Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.

abstract：:Loss of the retinoblastoma protein, pRB, leads to apoptosis, and several results have suggested that this is dependent on the E2F transcription factors. However, so far, the ability of the different E2F family members to contribute to apoptosis is controversial. Here, we show that ectopic expression of E2F3 results in...

journal_title：EMBO reports

authors： Lazzerini Denchi E,Helin K

更新日期：2005-07-01 00:00:00

abstract：:Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

journal_title：EMBO reports

authors： Harris RE,Ashe HL

更新日期：2011-06-01 00:00:00

abstract：:N6-methyladenosine (m6A) is a highly dynamic RNA modification that has recently emerged as a key regulator of gene expression. While many m6A modifications are installed by the METTL3-METTL14 complex, others appear to be introduced independently, implying that additional human m6A methyltransferases remain to be ident...

journal_title：EMBO reports

authors： Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

更新日期：2017-11-01 00:00:00

abstract：:Synaptic vesicles fuse with the plasma membrane in response to Ca(2+) influx, thereby releasing neurotransmitters into the synaptic cleft. The protein machinery that mediates this process, consisting of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and regulatory proteins, is well kno...

journal_title：EMBO reports

authors： Bharat TA,Malsam J,Hagen WJ,Scheutzow A,Söllner TH,Briggs JA

更新日期：2014-03-01 00:00:00

abstract：:The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...

journal_title：EMBO reports

authors： Ahuja M,Muallem S

更新日期：2014-03-01 00:00:00

abstract：:Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...

journal_title：EMBO reports

authors： Fritsch L,Martinez LA,Sekhri R,Naguibneva I,Gérard M,Vandromme M,Schaeffer L,Harel-Bellan A

更新日期：2004-02-01 00:00:00

abstract：:When our time comes to die most people would probably opt for a quick, peaceful and painless exit. But the manner and timing are rarely under our direct control. Hence the Ars moriendi, literally, "The Art of Dying", two texts written in Latin around the 15th century that offered advice on how to die well according to...

journal_title：EMBO reports

authors： Murphy JM,Silke J

更新日期：2014-02-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have relied mainly on the use of commercial Staphylococcus aureus PG and have not addressed TLR2 recognition of other PG type...

journal_title：EMBO reports

authors： Travassos LH,Girardin SE,Philpott DJ,Blanot D,Nahori MA,Werts C,Boneca IG

更新日期：2004-10-01 00:00:00

abstract：:In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulati...

journal_title：EMBO reports

authors： Shim HS,Kim H,Lee J,Son GH,Cho S,Oh TH,Kang SH,Seen DS,Lee KH,Kim K

更新日期：2007-04-01 00:00:00

abstract：:Loss of primary cilia is a key feature of von Hippel-Lindau tumor suppressor (VHL)-associated pathology. Although VHL-deficiency predisposes cells to precipitous cilia disassembly in response to growth factor cues, it does not affect ciliogenesis. Here, using a siRNA-based screen to find genes that are essential for c...

journal_title：EMBO reports

authors： Troilo A,Alexander I,Muehl S,Jaramillo D,Knobeloch KP,Krek W

更新日期：2014-01-01 00:00:00

abstract：:Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production...

journal_title：EMBO reports

authors： Hamieh A,Cartier D,Abid H,Calas A,Burel C,Bucharles C,Jehan C,Grumolato L,Landry M,Lerouge P,Anouar Y,Lihrmann I

更新日期：2017-11-01 00:00:00

abstract：:In Drosophila, the piRNA cluster, flamenco, produces most of the piRNAs (PIWI-interacting RNAs) that silence transposable elements in the somatic follicle cells during oogenesis. These piRNAs are thought to be processed from a long single-stranded precursor transcript. Here, we demonstrate that flamenco transcription ...

journal_title：EMBO reports

authors： Goriaux C,Desset S,Renaud Y,Vaury C,Brasset E

更新日期：2014-04-01 00:00:00

abstract：:Very little is known about the biogenesis and assembly of oligomeric membrane proteins. In this study, the biogenesis of KcsA, a prokaryotic homotetrameric potassium channel, is investigated. Using in vivo pulse-chase experiments, both the monomeric and tetrameric form could be identified. The conversion of monomers i...

journal_title：EMBO reports

authors： van Dalen A,Schrempf H,Killian JA,de Kruijff B

更新日期：2000-10-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:The ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated by mammalian IRE1 cannot be fully explained by IRE1's one known, specific RNA target, X box-bi...

journal_title：EMBO reports

authors： Hamid SM,Citir M,Terzi EM,Cimen I,Yildirim Z,Dogan AE,Kocaturk B,Onat UI,Arditi M,Weber C,Traynor-Kaplan A,Schultz C,Erbay E

更新日期：2020-11-02 00:00:00

abstract：:Post-translational protein arginylation is essential for cardiovascular development and angiogenesis in mice and is mediated by arginyl-transfer RNA-protein transferases Ate1-a functionally conserved but poorly understood class of enzymes. Here, we used sequence analysis to detect the evolutionary relationship between...

journal_title：EMBO reports

authors： Rai R,Mushegian A,Makarova K,Kashina A

更新日期：2006-08-01 00:00:00

abstract：:Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation and for assembling fully functional kinetochores. Here, we used vertebrate cells conditionally ...

journal_title：EMBO reports

authors： Vagnarelli P,Morrison C,Dodson H,Sonoda E,Takeda S,Earnshaw WC

更新日期：2004-02-01 00:00:00

abstract：:WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway ...

journal_title：EMBO reports

authors： Kim YJ,Osborn DP,Lee JY,Araki M,Araki K,Mohun T,Känsäkoski J,Brandstack N,Kim HT,Miralles F,Kim CH,Brown NA,Kim HG,Martinez-Barbera JP,Ataliotis P,Raivio T,Layman LC,Kim SH

更新日期：2018-02-01 00:00:00

abstract：:Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis may be critical for controlling diverse biological processes includin...

journal_title：EMBO reports

authors： De Gassart A,Demaria O,Panes R,Zaffalon L,Ryazanov AG,Gilliet M,Martinon F

更新日期：2016-10-01 00:00:00

abstract：:The delta2 glutamate receptor (GluRdelta2) has a crucial role in cerebellar functions; disruption of GluRdelta2 alleles in mice (delta2(-/-)) impairs synapse formation and long-term depression, which is thought to underlie motor learning in the cerebellum, and consequently leads to motor discoordination. However, it h...

journal_title：EMBO reports

authors： Hirai H,Miyazaki T,Kakegawa W,Matsuda S,Mishina M,Watanabe M,Yuzaki M

更新日期：2005-01-01 00:00:00

abstract：:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

journal_title：EMBO reports

authors： Smythe E,Ayscough KR

更新日期：2003-03-01 00:00:00

abstract：:The function of protein phosphatase 1 nuclear-targeting subunit (PNUTS)--one of the most abundant nuclear-targeting subunits of protein phosphatase 1 (PP1c)--remains largely uncharacterized. We show that PNUTS depletion by small interfering RNA activates a G2 checkpoint in unperturbed cells and prolongs G2 checkpoint ...

journal_title：EMBO reports

authors： Landsverk HB,Mora-Bermúdez F,Landsverk OJ,Hasvold G,Naderi S,Bakke O,Ellenberg J,Collas P,Syljuåsen RG,Küntziger T

更新日期：2010-11-01 00:00:00

abstract：:Endo180, also known as the urokinase plasminogen activator receptor (uPAR)-associated protein (uPARAP), is one of the four members of the mannose receptor family, and is implicated in extracellular-matrix remodelling through its interactions with collagens, sugars and uPAR. The extracellular portion of Endo180 contain...

journal_title：EMBO reports

authors： Rivera-Calzada A,Robertson D,MacFadyen JR,Boskovic J,Isacke CM,Llorca O

更新日期：2003-08-01 00:00:00

abstract：:β-arrestin 1 and 2 (also known as arrestin 2 and 3) are homologous adaptor proteins that regulate seven-transmembrane receptor trafficking and signalling. Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulatio...

journal_title：EMBO reports

authors： Han SO,Kommaddi RP,Shenoy SK

更新日期：2013-02-01 00:00:00

abstract：:Although many signal transduction pathways have been implicated in the development of human disease, the identification of pathway targets and the biological processes that mediate disease progression remains challenging. One such disease-related pathway is the Janus kinase (JAK)/signal transducer and activator of tra...

journal_title：EMBO reports

authors： Bina S,Wright VM,Fisher KH,Milo M,Zeidler MP

更新日期：2010-03-01 00:00:00

abstract：:A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential ...

journal_title：EMBO reports

authors： Cokol M,Nair R,Rost B

更新日期：2000-11-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:The crystal structure of the ligand-binding domain of RARbeta, a suspect tumour suppressor, reveals important features that distinguish it from the two other RAR isotypes. The most striking difference is an extra cavity allowing RARbeta to bind more bulky agonists. Accordingly, we identified a ligand that shows RARbet...

journal_title：EMBO reports

authors： Germain P,Kammerer S,Pérez E,Peluso-Iltis C,Tortolani D,Zusi FC,Starrett J,Lapointe P,Daris JP,Marinier A,de Lera AR,Rochel N,Gronemeyer H

更新日期：2004-09-01 00:00:00

abstract：:CLIP-170/Restin belongs to a family of conserved microtubule (MT)-associated proteins, which are important for MT organization and functions. CLIP-170 is a phosphoprotein and phosphorylation is thought to regulate the binding of CLIP-170 to MTs. However, little is known about the kinase(s) involved. In this study, we ...

journal_title：EMBO reports

authors： Choi JH,Bertram PG,Drenan R,Carvalho J,Zhou HH,Zheng XF

更新日期：2002-10-01 00:00:00

abstract：:In Drosophila melanogaster males, X-chromosome monosomy is compensated by chromosome-wide transcription activation. We found that complete dosage compensation during embryogenesis takes surprisingly long and is incomplete even after 10 h of development. Although the activating dosage compensation complex (DCC) associa...

journal_title：EMBO reports

authors： Prayitno K,Schauer T,Regnard C,Becker PB

更新日期：2019-08-01 00:00:00