Regulation of nucleolar signalling to p53 through NEDDylation of L11.

abstract：:Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newl...

journal_title：EMBO reports

authors： Camara JE,Breier AM,Brendler T,Austin S,Cozzarelli NR,Crooke E

更新日期：2005-08-01 00:00:00

abstract：:The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt...

journal_title：EMBO reports

authors： Mendes CS,Arama E,Brown S,Scherr H,Srivastava M,Bergmann A,Steller H,Mollereau B

更新日期：2006-09-01 00:00:00

abstract：:Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, eac...

journal_title：EMBO reports

authors： Klosowiak JL,Focia PJ,Chakravarthy S,Landahl EC,Freymann DM,Rice SE

更新日期：2013-11-01 00:00:00

abstract：:Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-p...

journal_title：EMBO reports

authors： Hwang G,Kim S,Cho JY,Paik I,Kim JI,Oh E

更新日期：2019-10-04 00:00:00

abstract：:The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondr...

journal_title：EMBO reports

authors： Braschi E,Zunino R,McBride HM

更新日期：2009-07-01 00:00:00

abstract：:While the genome sequence and gene content are available for an increasing number of organisms, eukaryotic selenoproteins remain poorly characterized. The dual role of the UGA codon confounds the identification of novel selenoprotein genes. Here, we describe a comparative genomics approach that relies on the genome-wi...

journal_title：EMBO reports

authors： Castellano S,Novoselov SV,Kryukov GV,Lescure A,Blanco E,Krol A,Gladyshev VN,Guigó R

更新日期：2004-01-01 00:00:00

abstract：:Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and biochemical studies using a variety of different model systems have led to the discovery of 23 PEX genes required for this process. Although it is generally believed that, in contrast to mitochondria and chloroplasts, translocati...

journal_title：EMBO reports

authors： Einwächter H,Sowinski S,Kunau WH,Schliebs W

更新日期：2001-11-01 00:00:00

abstract：:Very little is known about the biogenesis and assembly of oligomeric membrane proteins. In this study, the biogenesis of KcsA, a prokaryotic homotetrameric potassium channel, is investigated. Using in vivo pulse-chase experiments, both the monomeric and tetrameric form could be identified. The conversion of monomers i...

journal_title：EMBO reports

authors： van Dalen A,Schrempf H,Killian JA,de Kruijff B

更新日期：2000-10-01 00:00:00

abstract：:DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...

journal_title：EMBO reports

authors： Arias-Lopez C,Lazaro-Trueba I,Kerr P,Lord CJ,Dexter T,Iravani M,Ashworth A,Silva A

更新日期：2006-02-01 00:00:00

abstract：:Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000-4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. T...

journal_title：EMBO reports

authors： Capelson M,Hetzer MW

更新日期：2009-07-01 00:00:00

abstract：:Ligands for nuclear receptors facilitate the exchange of co-repressors for coactivators, leading to chromatin modifications that favour the activation of gene transcription. Here, we show that the repressed state of an endogenous retinoic acid-regulated gene is quickly re-established after ligand removal. As expected,...

journal_title：EMBO reports

authors： Hartman HB,Yu J,Alenghat T,Ishizuka T,Lazar MA

更新日期：2005-05-01 00:00:00

abstract：:The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated a significant number of clones in the public databases, as a result of the use of the transposon in bacterial cloning st...

journal_title：EMBO reports

authors： Hill F,Gemünd C,Benes V,Ansorge W,Gibson TJ

更新日期：2000-07-01 00:00:00

abstract：:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

journal_title：EMBO reports

authors： Smythe E,Ayscough KR

更新日期：2003-03-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:The Polycomb group (PcG) of proteins conveys epigenetic inheritance of repressed transcriptional states. In Drosophila, the Polycomb repressive complex 1 (PRC1) maintains the silent state by inhibiting the transcription machinery and chromatin remodelling at core promoters. Using immunoprecipitation of in vivo formald...

journal_title：EMBO reports

authors： Breiling A,O'Neill LP,D'Eliseo D,Turner BM,Orlando V

更新日期：2004-10-01 00:00:00

abstract：:Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative cap...

journal_title：EMBO reports

authors： Fernandez-Capetillo O

更新日期：2010-01-01 00:00:00

abstract：:The discovery that adult somatic cells can be reprogrammed into pluripotent cells by expressing a combination of factors associated with pluripotency holds immense promise for a wide range of biotechnological and therapeutic applications. However, some hurdles-such as improving the low reprogramming efficiencies and e...

journal_title：EMBO reports

authors： Banito A,Gil J

更新日期：2010-05-01 00:00:00

abstract：:Immune signaling networks must be tunable to alleviate fitness costs associated with immunity and, at the same time, robust against pathogen interferences. How these properties mechanistically emerge in plant immune signaling networks is poorly understood. Here, we discovered a molecular mechanism by which the model p...

journal_title：EMBO reports

authors： Mine A,Nobori T,Salazar-Rondon MC,Winkelmüller TM,Anver S,Becker D,Tsuda K

更新日期：2017-03-01 00:00:00

abstract：:Proteins of the Imp4/Brix superfamily are involved in ribosomal RNA processing, an essential function in all cells. We report the first structure of an Imp4/Brix superfamily protein, the Mil (for Methanothermobacter thermautotrophicus Imp4-like) protein (gene product Mth680), from the archaeon M. thermautotrophicus. T...

journal_title：EMBO reports

authors： Ng CL,Waterman D,Koonin EV,Antson AA,Ortiz-Lombardía M

更新日期：2005-02-01 00:00:00

abstract：:Endo180, also known as the urokinase plasminogen activator receptor (uPAR)-associated protein (uPARAP), is one of the four members of the mannose receptor family, and is implicated in extracellular-matrix remodelling through its interactions with collagens, sugars and uPAR. The extracellular portion of Endo180 contain...

journal_title：EMBO reports

authors： Rivera-Calzada A,Robertson D,MacFadyen JR,Boskovic J,Isacke CM,Llorca O

更新日期：2003-08-01 00:00:00

abstract：:Pair-rule genes in Drosophila integrate the positional information provided by the transcription factor gradients of gap genes and set the framework for the expression of the segment polarity genes. Pair-rule genes are also expressed during the segmentation of the short germ-band embryo of the flour beetle Tribolium, ...

journal_title：EMBO reports

authors： Eckert C,Aranda M,Wolff C,Tautz D

更新日期：2004-06-01 00:00:00

abstract：:Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin can itself be phosphorylated at nearly every serine, threonine, and tyrosine residue. However, the effect of this modification on ubiquitin function is largely unknown....

journal_title：EMBO reports

authors： Swaney DL,Rodríguez-Mias RA,Villén J

更新日期：2015-09-01 00:00:00

abstract：:Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs interact with the ALTERNATIVE SPLICING COMPETITOR (ASCO) lncRNA. Here, we analyze the effect of ...

journal_title：EMBO reports

authors： Rigo R,Bazin J,Romero-Barrios N,Moison M,Lucero L,Christ A,Benhamed M,Blein T,Huguet S,Charon C,Crespi M,Ariel F

更新日期：2020-05-06 00:00:00

abstract：:Global climate change and the increasing human population require crop varieties with higher yield and draught resistance. But meeting both goals is not an easy task for breeders and plant science. ...

journal_title：EMBO reports

authors： Moshelion M

更新日期：2020-11-29 00:00:00

abstract：:The function of protein phosphatase 1 nuclear-targeting subunit (PNUTS)--one of the most abundant nuclear-targeting subunits of protein phosphatase 1 (PP1c)--remains largely uncharacterized. We show that PNUTS depletion by small interfering RNA activates a G2 checkpoint in unperturbed cells and prolongs G2 checkpoint ...

journal_title：EMBO reports

authors： Landsverk HB,Mora-Bermúdez F,Landsverk OJ,Hasvold G,Naderi S,Bakke O,Ellenberg J,Collas P,Syljuåsen RG,Küntziger T

更新日期：2010-11-01 00:00:00

abstract：:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, p...

journal_title：EMBO reports

authors： Sriram A,Bohlen J,Teleman AA

更新日期：2018-10-01 00:00:00

abstract：:Recruitment of beta-arrestin (beta-arr) to agonist-stimulated G-protein-coupled receptors (GPCRs) has a crucial role in controlling signalling efficacy and selectivity. When translocated to the receptor, beta-arr is believed to undergo important conformational rearrangement necessary for its downstream actions. To pro...

journal_title：EMBO reports

authors： Charest PG,Terrillon S,Bouvier M

更新日期：2005-04-01 00:00:00

abstract：:Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5/Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5-null mouse em...

journal_title：EMBO reports

authors： Poncet N,Halley PA,Lipina C,Gierliński M,Dady A,Singer GA,Febrer M,Shi YB,Yamaguchi TP,Taylor PM,Storey KG

更新日期：2020-01-07 00:00:00

abstract：:Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis may be critical for controlling diverse biological processes includin...

journal_title：EMBO reports

authors： De Gassart A,Demaria O,Panes R,Zaffalon L,Ryazanov AG,Gilliet M,Martinon F

更新日期：2016-10-01 00:00:00

abstract：:The delta2 glutamate receptor (GluRdelta2) has a crucial role in cerebellar functions; disruption of GluRdelta2 alleles in mice (delta2(-/-)) impairs synapse formation and long-term depression, which is thought to underlie motor learning in the cerebellum, and consequently leads to motor discoordination. However, it h...

journal_title：EMBO reports

authors： Hirai H,Miyazaki T,Kakegawa W,Matsuda S,Mishina M,Watanabe M,Yuzaki M

更新日期：2005-01-01 00:00:00