻


    authors: Zhang P,Edgar BA

    更新日期:2020-08-05 00:00:00

  • New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.

    abstract::Streptococcus pneumoniae causes more than one million deaths every year, mostly of young children in developing countries, due to pneumonia, bacteremia and meningitis. The emergence and dissemination of drug-resistant pneumococcal strains, coupled to changing patterns of virulence and the inadequacy of available vacci...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审


    authors: Di Guilmi AM,Dessen A

    更新日期:2002-08-01 00:00:00

  • Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress.

    abstract::The denitrosylase S-nitrosoglutathione reductase (GSNOR) has been suggested to sustain mitochondrial removal by autophagy (mitophagy), functionally linking S-nitrosylation to cell senescence and aging. In this study, we provide evidence that GSNOR is induced at the translational level in response to hydrogen peroxide ...

    journal_title:EMBO reports

    pub_type: 杂志文章


    authors: Cirotti C,Rizza S,Giglio P,Poerio N,Allega MF,Claps G,Pecorari C,Lee JH,Benassi B,Barilà D,Robert C,Stamler JS,Cecconi F,Fraziano M,Paull TT,Filomeni G

    更新日期:2020-11-27 00:00:00