Structure of the conserved domain of ANAC, a member of the NAC family of transcription factors.

abstract：:Processive motor proteins are stochastic steppers that perform actual mechanical steps for only a minor fraction of the time they are bound to the filament track. Motors usually work in teams and therefore the question arises whether the stochasticity of stepping can cause mutual interference when motors are mechanica...

journal_title：EMBO reports

authors： Bieling P,Telley IA,Piehler J,Surrey T

更新日期：2008-11-01 00:00:00

abstract：:Metazoans use protein homeostasis (proteostasis) pathways to respond to adverse physiological conditions, changing environment, and aging. The nervous system regulates proteostasis in different tissues, but the mechanism is not understood. Here, we show that Caenorhabditis elegans employs biogenic amine neurotransmitt...

journal_title：EMBO reports

authors： Joshi KK,Matlack TL,Pyonteck S,Vora M,Menzel R,Rongo C

更新日期：2021-01-20 00:00:00

abstract：:The tumor suppressor Smad4, a key mediator of the TGF-β/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen-activated protein kinase (MAPK) plays a pivotal role in regulating its transcriptional activity and stability. In contrast, r...

journal_title：EMBO reports

authors： Park DS,Yoon GH,Kim EY,Lee T,Kim K,Lee PC,Chang EJ,Choi SC

更新日期：2020-05-06 00:00:00

abstract：:Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...

journal_title：EMBO reports

authors： Munier AI,Doucet D,Perrodou E,Zachary D,Meister M,Hoffmann JA,Janeway CA Jr,Lagueux M

更新日期：2002-12-01 00:00:00

abstract：:The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...

journal_title：EMBO reports

authors： Mak DO,Pearson JE,Loong KP,Datta S,Fernández-Mongil M,Foskett JK

更新日期：2007-11-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:The histone H3 N-terminal protein domain (N-tail) is regulated by multiple posttranslational modifications, including methylation, acetylation, phosphorylation, and by proteolytic cleavage. However, the mechanism underlying H3 N-tail proteolytic cleavage is largely elusive. Here, we report that JMJD5, a Jumonji C (Jmj...

journal_title：EMBO reports

authors： Shen J,Xiang X,Chen L,Wang H,Wu L,Sun Y,Ma L,Gu X,Liu H,Wang L,Yu YN,Shao J,Huang C,Chin YE

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) originate from stemloop-forming precursor RNAs found in longer primary transcripts that often contain introns. We show that in plants, those introns, when located 3' of the stemloop, can promote mature miRNA accumulation, through a mechanism that likely operates at the level of miRNA processing or s...

journal_title：EMBO reports

authors： Schwab R,Speth C,Laubinger S,Voinnet O

更新日期：2013-07-01 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the primary cause of symptomatic urinary tract infection. The P-pili, a bacterial surface organelle, mediates the bacterial host--cell adhesion. The PapG adhesin has generated much interest in recent years, not only because of its clinical value, i.e. in the prevention of micro...

journal_title：EMBO reports

authors： Sung MA,Fleming K,Chen HA,Matthews S

更新日期：2001-07-01 00:00:00

abstract：:The discovery that adult somatic cells can be reprogrammed into pluripotent cells by expressing a combination of factors associated with pluripotency holds immense promise for a wide range of biotechnological and therapeutic applications. However, some hurdles-such as improving the low reprogramming efficiencies and e...

journal_title：EMBO reports

authors： Banito A,Gil J

更新日期：2010-05-01 00:00:00

abstract：:Mitochondria play a central role in stem cell homeostasis. Reversible switching between aerobic and anaerobic metabolism is critical for stem cell quiescence, multipotency, and differentiation, as well as for cell reprogramming. However, the effect of mitochondrial dysfunction on neural stem cell (NSC) function is uns...

journal_title：EMBO reports

authors： Díaz-Castro B,Pardal R,García-Flores P,Sobrino V,Durán R,Piruat JI,López-Barneo J

更新日期：2015-11-01 00:00:00

abstract：:Howy Jacobs reminisces about his many editorials and asks whether they have ever been read by anyone. ...

journal_title：EMBO reports

authors： Jacobs H

更新日期：2020-07-03 00:00:00

abstract：:The COP9 signalosome (CSN) is a highly conserved protein complex that was originally described as a repressor of light-dependent growth and transcription in Arabidopsis. The most studied CSN function is the regulation of protein degradation, which occurs primarily through the removal of the ubiquitin-like modifier Ned...

journal_title：EMBO reports

authors： Chamovitz DA

更新日期：2009-04-01 00:00:00

abstract：:Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1S616 phosphorylation is significantly reduced in cells and mouse tissues deficient for PINK1, ...

journal_title：EMBO reports

authors： Han H,Tan J,Wang R,Wan H,He Y,Yan X,Guo J,Gao Q,Li J,Shang S,Chen F,Tian R,Liu W,Liao L,Tang B,Zhang Z

更新日期：2020-08-05 00:00:00

abstract：:A-kinase (or PKA)-anchoring protein AKAP95 is a zinc-finger protein implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. We have identified determinants of chromatin-binding, condensin-targeting and chromosome-condensation activities of AKAP95. Binding of AKAP95 to...

journal_title：EMBO reports

authors： Eide T,Carlson C,Taskén KA,Hirano T,Taskén K,Collas P

更新日期：2002-05-01 00:00:00

abstract：:Mini-chromosome maintenance (MCM) proteins form a conserved family found in all eukaryotes and are essential for DNA replication. They exist as heteromultimeric complexes containing as many as six different proteins. These complexes are believed to be the replicative helicases, functioning as hexameric rings at replic...

journal_title：EMBO reports

authors： Yu X,VanLoock MS,Poplawski A,Kelman Z,Xiang T,Tye BK,Egelman EH

更新日期：2002-08-01 00:00:00

abstract：:The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling. In this study, phenotype analysis of knockin/knockout Lgr5-eGFP-IRES-Cre and Lgr5-DTReGFP embryos reveals that Lgr5 deficiency during Wnt-mediated cytodifferentiation results in amplification of ISCs and early differe...

journal_title：EMBO reports

authors： Fernandez Vallone V,Leprovots M,Ribatallada-Soriano D,Gerbier R,Lefort A,Libert F,Vassart G,Garcia MI

更新日期：2020-07-03 00:00:00

abstract：:The high-resolution spatial induction of ultraviolet (UV) photoproducts in mammalian cellular DNA is a goal of many scientists who study UV damage and repair. Here we describe how UV photoproducts can be induced in cellular DNA within nanometre dimensions by near-diffraction-limited 750 nm infrared laser radiation. Th...

journal_title：EMBO reports

authors： Meldrum RA,Botchway SW,Wharton CW,Hirst GJ

更新日期：2003-12-01 00:00:00

abstract：:The race for a vaccine against SARS-CoV-2 has accelerated research on RNA-based therapeutics. Beyond vaccines, RNA also shows great potential for cancer therapies. ...

journal_title：EMBO reports

authors： Rinaldi A

更新日期：2020-07-03 00:00:00

abstract：:Sulphatases undergo a unique post-translational modification that converts a highly conserved cysteine located within their active site into formylglycine. This modification is necessary for the catalytic activities of the sulphatases, and it is generated by the protein product of sulphatase-modifying factor 1 (SUMF1)...

journal_title：EMBO reports

authors： Zito E,Fraldi A,Pepe S,Annunziata I,Kobinger G,Di Natale P,Ballabio A,Cosma MP

更新日期：2005-07-01 00:00:00

abstract：:Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...

journal_title：EMBO reports

authors： Fritsch L,Martinez LA,Sekhri R,Naguibneva I,Gérard M,Vandromme M,Schaeffer L,Harel-Bellan A

更新日期：2004-02-01 00:00:00

abstract：:Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MD...

journal_title：EMBO reports

authors： Ji H,Ding Z,Hawke D,Xing D,Jiang BH,Mills GB,Lu Z

更新日期：2012-06-01 00:00:00

abstract：:Cohesin cofactors regulate the loading, maintenance, and release of cohesin complexes from chromosomes during mitosis but little is known on their role during vertebrate meiosis. One such cofactor is PDS5, which exists as two paralogs in somatic and germline cells, PDS5A and PDS5B, with unclear functions. Here, we hav...

journal_title：EMBO reports

authors： Viera A,Berenguer I,Ruiz-Torres M,Gómez R,Guajardo A,Barbero JL,Losada A,Suja JA

更新日期：2020-06-04 00:00:00

abstract：:Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector-parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA) knockout approach to determine the function of the mosquito antimicrobial peptide gene Defensin. We injected dsRNA into adul...

journal_title：EMBO reports

authors： Blandin S,Moita LF,Köcher T,Wilm M,Kafatos FC,Levashina EA

更新日期：2002-09-01 00:00:00

abstract：:Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome-dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of autophagosomes and lys...

journal_title：EMBO reports

authors： Wang Y,Huang Y,Liu J,Zhang J,Xu M,You Z,Peng C,Gong Z,Liu W

更新日期：2020-01-07 00:00:00

abstract：:Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000-4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. T...

journal_title：EMBO reports

authors： Capelson M,Hetzer MW

更新日期：2009-07-01 00:00:00

abstract：:Although iron is required for cell proliferation, iron-dependent programmed cell death serves as a critical barrier to tumor growth and metastasis. Emerging evidence suggests that iron-mediated lipid oxidation also facilitates immune eradication of cancer. However, the regulatory mechanisms of iron metabolism in cance...

journal_title：EMBO reports

authors： Song J,Liu T,Yin Y,Zhao W,Lin Z,Yin Y,Lu D,You F

更新日期：2021-01-04 00:00:00

abstract：:Post-translational protein arginylation is essential for cardiovascular development and angiogenesis in mice and is mediated by arginyl-transfer RNA-protein transferases Ate1-a functionally conserved but poorly understood class of enzymes. Here, we used sequence analysis to detect the evolutionary relationship between...

journal_title：EMBO reports

authors： Rai R,Mushegian A,Makarova K,Kashina A

更新日期：2006-08-01 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR)-catalyzed adenosine-to-inosine RNA editing is potentially dysregulated in neoplastic progression. However, how this transcriptome recoding process is functionally correlated with tumorigenesis remains largely elusive. Our analyses of RNA editome datasets identify hypoxia-relate...

journal_title：EMBO reports

authors： Ma CP,Liu H,Yi-Feng Chang I,Wang WC,Chen YT,Wu SM,Chen HW,Kuo YP,Shih CT,Li CY,Tan BC

更新日期：2019-05-01 00:00:00

abstract：:Caspase malfunction in stem cells often precedes the appearance and progression of multiple types of cancer, including human colorectal cancer. However, the caspase-dependent regulation of intestinal stem cell properties remains poorly understood. Here, we demonstrate that Dronc, the Drosophila ortholog of caspase-9/2...

journal_title：EMBO reports

authors： Arthurton L,Nahotko DA,Alonso J,Wendler F,Baena-Lopez LA

更新日期：2020-11-01 00:00:00