Abstract:
:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, proteotoxic stress, or genotoxic stress. Since cancer cells are often exposed to these stresses, they rely on alternate modes of translation initiation for protein synthesis and cell growth. Cancer mutations are now being identified in components of the translation machinery and in cis-regulatory elements of mRNAs, which both control translation of cancer-relevant genes. In this review, we provide an overview on the various modes of non-canonical translation initiation, such as leaky scanning, translation re-initiation, ribosome shunting, IRES-dependent translation, and m6A-dependent translation, and then discuss the influence of stress on these different modes of translation. Finally, we present examples of how these modes of translation are dysregulated in cancer cells, allowing them to grow, to proliferate, and to survive, thereby highlighting the importance of translational control in cancer.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Sriram A,Bohlen J,Teleman AAdoi
10.15252/embr.201845947subject
Has Abstractpub_date
2018-10-01 00:00:00issue
10eissn
1469-221Xissn
1469-3178pii
embr.201845947journal_volume
19pub_type
杂志文章,评审相关文献
EMBO REPORTS文献大全abstract::Intercellular communication orchestrates effective immune responses against disease-causing agents. Extracellular vesicles (EVs) are potent mediators of cell-cell communication. EVs carry bioactive molecules, including microRNAs, which modulate gene expression and function in the recipient cell. Here, we show that for...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948925
更新日期:2020-04-03 00:00:00
abstract::The first EMBO Conference on Experimental Approaches to Evolution and Ecology in Yeast was held in Heidelberg, Germany, at the end of September 2010. What might sound like a rather narrow topic actually covered a broad range of interests, approaches, and systems and generated a great deal of excitement among participa...
journal_title:EMBO reports
pub_type:
doi:10.1038/embor.2010.204
更新日期:2011-01-01 00:00:00
abstract::The COP9 signalosome (CSN) is a highly conserved protein complex that was originally described as a repressor of light-dependent growth and transcription in Arabidopsis. The most studied CSN function is the regulation of protein degradation, which occurs primarily through the removal of the ubiquitin-like modifier Ned...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.33
更新日期:2009-04-01 00:00:00
abstract::Streptococcus pneumoniae causes more than one million deaths every year, mostly of young children in developing countries, due to pneumonia, bacteremia and meningitis. The emergence and dissemination of drug-resistant pneumococcal strains, coupled to changing patterns of virulence and the inadequacy of available vacci...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kvf152
更新日期:2002-08-01 00:00:00
abstract::Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studi...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.15252/embr.201744816
更新日期:2017-12-01 00:00:00
abstract::WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201744632
更新日期:2018-02-01 00:00:00
abstract::Research into the extreme feats of endurance that humans and some animals achieve has uncovered a range of metabolic and physiological adaptations along with their evolutionary origins. ...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.15252/embr.201949396
更新日期:2019-11-05 00:00:00
abstract::The cytosolic pathogen sensor RIG-I is activated by RNAs with exposed 5'-triphosphate (5'-ppp) and terminal double-stranded structures, such as those that are generated during viral infection. RIG-I has been shown to translocate on dsRNA in an ATP-dependent manner. However, the precise role of the ATPase activity in R...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2013.102
更新日期:2013-09-01 00:00:00
abstract::Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we provide a first proof of concept for such a ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948269
更新日期:2019-08-01 00:00:00
abstract::RNA editing in plant organelles is mediated by site-specific, nuclear-encoded factors. Previous data suggested that the maintenance of these factors depends on the presence of their rapidly evolving cognate sites. The surprising ability of allotetraploid Nicotiana tabacum (tobacco) to edit a foreign site in the chloro...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400619
更新日期:2006-03-01 00:00:00
abstract::The tumour suppressor ARF (alternative reading frame), which is mutated or silenced in various tumours, has a crucial role in tumour surveillance to suppress unwarranted cell growth and proliferation. ARF has also been linked to the DNA-damage-induced response of p53 because of its ability to inhibit murine double min...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.139
更新日期:2009-09-01 00:00:00
abstract::WHITE COLLAR-1 (WC-1) is the limiting component of the White Collar Complex (WCC) controlling expression of the Neurospora circadian clock protein Frequency (FRQ). Accumulation of WC-1 is supported by FRQ on a post-transcriptional level. Here, we show that transcription of wc-1 is organized in a complex way. Three pro...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400595
更新日期:2006-02-01 00:00:00
abstract::Mammalian artificial chromosomes (MACs) provide a new tool for the improvement of our knowledge of chromosome structure and function. Moreover, they constitute an alternative and potentially powerful tool for gene delivery both in cultured cells and for the production of transgenic animals. In the present work we desc...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kve018
更新日期:2001-02-01 00:00:00
abstract::Adult tissue maintenance is often dependent on resident stem cells; however, the phenotypic and functional heterogeneity existing within this self-renewing population is poorly understood. Here, we define distinct subsets of undifferentiated spermatogonia (spermatogonial progenitor cells; SPCs) by differential respons...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201439379
更新日期:2015-04-01 00:00:00
abstract::The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (DeltaN-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length p53. Here, we s...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400623
更新日期:2006-04-01 00:00:00
abstract::Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples ch...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/sj.embor.7400337
更新日期:2005-02-01 00:00:00
abstract::STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250 partners of STK38 and find that STK38 modulates its partnership depending on the cellular context by increa...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948150
更新日期:2019-11-05 00:00:00
abstract::The influence of circadian rhythms on memory has long been studied; however, the molecular prerequisites for their interaction remain elusive. The hippocampus, which is a region of the brain important for long-term memory formation and temporary maintenance, shows circadian rhythmicity in pathways central to the memor...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.123
更新日期:2009-06-01 00:00:00
abstract::Yeast species have undergone extensive genome reorganization in their evolutionary history, including variations in chromosome number and large chromosomal rearrangements, such as translocations. To determine directly the contribution of chromosomal translocations to the whole organism's fitness, we devised a strategy...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400123
更新日期:2004-04-01 00:00:00
abstract::We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means of a P-element insertional genetic screen. Helicase89B belongs to the Mot1p/BTAF1 subfamily of SNF2-like ATPases. This subfamily can interact with TATA-binding proteins, but whethe...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400542
更新日期:2005-11-01 00:00:00
abstract::In Saccharomyces cerevisiae, genome stability depends on RNases H1 and H2, which remove ribonucleotides from DNA and eliminate RNA-DNA hybrids (R-loops). In Schizosaccharomyces pombe, RNase H enzymes were reported to process RNA-DNA hybrids produced at a double-strand break (DSB) generated by I-PpoI meganuclease. Howe...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201745335
更新日期:2018-05-01 00:00:00
abstract::Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newl...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400467
更新日期:2005-08-01 00:00:00
abstract::β-arrestin 1 and 2 (also known as arrestin 2 and 3) are homologous adaptor proteins that regulate seven-transmembrane receptor trafficking and signalling. Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulatio...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2012.187
更新日期:2013-02-01 00:00:00
abstract::The discovery that adult somatic cells can be reprogrammed into pluripotent cells by expressing a combination of factors associated with pluripotency holds immense promise for a wide range of biotechnological and therapeutic applications. However, some hurdles-such as improving the low reprogramming efficiencies and e...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2010.47
更新日期:2010-05-01 00:00:00
abstract::The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400093
更新日期:2004-03-01 00:00:00
abstract::Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms resi...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201947832
更新日期:2020-03-04 00:00:00
abstract::The Drosophila immune system is able to discriminate between classes of bacteria. Detection of Gram-positive bacteria involves a complex of two pattern recognition receptors: peptidoglycan recognition protein SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1). These activate the Toll signalling pathway. To defin...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400371
更新日期:2005-04-01 00:00:00
abstract::The final irreversible step in the duplication and distribution of genomes to daughter cells takes place at the metaphase to anaphase transition. At this point aligned sister chromatid pairs split and separate. During metaphase, cohesion between sister chromatids is maintained by the chromosomal multi-subunit cohesin ...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kve113
更新日期:2001-06-01 00:00:00
abstract::The eukaryotic GINS complex has an essential role in the initiation and elongation phases of genome duplication. It is composed of four paralogous subunits--Sld5, Psf1, Psf2 and Psf3--which are ubiquitous and evolutionarily conserved in eukaryotic organisms. Here, we report the biochemical characterization of the huma...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400870
更新日期:2007-01-01 00:00:00
abstract::Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation and for assembling fully functional kinetochores. Here, we used vertebrate cells conditionally ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400077
更新日期:2004-02-01 00:00:00