The interface between the ubiquitin family and the DNA damage response.

Abstract:

:The crucial role of ubiquitin signalling in genome-integrity maintenance was first recognized in 1987 by Stefan Jentsch and Alex Varshavsky, who showed that Rad6-the repair protein involved in DNA damage tolerance-is a ubiquitin-conjugating enzyme. Although this discovery inspired extensive research and led to the discovery of genome surveillance pathways that are fuelled by proteolytic and regulatory ubiquitylation and SUMOylation, it took more than two decades for these fields to meet at a dedicated interdisciplinary conference. This was rectified at an EMBO workshop held between 1 and 5 September on Red Island, Rovinj, Croatia.

journal_name

EMBO Rep

journal_title

EMBO reports

authors

Lukas J

doi

10.1038/embor.2010.180

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

907-9

issue

12

eissn

1469-221X

issn

1469-3178

pii

embor2010180

journal_volume

11

pub_type

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