PHF6 promotes non-homologous end joining and G2 checkpoint recovery.

abstract：:The crystal structure of the ligand-binding domain of RARbeta, a suspect tumour suppressor, reveals important features that distinguish it from the two other RAR isotypes. The most striking difference is an extra cavity allowing RARbeta to bind more bulky agonists. Accordingly, we identified a ligand that shows RARbet...

journal_title：EMBO reports

authors： Germain P,Kammerer S,Pérez E,Peluso-Iltis C,Tortolani D,Zusi FC,Starrett J,Lapointe P,Daris JP,Marinier A,de Lera AR,Rochel N,Gronemeyer H

更新日期：2004-09-01 00:00:00

abstract：:When our time comes to die most people would probably opt for a quick, peaceful and painless exit. But the manner and timing are rarely under our direct control. Hence the Ars moriendi, literally, "The Art of Dying", two texts written in Latin around the 15th century that offered advice on how to die well according to...

journal_title：EMBO reports

authors： Murphy JM,Silke J

更新日期：2014-02-01 00:00:00

abstract：:LeuT serves as the model protein for understanding the relationships between structure, mechanism and pharmacology in neurotransmitter sodium symporters (NSSs). At the present time, however, there is a vigorous debate over whether there is a single high-affinity substrate site (S1) located at the original, crystallogr...

journal_title：EMBO reports

authors： Wang H,Gouaux E

更新日期：2012-09-01 00:00:00

abstract：:The race for a vaccine against SARS-CoV-2 has accelerated research on RNA-based therapeutics. Beyond vaccines, RNA also shows great potential for cancer therapies. ...

journal_title：EMBO reports

authors： Rinaldi A

更新日期：2020-07-03 00:00:00

abstract：:Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. ...

journal_title：EMBO reports

authors： Sousa C,Golebiewska A,Poovathingal SK,Kaoma T,Pires-Afonso Y,Martina S,Coowar D,Azuaje F,Skupin A,Balling R,Biber K,Niclou SP,Michelucci A

更新日期：2018-11-01 00:00:00

abstract：:Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi-protein complex is activated by supernumerary centrosomes to induce p53 and restrict proliferation of polyplo...

journal_title：EMBO reports

authors： Sladky VC,Knapp K,Szabo TG,Braun VZ,Bongiovanni L,van den Bos H,Spierings DC,Westendorp B,Curinha A,Stojakovic T,Scharnagl H,Timelthaler G,Tsuchia K,Pinter M,Semmler G,Foijer F,de Bruin A,Reiberger T,Rohr-Udilova N,

更新日期：2020-11-23 00:00:00

abstract：:KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl- ) extruder critical for hyperpolarizing GABAA receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular inter...

journal_title：EMBO reports

authors： Mavrovic M,Uvarov P,Delpire E,Vutskits L,Kaila K,Puskarjov M

更新日期：2020-04-03 00:00:00

abstract：:The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling. In this study, phenotype analysis of knockin/knockout Lgr5-eGFP-IRES-Cre and Lgr5-DTReGFP embryos reveals that Lgr5 deficiency during Wnt-mediated cytodifferentiation results in amplification of ISCs and early differe...

journal_title：EMBO reports

authors： Fernandez Vallone V,Leprovots M,Ribatallada-Soriano D,Gerbier R,Lefort A,Libert F,Vassart G,Garcia MI

更新日期：2020-07-03 00:00:00

abstract：:Tie2, an endothelial cell-specific receptor kinase, has an important role in tumour angiogenesis. In an attempt to identify peptides that specifically interact with and block the Tie2 pathway, a phage-displayed peptide library was screened on a recombinant Tie2 receptor. One peptide, NLLMAAS, completely abolished the ...

journal_title：EMBO reports

authors： Tournaire R,Simon MP,le Noble F,Eichmann A,England P,Pouysségur J

更新日期：2004-03-01 00:00:00

abstract：:Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome-dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of autophagosomes and lys...

journal_title：EMBO reports

authors： Wang Y,Huang Y,Liu J,Zhang J,Xu M,You Z,Peng C,Gong Z,Liu W

更新日期：2020-01-07 00:00:00

abstract：:Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin can itself be phosphorylated at nearly every serine, threonine, and tyrosine residue. However, the effect of this modification on ubiquitin function is largely unknown....

journal_title：EMBO reports

authors： Swaney DL,Rodríguez-Mias RA,Villén J

更新日期：2015-09-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:The Drosophila immune system is able to discriminate between classes of bacteria. Detection of Gram-positive bacteria involves a complex of two pattern recognition receptors: peptidoglycan recognition protein SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1). These activate the Toll signalling pathway. To defin...

journal_title：EMBO reports

authors： Filipe SR,Tomasz A,Ligoxygakis P

更新日期：2005-04-01 00:00:00

abstract：:A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential ...

journal_title：EMBO reports

authors： Cokol M,Nair R,Rost B

更新日期：2000-11-01 00:00:00

abstract：:The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated. Specifically, the precise contribution o...

journal_title：EMBO reports

authors： Bonora M,Morganti C,Morciano G,Pedriali G,Lebiedzinska-Arciszewska M,Aquila G,Giorgi C,Rizzo P,Campo G,Ferrari R,Kroemer G,Wieckowski MR,Galluzzi L,Pinton P

更新日期：2017-07-01 00:00:00

abstract：:The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate...

journal_title：EMBO reports

authors： Ady V,Perroy J,Tricoire L,Piochon C,Dadak S,Chen X,Dusart I,Fagni L,Lambolez B,Levenes C

更新日期：2014-01-01 00:00:00

abstract：:Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...

journal_title：EMBO reports

authors： Fritsch L,Martinez LA,Sekhri R,Naguibneva I,Gérard M,Vandromme M,Schaeffer L,Harel-Bellan A

更新日期：2004-02-01 00:00:00

abstract：:Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize th...

journal_title：EMBO reports

authors： Soares MP,Weiss G

更新日期：2015-11-01 00:00:00

abstract：:The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that ...

journal_title：EMBO reports

authors： Gras S,Chaumont V,Fernandez B,Carpentier P,Charrier-Savournin F,Schmitt S,Pineau C,Flament D,Hecker A,Forterre P,Armengaud J,Housset D

更新日期：2007-06-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for th...

journal_title：EMBO reports

authors： Zezula J,Casaccia-Bonnefil P,Ezhevsky SA,Osterhout DJ,Levine JM,Dowdy SF,Chao MV,Koff A

更新日期：2001-01-01 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have relied mainly on the use of commercial Staphylococcus aureus PG and have not addressed TLR2 recognition of other PG type...

journal_title：EMBO reports

authors： Travassos LH,Girardin SE,Philpott DJ,Blanot D,Nahori MA,Werts C,Boneca IG

更新日期：2004-10-01 00:00:00

abstract：:Zika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by w...

journal_title：EMBO reports

authors： Tiwari SK,Dang JW,Lin N,Qin Y,Wang S,Rana TM

更新日期：2020-10-19 00:00:00

abstract：:WHITE COLLAR-1 (WC-1) is the limiting component of the White Collar Complex (WCC) controlling expression of the Neurospora circadian clock protein Frequency (FRQ). Accumulation of WC-1 is supported by FRQ on a post-transcriptional level. Here, we show that transcription of wc-1 is organized in a complex way. Three pro...

journal_title：EMBO reports

authors： Káldi K,González BH,Brunner M

更新日期：2006-02-01 00:00:00

abstract：:COVID-19 highlighted the importance of science and scientists to produce vaccines, cures and diagnostics. But scientists need to be careful not to overpromise on what they can deliver. ...

journal_title：EMBO reports

authors： Gannon F

更新日期：2020-11-05 00:00:00

abstract：:The EMBO conference 'From Structure to Function of Translocation Machines' took place in April 2013 in Dubrovnik, Croatia. The meeting brought together a mix of established and aspiring researchers to discuss a wealth of unpublished data and ideas in a lively scientific programme of talks designed to shatter the estab...

journal_title：EMBO reports

authors： Lithgow T,Waksman G

更新日期：2013-07-01 00:00:00

abstract：:Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (...

journal_title：EMBO reports

authors： Chung J,Nakatsu F,Baskin JM,De Camilli P

更新日期：2015-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) originate from stemloop-forming precursor RNAs found in longer primary transcripts that often contain introns. We show that in plants, those introns, when located 3' of the stemloop, can promote mature miRNA accumulation, through a mechanism that likely operates at the level of miRNA processing or s...

journal_title：EMBO reports

authors： Schwab R,Speth C,Laubinger S,Voinnet O

更新日期：2013-07-01 00:00:00

abstract：:Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase (LCK) and FYN oncogene related to SRC, FGR, YES (FYN) mediate GC-induced inhibition of T-cell-receptor (TCR) signalling. Her...

journal_title：EMBO reports

authors： Löwenberg M,Verhaar AP,Bilderbeek J,Marle Jv,Buttgereit F,Peppelenbosch MP,van Deventer SJ,Hommes DW

更新日期：2006-10-01 00:00:00