Abstract:
:Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MDM2 complex. This leads to the promotion of MDM2-p53 interaction and subsequent p53 degradation, thereby providing an antiapoptotic effect. Conversely, depletion of or deficiency in Niban expression promotes stabilization of p53 with increased cell apoptosis. Our findings illustrate a pivotal role for AKT-mediated phosphorylation of Niban in protecting cells from genotoxic stress-induced cell apoptosis.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Ji H,Ding Z,Hawke D,Xing D,Jiang BH,Mills GB,Lu Zdoi
10.1038/embor.2012.53subject
Has Abstractpub_date
2012-06-01 00:00:00pages
554-60issue
6eissn
1469-221Xissn
1469-3178pii
embor201253journal_volume
13pub_type
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