Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death.

abstract：:Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold...

journal_title：EMBO reports

authors： Uhlmann F

更新日期：2009-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have significant side effects. A...

journal_title：EMBO reports

authors： Ploss A,Rice CM

更新日期：2009-11-01 00:00:00

abstract：:RNA modifications represent a novel layer of regulation of gene expression. Functional experiments revealed that N6 -methyladenosine (m6 A) on messenger RNA (mRNA) plays critical roles in cell fate determination and development. m6 A mark also resides in the decoding center of 18S ribosomal RNA (rRNA); however, the bi...

journal_title：EMBO reports

authors： Xing M,Liu Q,Mao C,Zeng H,Zhang X,Zhao S,Chen L,Liu M,Shen B,Guo X,Ma H,Chen H,Zhang J

更新日期：2020-10-05 00:00:00

abstract：:The mechanism by which YopP simultaneously inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB pathways has been elusive. Ectopic expression of YopP inhibits the activity and ubiquitination of a complex consisting of overexpressed TGF-beta-activated kinase 1 (TAK1) and its subunit TAK1-binding p...

journal_title：EMBO reports

authors： Thiefes A,Wolf A,Doerrie A,Grassl GA,Matsumoto K,Autenrieth I,Bohn E,Sakurai H,Niedenthal R,Resch K,Kracht M

更新日期：2006-08-01 00:00:00

abstract：:Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

journal_title：EMBO reports

authors： Fernandez-Capetillo O

更新日期：2010-01-01 00:00:00

abstract：:X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...

journal_title：EMBO reports

authors： Ng K,Pullirsch D,Leeb M,Wutz A

更新日期：2007-01-01 00:00:00

abstract：:In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 antibody or expression of dominant-negative Rac1N17 led to an inversion ...

journal_title：EMBO reports

authors： Yu W,Shewan AM,Brakeman P,Eastburn DJ,Datta A,Bryant DM,Fan QW,Weiss WA,Zegers MM,Mostov KE

更新日期：2008-09-01 00:00:00

abstract：:Autophagosome formation is promoted by the PI3 kinase complex and negatively regulated by myotubularin phosphatases, indicating that regulation of local phosphatidylinositol 3-phosphate (PtdIns3P) levels is important for this early phase of autophagy. Here, we show that the Caenorhabditis elegans myotubularin phosphat...

journal_title：EMBO reports

authors： Wu Y,Cheng S,Zhao H,Zou W,Yoshina S,Mitani S,Zhang H,Wang X

更新日期：2014-09-01 00:00:00

abstract：:The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate...

journal_title：EMBO reports

authors： Ady V,Perroy J,Tricoire L,Piochon C,Dadak S,Chen X,Dusart I,Fagni L,Lambolez B,Levenes C

更新日期：2014-01-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms resi...

journal_title：EMBO reports

authors： Saeed S,Tremp AZ,Sharma V,Lasonder E,Dessens JT

更新日期：2020-03-04 00:00:00

abstract：:Zika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by w...

journal_title：EMBO reports

authors： Tiwari SK,Dang JW,Lin N,Qin Y,Wang S,Rana TM

更新日期：2020-10-19 00:00:00

abstract：:The denitrosylase S-nitrosoglutathione reductase (GSNOR) has been suggested to sustain mitochondrial removal by autophagy (mitophagy), functionally linking S-nitrosylation to cell senescence and aging. In this study, we provide evidence that GSNOR is induced at the translational level in response to hydrogen peroxide ...

journal_title：EMBO reports

authors： Cirotti C,Rizza S,Giglio P,Poerio N,Allega MF,Claps G,Pecorari C,Lee JH,Benassi B,Barilà D,Robert C,Stamler JS,Cecconi F,Fraziano M,Paull TT,Filomeni G

更新日期：2020-11-27 00:00:00

abstract：:Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that...

journal_title：EMBO reports

authors： Ptushkina M,Malys N,McCarthy JE

更新日期：2004-03-01 00:00:00

abstract：:The gastrointestinal tract undergoes homeostatic self-renewal to replace aged and damaged epithelial cells. This process, sustained by intestinal stem cells (ISCs), can operate accurately for many years but gradually declines with age. Although stem cell aging has been intensively explored, the mechanisms remain poorl...

journal_title：EMBO reports

authors： Zhang P,Edgar BA

更新日期：2020-08-05 00:00:00

abstract：:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...

journal_title：EMBO reports

authors： Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao M

更新日期：2013-02-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...

journal_title：EMBO reports

authors： Sordet O,Redon CE,Guirouilh-Barbat J,Smith S,Solier S,Douarre C,Conti C,Nakamura AJ,Das BB,Nicolas E,Kohn KW,Bonner WM,Pommier Y

更新日期：2009-08-01 00:00:00

abstract：:The histone H3 N-terminal protein domain (N-tail) is regulated by multiple posttranslational modifications, including methylation, acetylation, phosphorylation, and by proteolytic cleavage. However, the mechanism underlying H3 N-tail proteolytic cleavage is largely elusive. Here, we report that JMJD5, a Jumonji C (Jmj...

journal_title：EMBO reports

authors： Shen J,Xiang X,Chen L,Wang H,Wu L,Sun Y,Ma L,Gu X,Liu H,Wang L,Yu YN,Shao J,Huang C,Chin YE

更新日期：2017-12-01 00:00:00

abstract：:The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...

journal_title：EMBO reports

authors： Bomar MG,Pai MT,Tzeng SR,Li SS,Zhou P

更新日期：2007-03-01 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:The first EMBO Conference on Experimental Approaches to Evolution and Ecology in Yeast was held in Heidelberg, Germany, at the end of September 2010. What might sound like a rather narrow topic actually covered a broad range of interests, approaches, and systems and generated a great deal of excitement among participa...

journal_title：EMBO reports

authors： Dunham MJ,Louis EJ

更新日期：2011-01-01 00:00:00

abstract：:The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...

journal_title：EMBO reports

authors： Russo A,Goel P,Brace EJ,Buser C,Dickman D,DiAntonio A

更新日期：2019-03-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD). Mitophagy, a cargo-specific autophagy for elimination of dysfunctional mitochondria, constitutes a key quality control mechanism. However, ho...

journal_title：EMBO reports

authors： Han S,Jeong YY,Sheshadri P,Su X,Cai Q

更新日期：2020-09-03 00:00:00

abstract：:RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prior work revealed that intestinal epithelial cell-specific Imp1 deletio...

journal_title：EMBO reports

authors： Chatterji P,Williams PA,Whelan KA,Samper FC,Andres SF,Simon LA,Parham LR,Mizuno R,Lundsmith ET,Lee DS,Liang S,Wijeratne HS,Marti S,Chau L,Giroux V,Wilkins BJ,Wu GD,Shah P,Tartaglia GG,Hamilton KE

更新日期：2019-06-01 00:00:00

abstract：:The COVID-19 crisis has further highlighted the challenges for open science and data sharing in biomedical research and the need for more traceability and transparency. ...

journal_title：EMBO reports

authors： Minari J,Yoshizawa G,Shinomiya N

更新日期：2020-11-05 00:00:00

abstract：:Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs interact with the ALTERNATIVE SPLICING COMPETITOR (ASCO) lncRNA. Here, we analyze the effect of ...

journal_title：EMBO reports

authors： Rigo R,Bazin J,Romero-Barrios N,Moison M,Lucero L,Christ A,Benhamed M,Blein T,Huguet S,Charon C,Crespi M,Ariel F

更新日期：2020-05-06 00:00:00

abstract：:Chloroplast genes of higher plants are transcribed by two types of RNA polymerase that are encoded by nuclear (NEP (nuclear-encoded plastid RNA polymerase)) or plastid (PEP (plastid-encoded plastid RNA polymerase)) genomes. NEP is largely responsible for the transcription of housekeeping genes during early chloroplast...

journal_title：EMBO reports

authors： Hanaoka M,Kanamaru K,Fujiwara M,Takahashi H,Tanaka K

更新日期：2005-06-01 00:00:00

abstract：:Although many signal transduction pathways have been implicated in the development of human disease, the identification of pathway targets and the biological processes that mediate disease progression remains challenging. One such disease-related pathway is the Janus kinase (JAK)/signal transducer and activator of tra...

journal_title：EMBO reports

authors： Bina S,Wright VM,Fisher KH,Milo M,Zeidler MP

更新日期：2010-03-01 00:00:00

abstract：:The race for a vaccine against SARS-CoV-2 has accelerated research on RNA-based therapeutics. Beyond vaccines, RNA also shows great potential for cancer therapies. ...

journal_title：EMBO reports

authors： Rinaldi A

更新日期：2020-07-03 00:00:00

abstract：:Paxillin is a protein containing four LIM domains, and functions in integrin signaling. We report here that two transcripts are generated from the paxillin gene locus in Drosophila; one encodes a protein homolog of the vertebrate Paxillin (DPxn37), and the other a protein with only three LIM domains, partly encoded by...

journal_title：EMBO reports

authors： Yagi R,Ishimaru S,Yano H,Gaul U,Hanafusa H,Sabe H

更新日期：2001-09-01 00:00:00