Abstract:
:Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize their pathogenic impact. Host defense strategies that limit microbial pathogenicity include resistance mechanisms that exert a negative impact on microbes, and disease tolerance mechanisms that sustain host homeostasis without interfering directly with microbes. While genetically distinct, these host defense strategies are functionally integrated, via mechanisms that remain incompletely defined. Here, we explore the general principles via which host adaptive responses regulating iron (Fe) metabolism impact on resistance and disease tolerance to infection.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Soares MP,Weiss Gdoi
10.15252/embr.201540558subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1482-500issue
11eissn
1469-221Xissn
1469-3178pii
embr.201540558journal_volume
16pub_type
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