Abstract:
:TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Durán RV,Hall MNdoi
10.1038/embor.2011.257subject
Has Abstractpub_date
2012-02-01 00:00:00pages
121-8issue
2eissn
1469-221Xissn
1469-3178pii
embor2011257journal_volume
13pub_type
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