Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.

abstract：:The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate...

journal_title：EMBO reports

authors： Ady V,Perroy J,Tricoire L,Piochon C,Dadak S,Chen X,Dusart I,Fagni L,Lambolez B,Levenes C

更新日期：2014-01-01 00:00:00

abstract：:The aggregation of the two yeast proteins Sup35p and Ure2p is widely accepted as a model for explaining the prion propagation of the phenotypes [PSI+] and [URE3], respectively. Here, we demonstrate that the propagation of [URE3] cannot simply be the consequence of generating large aggregates of Ure2p, because such agg...

journal_title：EMBO reports

authors： Fernandez-Bellot E,Guillemet E,Ness F,Baudin-Baillieu A,Ripaud L,Tuite M,Cullin C

更新日期：2002-01-01 00:00:00

abstract：:Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1S616 phosphorylation is significantly reduced in cells and mouse tissues deficient for PINK1, ...

journal_title：EMBO reports

authors： Han H,Tan J,Wang R,Wan H,He Y,Yan X,Guo J,Gao Q,Li J,Shang S,Chen F,Tian R,Liu W,Liao L,Tang B,Zhang Z

更新日期：2020-08-05 00:00:00

abstract：:The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...

journal_title：EMBO reports

authors： Mak DO,Pearson JE,Loong KP,Datta S,Fernández-Mongil M,Foskett JK

更新日期：2007-11-01 00:00:00

abstract：:Caspase-3 is a crucial component of the apoptotic machinery in many cell types. Here, we report the timescale of caspase-3 activation in single living cells undergoing apoptosis. This was achieved by measuring the extent of fluorescence resonance energy transfer within a recombinant substrate containing cyan fluoresce...

journal_title：EMBO reports

authors： Tyas L,Brophy VA,Pope A,Rivett AJ,Tavaré JM

更新日期：2000-09-01 00:00:00

abstract：:Reading the academic literature is an essential part of a scientist's job. David Smith argues that reading fiction can be even more important for creativity and productivity than papers and reviews. ...

journal_title：EMBO reports

authors： Smith DR

更新日期：2021-01-04 00:00:00

abstract：:The function of protein phosphatase 1 nuclear-targeting subunit (PNUTS)--one of the most abundant nuclear-targeting subunits of protein phosphatase 1 (PP1c)--remains largely uncharacterized. We show that PNUTS depletion by small interfering RNA activates a G2 checkpoint in unperturbed cells and prolongs G2 checkpoint ...

journal_title：EMBO reports

authors： Landsverk HB,Mora-Bermúdez F,Landsverk OJ,Hasvold G,Naderi S,Bakke O,Ellenberg J,Collas P,Syljuåsen RG,Küntziger T

更新日期：2010-11-01 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:Retinoic acid (RA) signalling ensures that vertebrate mesoderm segmentation is bilaterally synchronized, and corrects transient interferences from asymmetric left-right (L-R) signals involved in organ lateralization. Snail genes participate in both these processes and, although they are expressed symmetrically in the ...

journal_title：EMBO reports

authors： Morales AV,Acloque H,Ocaña OH,de Frutos CA,Gold V,Nieto MA

更新日期：2007-01-01 00:00:00

abstract：:Dynactin has been proposed to link the microtubule-associated motor cytoplasmic dynein with membranous cargo; however, the mechanism by which dynactin-membrane interaction is regulated is unknown. Here we show that dynein and dynactin exist in discrete cytosolic and membrane-bound states in the filamentous fungus Neur...

journal_title：EMBO reports

authors： Kumar S,Zhou Y,Plamann M

更新日期：2001-10-01 00:00:00

abstract：:The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism a...

journal_title：EMBO reports

authors： Cappellen D,Schlange T,Bauer M,Maurer F,Hynes NE

更新日期：2007-01-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically linked and if a gain o...

journal_title：EMBO reports

authors： Werner G,Damme M,Schludi M,Gnörich J,Wind K,Fellerer K,Wefers B,Wurst W,Edbauer D,Brendel M,Haass C,Capell A

更新日期：2020-10-05 00:00:00

abstract：:Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP activity, inducing grow...

journal_title：EMBO reports

authors： Ito Y,Oinuma I,Katoh H,Kaibuchi K,Negishi M

更新日期：2006-07-01 00:00:00

abstract：:The EMBO conference 'From Structure to Function of Translocation Machines' took place in April 2013 in Dubrovnik, Croatia. The meeting brought together a mix of established and aspiring researchers to discuss a wealth of unpublished data and ideas in a lively scientific programme of talks designed to shatter the estab...

journal_title：EMBO reports

authors： Lithgow T,Waksman G

更新日期：2013-07-01 00:00:00

abstract：:Individuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3'-5' DNA helicase, and is a member...

journal_title：EMBO reports

authors： Constantinou A,Tarsounas M,Karow JK,Brosh RM,Bohr VA,Hickson ID,West SC

更新日期：2000-07-01 00:00:00

abstract：:Mammalian artificial chromosomes (MACs) provide a new tool for the improvement of our knowledge of chromosome structure and function. Moreover, they constitute an alternative and potentially powerful tool for gene delivery both in cultured cells and for the production of transgenic animals. In the present work we desc...

journal_title：EMBO reports

authors： Auriche C,Donini P,Ascenzioni F

更新日期：2001-02-01 00:00:00

abstract：:The COVID-19 crisis has further highlighted the challenges for open science and data sharing in biomedical research and the need for more traceability and transparency. ...

journal_title：EMBO reports

authors： Minari J,Yoshizawa G,Shinomiya N

更新日期：2020-11-05 00:00:00

abstract：:The cytoplasm is the main place for protein translation from where nascent proteins are transported to their working areas, including the inside, outside, and membrane of the cell. The majority of newly synthesized membrane proteins is co-translationally inserted into the membrane by the evolutionary conserved Sec tra...

journal_title：EMBO reports

authors： Tanaka Y,Tsukazaki T

更新日期：2019-10-04 00:00:00

abstract：:The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto-inhibition. However, the molecular mechanism underlying Nedd4 E3 auto-inhibition and activation is poorly un...

journal_title：EMBO reports

authors： Zhu K,Shan Z,Chen X,Cai Y,Cui L,Yao W,Wang Z,Shi P,Tian C,Lou J,Xie Y,Wen W

更新日期：2017-09-01 00:00:00

abstract：:Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that N...

journal_title：EMBO reports

authors： Sundqvist A,Liu G,Mirsaliotis A,Xirodimas DP

更新日期：2009-10-01 00:00:00

abstract：:Mini-chromosome maintenance (MCM) proteins form a conserved family found in all eukaryotes and are essential for DNA replication. They exist as heteromultimeric complexes containing as many as six different proteins. These complexes are believed to be the replicative helicases, functioning as hexameric rings at replic...

journal_title：EMBO reports

authors： Yu X,VanLoock MS,Poplawski A,Kelman Z,Xiang T,Tye BK,Egelman EH

更新日期：2002-08-01 00:00:00

abstract：:The COP9 signalosome (CSN) is a highly conserved protein complex that was originally described as a repressor of light-dependent growth and transcription in Arabidopsis. The most studied CSN function is the regulation of protein degradation, which occurs primarily through the removal of the ubiquitin-like modifier Ned...

journal_title：EMBO reports

authors： Chamovitz DA

更新日期：2009-04-01 00:00:00

abstract：:The bacterium Bacillus subtilis produces the DNA integrity scanning protein (DisA), a checkpoint protein that delays sporulation in response to DNA damage. DisA scans the chromosome and pauses at sites of DNA lesions. Structural analysis showed that DisA synthesizes the small molecule cyclic diadenosine monophosphate ...

journal_title：EMBO reports

authors： Oppenheimer-Shaanan Y,Wexselblatt E,Katzhendler J,Yavin E,Ben-Yehuda S

更新日期：2011-06-01 00:00:00

abstract：:Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5/Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5-null mouse em...

journal_title：EMBO reports

authors： Poncet N,Halley PA,Lipina C,Gierliński M,Dady A,Singer GA,Febrer M,Shi YB,Yamaguchi TP,Taylor PM,Storey KG

更新日期：2020-01-07 00:00:00

abstract：:The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...

journal_title：EMBO reports

authors： Ernst HA,Olsen AN,Larsen S,Lo Leggio L

更新日期：2004-03-01 00:00:00

abstract：:The mitochondrial matrix protease CLPP plays a central role in the activation of the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans Far less is known about mammalian UPR(mt) signaling, although similar roles were assumed for central players, including CLPP To better understand the mammalia...

journal_title：EMBO reports

authors： Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A

更新日期：2016-07-01 00:00:00

abstract：:It has been suggested that DNA methylation/demethylation is involved in regulating V(D)J rearrangement. Although methylated DNA is thought to induce an inaccessible chromatin structure, it is unclear whether DNA methylation can directly control V(D)J recombination independently of chromatin structure. In this study, w...

journal_title：EMBO reports

authors： Nakase H,Takahama Y,Akamatsu Y

更新日期：2003-08-01 00:00:00

abstract：:Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

journal_title：EMBO reports

authors： Fernandez-Capetillo O

更新日期：2010-01-01 00:00:00

abstract：:TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For exampl...

journal_title：EMBO reports

authors： Durán RV,Hall MN

更新日期：2012-02-01 00:00:00

abstract：:The major DNA methyltransferase, Dnmt1, associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand. In view of the slow kinetics of Dnmt1 in vitro versus the fast progression of the replication fork, we have tested whether Dnmt1 associates with chromatin beyond...

journal_title：EMBO reports

authors： Easwaran HP,Schermelleh L,Leonhardt H,Cardoso MC

更新日期：2004-12-01 00:00:00