Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.

abstract：:The energy expending and glucose sink properties of brown adipose tissue (BAT) make it an attractive target for new obesity and diabetes treatments. Despite decades of research, only recently have mechanistic studies started to provide a more complete and consistent picture of how activated brown adipocytes handle glu...

journal_title：EMBO reports

authors： Hankir MK,Klingenspor M

更新日期：2018-09-01 00:00:00

abstract：:Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological a...

journal_title：EMBO reports

authors： Lopez-Mejia IC,de Toledo M,Chavey C,Lapasset L,Cavelier P,Lopez-Herrera C,Chebli K,Fort P,Beranger G,Fajas L,Amri EZ,Casas F,Tazi J

更新日期：2014-05-01 00:00:00

abstract：:The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated a significant number of clones in the public databases, as a result of the use of the transposon in bacterial cloning st...

journal_title：EMBO reports

authors： Hill F,Gemünd C,Benes V,Ansorge W,Gibson TJ

更新日期：2000-07-01 00:00:00

abstract：:RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6 A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear RNA. Recently, several m6 A methyltransferases were identified, unco...

journal_title：EMBO reports

authors： Leismann J,Spagnuolo M,Pradhan M,Wacheul L,Vu MA,Musheev M,Mier P,Andrade-Navarro MA,Graille M,Niehrs C,Lafontaine DL,Roignant JY

更新日期：2020-07-03 00:00:00

abstract：:Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus-end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein-dependent spindle positioning. However, the mechanism of how Spindly regul...

journal_title：EMBO reports

authors： Tame MA,Raaijmakers JA,Afanasyev P,Medema RH

更新日期：2016-03-01 00:00:00

abstract：:The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism a...

journal_title：EMBO reports

authors： Cappellen D,Schlange T,Bauer M,Maurer F,Hynes NE

更新日期：2007-01-01 00:00:00

abstract：:In response to a variety of stresses, mammalian cells undergo a persistent proliferative arrest known as cellular senescence. Many senescence-inducing stressors are potentially oncogenic, strengthening the notion that senescence evolved alongside apoptosis to suppress tumorigenesis. In contrast to apoptosis, senescent...

journal_title：EMBO reports

authors： Childs BG,Baker DJ,Kirkland JL,Campisi J,van Deursen JM

更新日期：2014-11-01 00:00:00

abstract：:The highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show ...

journal_title：EMBO reports

authors： Picollo A,Liantonio A,Didonna MP,Elia L,Camerino DC,Pusch M

更新日期：2004-06-01 00:00:00

abstract：:KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl- ) extruder critical for hyperpolarizing GABAA receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular inter...

journal_title：EMBO reports

authors： Mavrovic M,Uvarov P,Delpire E,Vutskits L,Kaila K,Puskarjov M

更新日期：2020-04-03 00:00:00

abstract：:Labmates are colleagues, friends, comforters…and competitors. ...

journal_title：EMBO reports

authors： Morriswood B,Hoeller O

更新日期：2019-07-01 00:00:00

abstract：:During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial functio...

journal_title：EMBO reports

authors： Mazzoni C,Herker E,Palermo V,Jungwirth H,Eisenberg T,Madeo F,Falcone C

更新日期：2005-11-01 00:00:00

abstract：:At gastrulation, a subpopulation of epiblast cells constitutes a transient posteriorly located structure called the primitive streak, where cells that undergo epithelial-mesenchymal transition make up the mesoderm and endoderm lineages. Mouse embryo epiblast cells were labelled ubiquitously or in a mosaic fashion. Cel...

journal_title：EMBO reports

authors： Mathiah N,Despin-Guitard E,Stower M,Nahaboo W,Eski ES,Singh SP,Srinivas S,Migeotte I

更新日期：2020-11-05 00:00:00

abstract：:A-kinase (or PKA)-anchoring protein AKAP95 is a zinc-finger protein implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. We have identified determinants of chromatin-binding, condensin-targeting and chromosome-condensation activities of AKAP95. Binding of AKAP95 to...

journal_title：EMBO reports

authors： Eide T,Carlson C,Taskén KA,Hirano T,Taskén K,Collas P

更新日期：2002-05-01 00:00:00

abstract：:In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly ...

journal_title：EMBO reports

authors： Boye E,Løbner-Olesen A,Skarstad K

更新日期：2000-12-01 00:00:00

abstract：:The major DNA methyltransferase, Dnmt1, associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand. In view of the slow kinetics of Dnmt1 in vitro versus the fast progression of the replication fork, we have tested whether Dnmt1 associates with chromatin beyond...

journal_title：EMBO reports

authors： Easwaran HP,Schermelleh L,Leonhardt H,Cardoso MC

更新日期：2004-12-01 00:00:00

abstract：:The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously reported that expression of KV10.1 i...

journal_title：EMBO reports

authors： Sánchez A,Urrego D,Pardo LA

更新日期：2016-05-01 00:00:00

abstract：:An effective immune response requires the engagement of host receptors by pathogen-derived molecules and the stimulation of an appropriate cellular response. Therefore, a crucial factor in our ability to control an infection is the accessibility of our immune cells to the foreign material. Exosomes-which are extracell...

journal_title：EMBO reports

authors： Schorey JS,Cheng Y,Singh PP,Smith VL

更新日期：2015-01-01 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:The high-mobility-group B (HMGB) chromosomal proteins are characterized by the HMG box, a DNA-binding domain that both introduces a tight bend into DNA and binds preferentially to a variety of distorted DNA structures. The HMGB proteins seem to act primarily as architectural facilitators in the manipulation of nucleop...

journal_title：EMBO reports

authors： Travers AA

更新日期：2003-02-01 00:00:00

abstract：:The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a...

journal_title：EMBO reports

authors： Nitta T,Muro R,Shimizu Y,Nitta S,Oda H,Ohte Y,Goto M,Yanobu-Takanashi R,Narita T,Takayanagi H,Yasuda H,Okamura T,Murata S,Suzuki H

更新日期：2015-05-01 00:00:00

abstract：:The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhae...

journal_title：EMBO reports

authors： Loenarz C,Coleman ML,Boleininger A,Schierwater B,Holland PW,Ratcliffe PJ,Schofield CJ

更新日期：2011-01-01 00:00:00

abstract：:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

journal_title：EMBO reports

authors： Smythe E,Ayscough KR

更新日期：2003-03-01 00:00:00

abstract：:DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...

journal_title：EMBO reports

authors： Arias-Lopez C,Lazaro-Trueba I,Kerr P,Lord CJ,Dexter T,Iravani M,Ashworth A,Silva A

更新日期：2006-02-01 00:00:00

abstract：:The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...

journal_title：EMBO reports

authors： Bomar MG,Pai MT,Tzeng SR,Li SS,Zhou P

更新日期：2007-03-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to...

journal_title：EMBO reports

authors： Sakamoto K,Furuichi Y,Yamamoto M,Takahashi M,Akimoto Y,Ishikawa T,Shimizu T,Fujimoto M,Takada-Watanabe A,Hayashi A,Mita Y,Manabe Y,Fujii NL,Ishibashi R,Maezawa Y,Betsholtz C,Yokote K,Takemoto M

更新日期：2019-11-05 00:00:00

abstract：:Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...

journal_title：EMBO reports

authors： Yan WW,Liang YL,Zhang QX,Wang D,Lei MZ,Qu J,He XH,Lei QY,Wang YP

更新日期：2018-12-01 00:00:00

abstract：:The cytoplasm is the main place for protein translation from where nascent proteins are transported to their working areas, including the inside, outside, and membrane of the cell. The majority of newly synthesized membrane proteins is co-translationally inserted into the membrane by the evolutionary conserved Sec tra...

journal_title：EMBO reports

authors： Tanaka Y,Tsukazaki T

更新日期：2019-10-04 00:00:00

abstract：:Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000-4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. T...

journal_title：EMBO reports

authors： Capelson M,Hetzer MW

更新日期：2009-07-01 00:00:00

abstract：:The function of protein phosphatase 1 nuclear-targeting subunit (PNUTS)--one of the most abundant nuclear-targeting subunits of protein phosphatase 1 (PP1c)--remains largely uncharacterized. We show that PNUTS depletion by small interfering RNA activates a G2 checkpoint in unperturbed cells and prolongs G2 checkpoint ...

journal_title：EMBO reports

authors： Landsverk HB,Mora-Bermúdez F,Landsverk OJ,Hasvold G,Naderi S,Bakke O,Ellenberg J,Collas P,Syljuåsen RG,Küntziger T

更新日期：2010-11-01 00:00:00