Abstract:
:Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans- and autophosphorylation, as well as the subcellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Fu Y,Rubin CSdoi
10.1038/embor.2011.139subject
Has Abstractpub_date
2011-07-08 00:00:00pages
785-96issue
8eissn
1469-221Xissn
1469-3178pii
embor2011139journal_volume
12pub_type
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