Abstract:
:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao Mdoi
10.1038/embor.2012.215subject
Has Abstractpub_date
2013-02-01 00:00:00pages
184-90issue
2eissn
1469-221Xissn
1469-3178pii
embor2012215journal_volume
14pub_type
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