Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation.

abstract：:Various aerolysin-like pore-forming proteins have been identified from bacteria to vertebrates. However, the mechanism of receptor recognition and/or pore formation of the eukaryotic members remains unknown. Here, we present the first crystal and electron microscopy structures of a vertebrate aerolysin-like protein fr...

journal_title：EMBO reports

authors： Jia N,Liu N,Cheng W,Jiang YL,Sun H,Chen LL,Peng J,Zhang Y,Ding YH,Zhang ZH,Wang X,Cai G,Wang J,Dong MQ,Zhang Z,Wu H,Wang HW,Chen Y,Zhou CZ

更新日期：2016-02-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have relied mainly on the use of commercial Staphylococcus aureus PG and have not addressed TLR2 recognition of other PG type...

journal_title：EMBO reports

authors： Travassos LH,Girardin SE,Philpott DJ,Blanot D,Nahori MA,Werts C,Boneca IG

更新日期：2004-10-01 00:00:00

abstract：:DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...

journal_title：EMBO reports

authors： Arias-Lopez C,Lazaro-Trueba I,Kerr P,Lord CJ,Dexter T,Iravani M,Ashworth A,Silva A

更新日期：2006-02-01 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR)-catalyzed adenosine-to-inosine RNA editing is potentially dysregulated in neoplastic progression. However, how this transcriptome recoding process is functionally correlated with tumorigenesis remains largely elusive. Our analyses of RNA editome datasets identify hypoxia-relate...

journal_title：EMBO reports

authors： Ma CP,Liu H,Yi-Feng Chang I,Wang WC,Chen YT,Wu SM,Chen HW,Kuo YP,Shih CT,Li CY,Tan BC

更新日期：2019-05-01 00:00:00

abstract：:Epidermal growth factor (EGF) activates the EGF receptor (EGFR) and stimulates its internalization and trafficking to lysosomes for degradation. However, a percentage of EGFR undergoes ligand-independent endocytosis and is rapidly recycled back to the plasma membrane. Importantly, alterations in EGFR recycling are a c...

journal_title：EMBO reports

authors： Ioannou MS,Kulasekaran G,Fotouhi M,Morein JJ,Han C,Tse S,Nossova N,Han T,Mannard E,McPherson PS

更新日期：2017-12-01 00:00:00

abstract：:During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial functio...

journal_title：EMBO reports

authors： Mazzoni C,Herker E,Palermo V,Jungwirth H,Eisenberg T,Madeo F,Falcone C

更新日期：2005-11-01 00:00:00

abstract：:The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...

journal_title：EMBO reports

authors： Ahuja M,Muallem S

更新日期：2014-03-01 00:00:00

abstract：:The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library of chromatin regulators. We identified genes involved in chromatin remodeling, sister ch...

journal_title：EMBO reports

authors： Warmerdam DO,Alonso-de Vega I,Wiegant WW,van den Broek B,Rother MB,Wolthuis RM,Freire R,van Attikum H,Medema RH,Smits VA

更新日期：2020-01-07 00:00:00

abstract：:Zika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by w...

journal_title：EMBO reports

authors： Tiwari SK,Dang JW,Lin N,Qin Y,Wang S,Rana TM

更新日期：2020-10-19 00:00:00

abstract：:Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol 3,5-bisphosphate. ...

journal_title：EMBO reports

authors： Jefferies HB,Cooke FT,Jat P,Boucheron C,Koizumi T,Hayakawa M,Kaizawa H,Ohishi T,Workman P,Waterfield MD,Parker PJ

更新日期：2008-02-01 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In a...

journal_title：EMBO reports

authors： Colombo R,Boggio R,Seiser C,Draetta GF,Chiocca S

更新日期：2002-11-01 00:00:00

abstract：:We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted beta-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induce...

journal_title：EMBO reports

authors： van de Wetering M,Oving I,Muncan V,Pon Fong MT,Brantjes H,van Leenen D,Holstege FC,Brummelkamp TR,Agami R,Clevers H

更新日期：2003-06-01 00:00:00

abstract：:Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication init...

journal_title：EMBO reports

authors： Datta A,Ghatak D,Das S,Banerjee T,Paul A,Butti R,Gorain M,Ghuwalewala S,Roychowdhury A,Alam SK,Das P,Chatterjee R,Dasgupta M,Panda CK,Kundu GC,Roychoudhury S

更新日期：2017-11-01 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase (LCK) and FYN oncogene related to SRC, FGR, YES (FYN) mediate GC-induced inhibition of T-cell-receptor (TCR) signalling. Her...

journal_title：EMBO reports

authors： Löwenberg M,Verhaar AP,Bilderbeek J,Marle Jv,Buttgereit F,Peppelenbosch MP,van Deventer SJ,Hommes DW

更新日期：2006-10-01 00:00:00

abstract：:Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome-dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of autophagosomes and lys...

journal_title：EMBO reports

authors： Wang Y,Huang Y,Liu J,Zhang J,Xu M,You Z,Peng C,Gong Z,Liu W

更新日期：2020-01-07 00:00:00

abstract：:BAT-controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet-induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essent...

journal_title：EMBO reports

authors： Mahdaviani K,Benador IY,Su S,Gharakhanian RA,Stiles L,Trudeau KM,Cardamone M,Enríquez-Zarralanga V,Ritou E,Aprahamian T,Oliveira MF,Corkey BE,Perissi V,Liesa M,Shirihai OS

更新日期：2017-07-01 00:00:00

abstract：:Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin can itself be phosphorylated at nearly every serine, threonine, and tyrosine residue. However, the effect of this modification on ubiquitin function is largely unknown....

journal_title：EMBO reports

authors： Swaney DL,Rodríguez-Mias RA,Villén J

更新日期：2015-09-01 00:00:00

abstract：:Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi-protein complex is activated by supernumerary centrosomes to induce p53 and restrict proliferation of polyplo...

journal_title：EMBO reports

authors： Sladky VC,Knapp K,Szabo TG,Braun VZ,Bongiovanni L,van den Bos H,Spierings DC,Westendorp B,Curinha A,Stojakovic T,Scharnagl H,Timelthaler G,Tsuchia K,Pinter M,Semmler G,Foijer F,de Bruin A,Reiberger T,Rohr-Udilova N,

更新日期：2020-11-23 00:00:00

abstract：:Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigen...

journal_title：EMBO reports

authors： Augert A,Payré C,de Launoit Y,Gil J,Lambeau G,Bernard D

更新日期：2009-03-01 00:00:00

abstract：:Research into the extreme feats of endurance that humans and some animals achieve has uncovered a range of metabolic and physiological adaptations along with their evolutionary origins. ...

journal_title：EMBO reports

authors： Hunter P

更新日期：2019-11-05 00:00:00

abstract：:Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...

journal_title：EMBO reports

authors： Guo J,Polymenis M

更新日期：2006-11-01 00:00:00

abstract：:Sepsis, or blood poisoning, is a savage response of the body to infection. It can lead to organ failure, blood pressure decline, heart failure, and coma. Between 20 and 30 million people suffer from sepsis each year, leading to 8 million deaths. Although certain people are more at risk than others (young children, eld...

journal_title：EMBO reports

authors： Van Looveren K,Van Wyngene L,Libert C

更新日期：2020-01-07 00:00:00

abstract：:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, p...

journal_title：EMBO reports

authors： Sriram A,Bohlen J,Teleman AA

更新日期：2018-10-01 00:00:00

abstract：:Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of re...

journal_title：EMBO reports

authors： Lefebvre B,Ozato K,Lefebvre P

更新日期：2002-04-01 00:00:00

abstract：:Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...

journal_title：EMBO reports

authors： Yan WW,Liang YL,Zhang QX,Wang D,Lei MZ,Qu J,He XH,Lei QY,Wang YP

更新日期：2018-12-01 00:00:00

abstract：:Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

journal_title：EMBO reports

authors： Fernandez-Capetillo O

更新日期：2010-01-01 00:00:00

abstract：:Microbes exert a major impact on human health and disease by either promoting or disrupting homeostasis, in the latter instance leading to the development of infectious diseases. Such disparate outcomes are driven by the ever-evolving genetic diversity of microbes and the countervailing host responses that minimize th...

journal_title：EMBO reports

authors： Soares MP,Weiss G

更新日期：2015-11-01 00:00:00

abstract：:Yeast species have undergone extensive genome reorganization in their evolutionary history, including variations in chromosome number and large chromosomal rearrangements, such as translocations. To determine directly the contribution of chromosomal translocations to the whole organism's fitness, we devised a strategy...

journal_title：EMBO reports

authors： Colson I,Delneri D,Oliver SG

更新日期：2004-04-01 00:00:00