Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence.

abstract：:The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In a...

journal_title：EMBO reports

authors： Colombo R,Boggio R,Seiser C,Draetta GF,Chiocca S

更新日期：2002-11-01 00:00:00

abstract：:The tumour suppressor ARF (alternative reading frame), which is mutated or silenced in various tumours, has a crucial role in tumour surveillance to suppress unwarranted cell growth and proliferation. ARF has also been linked to the DNA-damage-induced response of p53 because of its ability to inhibit murine double min...

journal_title：EMBO reports

authors： Dominguez-Brauer C,Chen YJ,Brauer PM,Pimkina J,Raychaudhuri P

更新日期：2009-09-01 00:00:00

abstract：:Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP activity, inducing grow...

journal_title：EMBO reports

authors： Ito Y,Oinuma I,Katoh H,Kaibuchi K,Negishi M

更新日期：2006-07-01 00:00:00

abstract：:High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. Furthermore, we establish th...

journal_title：EMBO reports

authors： Mu Y,Lou J,Srivastava M,Zhao B,Feng XH,Liu T,Chen J,Huang J

更新日期：2016-01-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genome stability depends on RNases H1 and H2, which remove ribonucleotides from DNA and eliminate RNA-DNA hybrids (R-loops). In Schizosaccharomyces pombe, RNase H enzymes were reported to process RNA-DNA hybrids produced at a double-strand break (DSB) generated by I-PpoI meganuclease. Howe...

journal_title：EMBO reports

authors： Zhao H,Zhu M,Limbo O,Russell P

更新日期：2018-05-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms resi...

journal_title：EMBO reports

authors： Saeed S,Tremp AZ,Sharma V,Lasonder E,Dessens JT

更新日期：2020-03-04 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...

journal_title：EMBO reports

authors： Sordet O,Redon CE,Guirouilh-Barbat J,Smith S,Solier S,Douarre C,Conti C,Nakamura AJ,Das BB,Nicolas E,Kohn KW,Bonner WM,Pommier Y

更新日期：2009-08-01 00:00:00

abstract：:Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000-4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. T...

journal_title：EMBO reports

authors： Capelson M,Hetzer MW

更新日期：2009-07-01 00:00:00

abstract：:Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (...

journal_title：EMBO reports

authors： Chung J,Nakatsu F,Baskin JM,De Camilli P

更新日期：2015-03-01 00:00:00

abstract：:Myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. Analysis of highly conserved elements within vertebrate Myc proteins has been instrumental in defining the functions of the Myc protein. Here, we probe the role of a highly conserved, but little studied, element within the centr...

journal_title：EMBO reports

authors： Herbst A,Hemann MT,Tworkowski KA,Salghetti SE,Lowe SW,Tansey WP

更新日期：2005-02-01 00:00:00

abstract：:Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...

journal_title：EMBO reports

authors： Guo J,Polymenis M

更新日期：2006-11-01 00:00:00

abstract：:The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...

journal_title：EMBO reports

authors： Mak DO,Pearson JE,Loong KP,Datta S,Fernández-Mongil M,Foskett JK

更新日期：2007-11-01 00:00:00

abstract：:Subcellular organization is yielding to large-scale analysis. Researchers are now applying robust mass-spectrometry-based proteomics methods to obtain an inventory of biochemically isolated organelles that contain hundreds of proteins. High-resolution methods allow accurate protein identification, and novel algorithms...

journal_title：EMBO reports

authors： Andersen JS,Mann M

更新日期：2006-09-01 00:00:00

abstract：:It has been suggested that DNA methylation/demethylation is involved in regulating V(D)J rearrangement. Although methylated DNA is thought to induce an inaccessible chromatin structure, it is unclear whether DNA methylation can directly control V(D)J recombination independently of chromatin structure. In this study, w...

journal_title：EMBO reports

authors： Nakase H,Takahama Y,Akamatsu Y

更新日期：2003-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted ...

journal_title：EMBO reports

authors： de la Mata M,Gaidatzis D,Vitanescu M,Stadler MB,Wentzel C,Scheiffele P,Filipowicz W,Großhans H

更新日期：2015-04-01 00:00:00

abstract：:Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...

journal_title：EMBO reports

authors： Yan WW,Liang YL,Zhang QX,Wang D,Lei MZ,Qu J,He XH,Lei QY,Wang YP

更新日期：2018-12-01 00:00:00

abstract：:The systematic recording and management of experimental data in academic life science research remains an open problem. EPFL engaged in a program of ELN/LIMS deployment 6 years ago, encountering a host of fundamental questions at the institutional level and in each single laboratory. Here, based on our experience we a...

journal_title：EMBO reports

authors： Argento N

更新日期：2020-03-04 00:00:00

abstract：:A-kinase (or PKA)-anchoring protein AKAP95 is a zinc-finger protein implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. We have identified determinants of chromatin-binding, condensin-targeting and chromosome-condensation activities of AKAP95. Binding of AKAP95 to...

journal_title：EMBO reports

authors： Eide T,Carlson C,Taskén KA,Hirano T,Taskén K,Collas P

更新日期：2002-05-01 00:00:00

abstract：:Tie2, an endothelial cell-specific receptor kinase, has an important role in tumour angiogenesis. In an attempt to identify peptides that specifically interact with and block the Tie2 pathway, a phage-displayed peptide library was screened on a recombinant Tie2 receptor. One peptide, NLLMAAS, completely abolished the ...

journal_title：EMBO reports

authors： Tournaire R,Simon MP,le Noble F,Eichmann A,England P,Pouysségur J

更新日期：2004-03-01 00:00:00

abstract：:The eukaryotic GINS complex has an essential role in the initiation and elongation phases of genome duplication. It is composed of four paralogous subunits--Sld5, Psf1, Psf2 and Psf3--which are ubiquitous and evolutionarily conserved in eukaryotic organisms. Here, we report the biochemical characterization of the huma...

journal_title：EMBO reports

authors： De Falco M,Ferrari E,De Felice M,Rossi M,Hübscher U,Pisani FM

更新日期：2007-01-01 00:00:00

abstract：:Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make...

journal_title：EMBO reports

authors： Ochsenreiter T,Hajduk SL

更新日期：2006-11-01 00:00:00

abstract：:Although many signal transduction pathways have been implicated in the development of human disease, the identification of pathway targets and the biological processes that mediate disease progression remains challenging. One such disease-related pathway is the Janus kinase (JAK)/signal transducer and activator of tra...

journal_title：EMBO reports

authors： Bina S,Wright VM,Fisher KH,Milo M,Zeidler MP

更新日期：2010-03-01 00:00:00

abstract：:Howy Jacobs reminisces about his many editorials and asks whether they have ever been read by anyone. ...

journal_title：EMBO reports

authors： Jacobs H

更新日期：2020-07-03 00:00:00

abstract：:In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 antibody or expression of dominant-negative Rac1N17 led to an inversion ...

journal_title：EMBO reports

authors： Yu W,Shewan AM,Brakeman P,Eastburn DJ,Datta A,Bryant DM,Fan QW,Weiss WA,Zegers MM,Mostov KE

更新日期：2008-09-01 00:00:00

abstract：:The cytoplasm is the main place for protein translation from where nascent proteins are transported to their working areas, including the inside, outside, and membrane of the cell. The majority of newly synthesized membrane proteins is co-translationally inserted into the membrane by the evolutionary conserved Sec tra...

journal_title：EMBO reports

authors： Tanaka Y,Tsukazaki T

更新日期：2019-10-04 00:00:00

abstract：:Around 100 researchers gathered at the eighteenth EMBO Conference on 'The Molecular and Developmental Biology of Drosophila', which took place in Crete in June 2012. Whether deconstructing or integrating at the genetic, cellular or organ level, the talks highlighted the synergy of combining methods, approaches and dis...

journal_title：EMBO reports

authors： Miguel-Aliaga I,Oliver B,Teleman AA

更新日期：2012-11-06 00:00:00

abstract：:The Drosophila immune system is able to discriminate between classes of bacteria. Detection of Gram-positive bacteria involves a complex of two pattern recognition receptors: peptidoglycan recognition protein SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1). These activate the Toll signalling pathway. To defin...

journal_title：EMBO reports

authors： Filipe SR,Tomasz A,Ligoxygakis P

更新日期：2005-04-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:BAT-controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet-induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essent...

journal_title：EMBO reports

authors： Mahdaviani K,Benador IY,Su S,Gharakhanian RA,Stiles L,Trudeau KM,Cardamone M,Enríquez-Zarralanga V,Ritou E,Aprahamian T,Oliveira MF,Corkey BE,Perissi V,Liesa M,Shirihai OS

更新日期：2017-07-01 00:00:00