Abstract:
:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evolution of Ark/Prk family members in different organisms may have allowed the conserved role of the kinase domain, which is required for the phosphorylation of both endocytic and cytoskeletal components, to be coupled to other functional domains.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Smythe E,Ayscough KRdoi
10.1038/sj.embor.embor776keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
246-51issue
3eissn
1469-221Xissn
1469-3178pii
embor776journal_volume
4pub_type
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