Abstract:
:The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism and cell proliferation, and can, depending on the cells, promote or inhibit migration. We identified new c-MYC target genes in these cell lines, and show that selective regulation of some targets correlates with the phenotypic responses of these different cell lines to c-MYC depletion. Notably, we show that a positive regulation of the WNT signalling pathway contributes to c-MYC pro-mitogenic effects in breast and cervix carcinoma cells. We also show that repression of CCL5/RANTES accounts for c-MYC anti-migratory effects in specific breast cancer cells. Our combined genomic and phenotypic analysis indicates that c-MYC functions are cellular-context-dependent and that selectively regulated genes are responsible for its differential properties.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Cappellen D,Schlange T,Bauer M,Maurer F,Hynes NEdoi
10.1038/sj.embor.7400849subject
Has Abstractpub_date
2007-01-01 00:00:00pages
70-6issue
1eissn
1469-221Xissn
1469-3178pii
7400849journal_volume
8pub_type
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