Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.

abstract：:In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly ...

journal_title：EMBO reports

authors： Boye E,Løbner-Olesen A,Skarstad K

更新日期：2000-12-01 00:00:00

abstract：:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

journal_title：EMBO reports

authors： Smythe E,Ayscough KR

更新日期：2003-03-01 00:00:00

abstract：:The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In a...

journal_title：EMBO reports

authors： Colombo R,Boggio R,Seiser C,Draetta GF,Chiocca S

更新日期：2002-11-01 00:00:00

abstract：:CLIP-170/Restin belongs to a family of conserved microtubule (MT)-associated proteins, which are important for MT organization and functions. CLIP-170 is a phosphoprotein and phosphorylation is thought to regulate the binding of CLIP-170 to MTs. However, little is known about the kinase(s) involved. In this study, we ...

journal_title：EMBO reports

authors： Choi JH,Bertram PG,Drenan R,Carvalho J,Zhou HH,Zheng XF

更新日期：2002-10-01 00:00:00

abstract：:PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by f...

journal_title：EMBO reports

authors： Muñoz IM,Rouse J

更新日期：2009-03-01 00:00:00

abstract：:Processive motor proteins are stochastic steppers that perform actual mechanical steps for only a minor fraction of the time they are bound to the filament track. Motors usually work in teams and therefore the question arises whether the stochasticity of stepping can cause mutual interference when motors are mechanica...

journal_title：EMBO reports

authors： Bieling P,Telley IA,Piehler J,Surrey T

更新日期：2008-11-01 00:00:00

abstract：:The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated a significant number of clones in the public databases, as a result of the use of the transposon in bacterial cloning st...

journal_title：EMBO reports

authors： Hill F,Gemünd C,Benes V,Ansorge W,Gibson TJ

更新日期：2000-07-01 00:00:00

abstract：:Proteins of the Imp4/Brix superfamily are involved in ribosomal RNA processing, an essential function in all cells. We report the first structure of an Imp4/Brix superfamily protein, the Mil (for Methanothermobacter thermautotrophicus Imp4-like) protein (gene product Mth680), from the archaeon M. thermautotrophicus. T...

journal_title：EMBO reports

authors： Ng CL,Waterman D,Koonin EV,Antson AA,Ortiz-Lombardía M

更新日期：2005-02-01 00:00:00

abstract：:Very little is known about the biogenesis and assembly of oligomeric membrane proteins. In this study, the biogenesis of KcsA, a prokaryotic homotetrameric potassium channel, is investigated. Using in vivo pulse-chase experiments, both the monomeric and tetrameric form could be identified. The conversion of monomers i...

journal_title：EMBO reports

authors： van Dalen A,Schrempf H,Killian JA,de Kruijff B

更新日期：2000-10-01 00:00:00

abstract：:The Carma1-Bcl10-Malt1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical IkappaB kinase (IKK)/NF (nuclear factor)-kappaB pathway. Earlier studies have indicated that the COP9 signalosome (CSN), a pleiotropic regulator of the ubiquitin/26S proteasome system, controls antigen responses in T cells....

journal_title：EMBO reports

authors： Welteke V,Eitelhuber A,Düwel M,Schweitzer K,Naumann M,Krappmann D

更新日期：2009-06-01 00:00:00

abstract：:The Drosophila immune system is able to discriminate between classes of bacteria. Detection of Gram-positive bacteria involves a complex of two pattern recognition receptors: peptidoglycan recognition protein SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1). These activate the Toll signalling pathway. To defin...

journal_title：EMBO reports

authors： Filipe SR,Tomasz A,Ligoxygakis P

更新日期：2005-04-01 00:00:00

abstract：:Subcellular organization is yielding to large-scale analysis. Researchers are now applying robust mass-spectrometry-based proteomics methods to obtain an inventory of biochemically isolated organelles that contain hundreds of proteins. High-resolution methods allow accurate protein identification, and novel algorithms...

journal_title：EMBO reports

authors： Andersen JS,Mann M

更新日期：2006-09-01 00:00:00

abstract：:Histone demethylases-both lysine-specific demethylase 1 (LSD1) and Jumonji-C (JmjC) domain-containing proteins-are broadly implicated in the regulation of chromatin-dependent processes. In Arabidopsis thaliana, histone marks directly affect DNA methylation, and mutations in LSD1 homologues show reduced DNA methylation...

journal_title：EMBO reports

authors： Deleris A,Greenberg MV,Ausin I,Law RW,Moissiard G,Schubert D,Jacobsen SE

更新日期：2010-12-01 00:00:00

abstract：:The afferent inner hair cell synapse harbors the synaptic ribbon, which ensures a constant vesicle supply. Synaptic vesicles (SVs) are arranged in morphologically discernable pools, linked via filaments to the ribbon or the presynaptic membrane. We propose that filaments play a major role in SV resupply and exocytosis...

journal_title：EMBO reports

authors： Chakrabarti R,Michanski S,Wichmann C

更新日期：2018-11-01 00:00:00

abstract：:Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we report a role for MEK-dr...

journal_title：EMBO reports

authors： Byun JK,Park M,Yun JW,Lee J,Kim JS,Cho SJ,Lee YM,Lee IK,Choi YK,Park KG

更新日期：2019-06-01 00:00:00

abstract：:The imprint at the mat1 locus of Schizosaccharomyces pombe acts to initiate the replication-coupled recombination event that underlies mating-type switching. However, the nature of the imprint has been an area of dispute. Two alternative models have been proposed: one stated that the imprint is a nick in the DNA, wher...

journal_title：EMBO reports

authors： Vengrova S,Dalgaard JZ

更新日期：2006-01-01 00:00:00

abstract：:During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial functio...

journal_title：EMBO reports

authors： Mazzoni C,Herker E,Palermo V,Jungwirth H,Eisenberg T,Madeo F,Falcone C

更新日期：2005-11-01 00:00:00

abstract：:Sonic hedgehog (Shh), both as a mitogen and as a morphogen, plays an important role in cell proliferation and differentiation during early development. Here, we show that Shh inhibits glutamate transporter activities in neurons, rapidly enhances extracellular glutamate levels, and affects the development of epilepsy. ...

journal_title：EMBO reports

authors： Feng S,Ma S,Jia C,Su Y,Yang S,Zhou K,Liu Y,Cheng J,Lu D,Fan L,Wang Y

更新日期：2016-05-01 00:00:00

abstract：:Signal peptide peptidase (SPP) and the four homologous SPP-like (SPPL) proteases constitute a family of intramembrane aspartyl proteases with selectivity for type II-oriented transmembrane segments. Here, we analyse the physiological function of the orphan protease SPPL2c, previously considered to represent a non-expr...

journal_title：EMBO reports

authors： Niemeyer J,Mentrup T,Heidasch R,Müller SA,Biswas U,Meyer R,Papadopoulou AA,Dederer V,Haug-Kröper M,Adamski V,Lüllmann-Rauch R,Bergmann M,Mayerhofer A,Saftig P,Wennemuth G,Jessberger R,Fluhrer R,Lichtenthaler SF,Lember

更新日期：2019-03-01 00:00:00

abstract：:Cells suffer necrotic death when exposed to extreme environmental conditions, adverse and excessive stimuli, or when deleterious mutations are encoded in their genetic material. Unlike apoptosis, which involves a highly regulated and elaborate network of biochemical events and cascades, necrosis has been considered ge...

journal_title：EMBO reports

authors： Syntichaki P,Tavernarakis N

更新日期：2002-07-01 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:Around 100 researchers gathered at the eighteenth EMBO Conference on 'The Molecular and Developmental Biology of Drosophila', which took place in Crete in June 2012. Whether deconstructing or integrating at the genetic, cellular or organ level, the talks highlighted the synergy of combining methods, approaches and dis...

journal_title：EMBO reports

authors： Miguel-Aliaga I,Oliver B,Teleman AA

更新日期：2012-11-06 00:00:00

abstract：:Several mechanisms have been proposed for the synthesis of substrate-linked ubiquitin chains. HECT ligases directly catalyse protein ubiquitination and have been found to non-covalently interact with ubiquitin. We report crystal structures of the Nedd4 HECT domain, alone and in complex with ubiquitin, which show a new...

journal_title：EMBO reports

authors： Maspero E,Mari S,Valentini E,Musacchio A,Fish A,Pasqualato S,Polo S

更新日期：2011-04-01 00:00:00

abstract：:X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...

journal_title：EMBO reports

authors： Ng K,Pullirsch D,Leeb M,Wutz A

更新日期：2007-01-01 00:00:00

abstract：:The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library of chromatin regulators. We identified genes involved in chromatin remodeling, sister ch...

journal_title：EMBO reports

authors： Warmerdam DO,Alonso-de Vega I,Wiegant WW,van den Broek B,Rother MB,Wolthuis RM,Freire R,van Attikum H,Medema RH,Smits VA

更新日期：2020-01-07 00:00:00

abstract：:Sulphatases undergo a unique post-translational modification that converts a highly conserved cysteine located within their active site into formylglycine. This modification is necessary for the catalytic activities of the sulphatases, and it is generated by the protein product of sulphatase-modifying factor 1 (SUMF1)...

journal_title：EMBO reports

authors： Zito E,Fraldi A,Pepe S,Annunziata I,Kobinger G,Di Natale P,Ballabio A,Cosma MP

更新日期：2005-07-01 00:00:00

abstract：:The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the ce...

journal_title：EMBO reports

authors： Okada M,Takezawa S,Mezaki Y,Yamaoka I,Takada I,Kitagawa H,Kato S

更新日期：2008-06-01 00:00:00

abstract：:Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studi...

journal_title：EMBO reports

authors： Tatapudy S,Aloisio F,Barber D,Nystul T

更新日期：2017-12-01 00:00:00

abstract：:Pair-rule genes in Drosophila integrate the positional information provided by the transcription factor gradients of gap genes and set the framework for the expression of the segment polarity genes. Pair-rule genes are also expressed during the segmentation of the short germ-band embryo of the flour beetle Tribolium, ...

journal_title：EMBO reports

authors： Eckert C,Aranda M,Wolff C,Tautz D

更新日期：2004-06-01 00:00:00