Abstract:
:MicroRNAs (miRNAs) originate from stemloop-forming precursor RNAs found in longer primary transcripts that often contain introns. We show that in plants, those introns, when located 3' of the stemloop, can promote mature miRNA accumulation, through a mechanism that likely operates at the level of miRNA processing or stability. Reversely, when miRNA production is reduced such as in dicer-like 1 mutants, splicing of introns that promote miRNA processing is considerably increased, pointing to a tight physical and temporal coordination of intron splicing and miRNA processing in plants. Our findings further suggest that miRNA transcripts without introns generated through alternative polyA-site usage might contribute to the differential adjustment of miRNA levels, possibly at a tissue-specific level.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Schwab R,Speth C,Laubinger S,Voinnet Odoi
10.1038/embor.2013.58subject
Has Abstractpub_date
2013-07-01 00:00:00pages
615-21issue
7eissn
1469-221Xissn
1469-3178pii
embor201358journal_volume
14pub_type
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