The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.

Abstract:

:The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.

journal_name

EMBO Rep

journal_title

EMBO reports

authors

Loenarz C,Coleman ML,Boleininger A,Schierwater B,Holland PW,Ratcliffe PJ,Schofield CJ

doi

10.1038/embor.2010.170

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

63-70

issue

1

eissn

1469-221X

issn

1469-3178

pii

embor2010170

journal_volume

12

pub_type

杂志文章
  • The dichotomy of yield and draught resistance: Translation challenges from basic research to crop adaptation to climate change.

    abstract::Global climate change and the increasing human population require crop varieties with higher yield and draught resistance. But meeting both goals is not an easy task for breeders and plant science. ...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.202051598

    authors: Moshelion M

    更新日期:2020-11-29 00:00:00

  • Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae.

    abstract::Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400813

    authors: Guo J,Polymenis M

    更新日期:2006-11-01 00:00:00

  • The interface between the ubiquitin family and the DNA damage response.

    abstract::The crucial role of ubiquitin signalling in genome-integrity maintenance was first recognized in 1987 by Stefan Jentsch and Alex Varshavsky, who showed that Rad6-the repair protein involved in DNA damage tolerance-is a ubiquitin-conjugating enzyme. Although this discovery inspired extensive research and led to the dis...

    journal_title:EMBO reports

    pub_type:

    doi:10.1038/embor.2010.180

    authors: Lukas J

    更新日期:2010-12-01 00:00:00

  • Cease and desist: modulating short-range Dpp signalling in the stem-cell niche.

    abstract::Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审

    doi:10.1038/embor.2011.80

    authors: Harris RE,Ashe HL

    更新日期:2011-06-01 00:00:00

  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.

    abstract::β-arrestin 1 and 2 (also known as arrestin 2 and 3) are homologous adaptor proteins that regulate seven-transmembrane receptor trafficking and signalling. Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulatio...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/embor.2012.187

    authors: Han SO,Kommaddi RP,Shenoy SK

    更新日期:2013-02-01 00:00:00

  • Intrauterine programming of ageing.

    abstract::Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/embor.2009.262

    authors: Fernandez-Capetillo O

    更新日期:2010-01-01 00:00:00

  • The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila.

    abstract::RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6 A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear RNA. Recently, several m6 A methyltransferases were identified, unco...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201949443

    authors: Leismann J,Spagnuolo M,Pradhan M,Wacheul L,Vu MA,Musheev M,Mier P,Andrade-Navarro MA,Graille M,Niehrs C,Lafontaine DL,Roignant JY

    更新日期:2020-07-03 00:00:00

  • Effects of reciprocal chromosomal translocations on the fitness of Saccharomyces cerevisiae.

    abstract::Yeast species have undergone extensive genome reorganization in their evolutionary history, including variations in chromosome number and large chromosomal rearrangements, such as translocations. To determine directly the contribution of chromosomal translocations to the whole organism's fitness, we devised a strategy...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400123

    authors: Colson I,Delneri D,Oliver SG

    更新日期:2004-04-01 00:00:00

  • PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

    abstract::Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1093/embo-reports/kvf242

    authors: Munier AI,Doucet D,Perrodou E,Zachary D,Meister M,Hoffmann JA,Janeway CA Jr,Lagueux M

    更新日期:2002-12-01 00:00:00

  • Vesicle sub-pool organization at inner hair cell ribbon synapses.

    abstract::The afferent inner hair cell synapse harbors the synaptic ribbon, which ensures a constant vesicle supply. Synaptic vesicles (SVs) are arranged in morphologically discernable pools, linked via filaments to the ribbon or the presynaptic membrane. We propose that filaments play a major role in SV resupply and exocytosis...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201744937

    authors: Chakrabarti R,Michanski S,Wichmann C

    更新日期:2018-11-01 00:00:00

  • The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton.

    abstract::The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审

    doi:10.1038/sj.embor.embor776

    authors: Smythe E,Ayscough KR

    更新日期:2003-03-01 00:00:00

  • Novel c-MYC target genes mediate differential effects on cell proliferation and migration.

    abstract::The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism a...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400849

    authors: Cappellen D,Schlange T,Bauer M,Maurer F,Hynes NE

    更新日期:2007-01-01 00:00:00

  • Molecular dissection of arginyltransferases guided by similarity to bacterial peptidoglycan synthases.

    abstract::Post-translational protein arginylation is essential for cardiovascular development and angiogenesis in mice and is mediated by arginyl-transfer RNA-protein transferases Ate1-a functionally conserved but poorly understood class of enzymes. Here, we used sequence analysis to detect the evolutionary relationship between...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400747

    authors: Rai R,Mushegian A,Makarova K,Kashina A

    更新日期:2006-08-01 00:00:00

  • Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation.

    abstract::Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of re...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1093/embo-reports/kvf066

    authors: Lefebvre B,Ozato K,Lefebvre P

    更新日期:2002-04-01 00:00:00

  • Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth.

    abstract::The ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated by mammalian IRE1 cannot be fully explained by IRE1's one known, specific RNA target, X box-bi...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.202051462

    authors: Hamid SM,Citir M,Terzi EM,Cimen I,Yildirim Z,Dogan AE,Kocaturk B,Onat UI,Arditi M,Weber C,Traynor-Kaplan A,Schultz C,Erbay E

    更新日期:2020-11-02 00:00:00

  • RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

    abstract::In Saccharomyces cerevisiae, genome stability depends on RNases H1 and H2, which remove ribonucleotides from DNA and eliminate RNA-DNA hybrids (R-loops). In Schizosaccharomyces pombe, RNase H enzymes were reported to process RNA-DNA hybrids produced at a double-strand break (DSB) generated by I-PpoI meganuclease. Howe...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201745335

    authors: Zhao H,Zhu M,Limbo O,Russell P

    更新日期:2018-05-01 00:00:00

  • R3hdml regulates satellite cell proliferation and differentiation.

    abstract::In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201947957

    authors: Sakamoto K,Furuichi Y,Yamamoto M,Takahashi M,Akimoto Y,Ishikawa T,Shimizu T,Fujimoto M,Takada-Watanabe A,Hayashi A,Mita Y,Manabe Y,Fujii NL,Ishibashi R,Maezawa Y,Betsholtz C,Yokote K,Takemoto M

    更新日期:2019-11-05 00:00:00

  • Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.

    abstract::While the genome sequence and gene content are available for an increasing number of organisms, eukaryotic selenoproteins remain poorly characterized. The dual role of the UGA codon confounds the identification of novel selenoprotein genes. Here, we describe a comparative genomics approach that relies on the genome-wi...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400036

    authors: Castellano S,Novoselov SV,Kryukov GV,Lescure A,Blanco E,Krol A,Gladyshev VN,Guigó R

    更新日期:2004-01-01 00:00:00

  • Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavage.

    abstract::It has been suggested that DNA methylation/demethylation is involved in regulating V(D)J rearrangement. Although methylated DNA is thought to induce an inaccessible chromatin structure, it is unclear whether DNA methylation can directly control V(D)J recombination independently of chromatin structure. In this study, w...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.embor904

    authors: Nakase H,Takahama Y,Akamatsu Y

    更新日期:2003-08-01 00:00:00

  • Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila.

    abstract::We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means of a P-element insertional genetic screen. Helicase89B belongs to the Mot1p/BTAF1 subfamily of SNF2-like ATPases. This subfamily can interact with TATA-binding proteins, but whethe...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400542

    authors: Yagi Y,Ip YT

    更新日期:2005-11-01 00:00:00

  • The Iron age of host-microbe interactions.

    abstract::Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize th...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审

    doi:10.15252/embr.201540558

    authors: Soares MP,Weiss G

    更新日期:2015-11-01 00:00:00

  • A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP.

    abstract::Like many transcription regulators, histone methyltransferases G9a and G9a-like protein (GLP) can act gene-specifically as coregulators, but mechanisms controlling this specificity are mostly unknown. We show that adjacent post-translational methylation and phosphorylation regulate binding of G9a and GLP to heterochro...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201744060

    authors: Poulard C,Bittencourt D,Wu DY,Hu Y,Gerke DS,Stallcup MR

    更新日期:2017-08-01 00:00:00

  • Estrogen receptors: orchestrators of pleiotropic cellular responses.

    abstract::Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expression of distinct estroge...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审

    doi:10.1093/embo-reports/kve185

    authors: Moggs JG,Orphanides G

    更新日期:2001-09-01 00:00:00

  • Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm.

    abstract::Retinoic acid (RA) signalling ensures that vertebrate mesoderm segmentation is bilaterally synchronized, and corrects transient interferences from asymmetric left-right (L-R) signals involved in organ lateralization. Snail genes participate in both these processes and, although they are expressed symmetrically in the ...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400867

    authors: Morales AV,Acloque H,Ocaña OH,de Frutos CA,Gold V,Nieto MA

    更新日期:2007-01-01 00:00:00

  • The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.

    abstract::The mechanism by which YopP simultaneously inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB pathways has been elusive. Ectopic expression of YopP inhibits the activity and ubiquitination of a complex consisting of overexpressed TGF-beta-activated kinase 1 (TAK1) and its subunit TAK1-binding p...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.7400754

    authors: Thiefes A,Wolf A,Doerrie A,Grassl GA,Matsumoto K,Autenrieth I,Bohn E,Sakurai H,Niedenthal R,Resch K,Kracht M

    更新日期:2006-08-01 00:00:00

  • Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology.

    abstract::Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiol...

    journal_title:EMBO reports

    pub_type: 杂志文章,评审

    doi:10.1038/embor.2011.139

    authors: Fu Y,Rubin CS

    更新日期:2011-07-08 00:00:00

  • Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

    abstract::We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted beta-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induce...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1038/sj.embor.embor865

    authors: van de Wetering M,Oving I,Muncan V,Pon Fong MT,Brantjes H,van Leenen D,Holstege FC,Brummelkamp TR,Agami R,Clevers H

    更新日期:2003-06-01 00:00:00

  • Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.

    abstract::Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201847407

    authors: Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

    更新日期:2019-04-01 00:00:00

  • Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer.

    abstract::Caspase-3 is a crucial component of the apoptotic machinery in many cell types. Here, we report the timescale of caspase-3 activation in single living cells undergoing apoptosis. This was achieved by measuring the extent of fluorescence resonance energy transfer within a recombinant substrate containing cyan fluoresce...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.1093/embo-reports/kvd050

    authors: Tyas L,Brophy VA,Pope A,Rivett AJ,Tavaré JM

    更新日期:2000-09-01 00:00:00

  • The 18S rRNA m6 A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.

    abstract::RNA modifications represent a novel layer of regulation of gene expression. Functional experiments revealed that N6 -methyladenosine (m6 A) on messenger RNA (mRNA) plays critical roles in cell fate determination and development. m6 A mark also resides in the decoding center of 18S ribosomal RNA (rRNA); however, the bi...

    journal_title:EMBO reports

    pub_type: 杂志文章

    doi:10.15252/embr.201949863

    authors: Xing M,Liu Q,Mao C,Zeng H,Zhang X,Zhao S,Chen L,Liu M,Shen B,Guo X,Ma H,Chen H,Zhang J

    更新日期:2020-10-05 00:00:00