PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.

abstract：:Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological a...

journal_title：EMBO reports

authors： Lopez-Mejia IC,de Toledo M,Chavey C,Lapasset L,Cavelier P,Lopez-Herrera C,Chebli K,Fort P,Beranger G,Fajas L,Amri EZ,Casas F,Tazi J

更新日期：2014-05-01 00:00:00

abstract：:Howy Jacobs reminisces about his many editorials and asks whether they have ever been read by anyone. ...

journal_title：EMBO reports

authors： Jacobs H

更新日期：2020-07-03 00:00:00

abstract：:GlpF, the glycerol facilitator protein of Escherichia coli, is an archetypal member of the aquaporin superfamily. To assess its structure, recombinant histidine-tagged protein was overexpressed, solubilized in octylglucoside and purified to homogeneity. Negative stain electron microscopy of solubilized GlpF protein re...

journal_title：EMBO reports

authors： Braun T,Philippsen A,Wirtz S,Borgnia MJ,Agre P,Kühlbrandt W,Engel A,Stahlberg H

更新日期：2000-08-01 00:00:00

abstract：:In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA--U3, U14 and snR30--whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the pre-ribosome association to all 75 yeast snoRNAs in strains de...

journal_title：EMBO reports

authors： Bohnsack MT,Kos M,Tollervey D

更新日期：2008-12-01 00:00:00

abstract：:The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...

journal_title：EMBO reports

authors： Bomar MG,Pai MT,Tzeng SR,Li SS,Zhou P

更新日期：2007-03-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms resi...

journal_title：EMBO reports

authors： Saeed S,Tremp AZ,Sharma V,Lasonder E,Dessens JT

更新日期：2020-03-04 00:00:00

abstract：:The systematic recording and management of experimental data in academic life science research remains an open problem. EPFL engaged in a program of ELN/LIMS deployment 6 years ago, encountering a host of fundamental questions at the institutional level and in each single laboratory. Here, based on our experience we a...

journal_title：EMBO reports

authors： Argento N

更新日期：2020-03-04 00:00:00

abstract：:A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and disc...

journal_title：EMBO reports

authors： Chicas A,Macino G

更新日期：2001-11-01 00:00:00

abstract：:Centromeric constitutive heterochromatin is marked by DNA methylation and dimethylated histone H3 Lys 9 (H3K9me2) in Arabidopsis. RNA-directed DNA methylation (RdDM) is a process that uses 24-nucleotide (nt) small interfering RNAs (siRNAs) to induce de novo methylation to its homologous DNA sequences. Despite the pres...

journal_title：EMBO reports

authors： Schoft VK,Chumak N,Mosiolek M,Slusarz L,Komnenovic V,Brownfield L,Twell D,Kakutani T,Tamaru H

更新日期：2009-09-01 00:00:00

abstract：:The energy expending and glucose sink properties of brown adipose tissue (BAT) make it an attractive target for new obesity and diabetes treatments. Despite decades of research, only recently have mechanistic studies started to provide a more complete and consistent picture of how activated brown adipocytes handle glu...

journal_title：EMBO reports

authors： Hankir MK,Klingenspor M

更新日期：2018-09-01 00:00:00

abstract：:Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

journal_title：EMBO reports

authors： Harris RE,Ashe HL

更新日期：2011-06-01 00:00:00

abstract：:The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...

journal_title：EMBO reports

authors： Russo A,Goel P,Brace EJ,Buser C,Dickman D,DiAntonio A

更新日期：2019-03-01 00:00:00

abstract：:X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...

journal_title：EMBO reports

authors： Ng K,Pullirsch D,Leeb M,Wutz A

更新日期：2007-01-01 00:00:00

abstract：:The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evol...

journal_title：EMBO reports

authors： Smythe E,Ayscough KR

更新日期：2003-03-01 00:00:00

abstract：:Dynactin has been proposed to link the microtubule-associated motor cytoplasmic dynein with membranous cargo; however, the mechanism by which dynactin-membrane interaction is regulated is unknown. Here we show that dynein and dynactin exist in discrete cytosolic and membrane-bound states in the filamentous fungus Neur...

journal_title：EMBO reports

authors： Kumar S,Zhou Y,Plamann M

更新日期：2001-10-01 00:00:00

abstract：:The influence of circadian rhythms on memory has long been studied; however, the molecular prerequisites for their interaction remain elusive. The hippocampus, which is a region of the brain important for long-term memory formation and temporary maintenance, shows circadian rhythmicity in pathways central to the memor...

journal_title：EMBO reports

authors： Eckel-Mahan KL,Storm DR

更新日期：2009-06-01 00:00:00

abstract：:Zika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by w...

journal_title：EMBO reports

authors： Tiwari SK,Dang JW,Lin N,Qin Y,Wang S,Rana TM

更新日期：2020-10-19 00:00:00

abstract：:DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...

journal_title：EMBO reports

authors： Arias-Lopez C,Lazaro-Trueba I,Kerr P,Lord CJ,Dexter T,Iravani M,Ashworth A,Silva A

更新日期：2006-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted ...

journal_title：EMBO reports

authors： de la Mata M,Gaidatzis D,Vitanescu M,Stadler MB,Wentzel C,Scheiffele P,Filipowicz W,Großhans H

更新日期：2015-04-01 00:00:00

abstract：:RNA modifications represent a novel layer of regulation of gene expression. Functional experiments revealed that N6 -methyladenosine (m6 A) on messenger RNA (mRNA) plays critical roles in cell fate determination and development. m6 A mark also resides in the decoding center of 18S ribosomal RNA (rRNA); however, the bi...

journal_title：EMBO reports

authors： Xing M,Liu Q,Mao C,Zeng H,Zhang X,Zhao S,Chen L,Liu M,Shen B,Guo X,Ma H,Chen H,Zhang J

更新日期：2020-10-05 00:00:00

abstract：:The eukaryotic GINS complex has an essential role in the initiation and elongation phases of genome duplication. It is composed of four paralogous subunits--Sld5, Psf1, Psf2 and Psf3--which are ubiquitous and evolutionarily conserved in eukaryotic organisms. Here, we report the biochemical characterization of the huma...

journal_title：EMBO reports

authors： De Falco M,Ferrari E,De Felice M,Rossi M,Hübscher U,Pisani FM

更新日期：2007-01-01 00:00:00

abstract：:Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin can itself be phosphorylated at nearly every serine, threonine, and tyrosine residue. However, the effect of this modification on ubiquitin function is largely unknown....

journal_title：EMBO reports

authors： Swaney DL,Rodríguez-Mias RA,Villén J

更新日期：2015-09-01 00:00:00

abstract：:Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...

journal_title：EMBO reports

authors： Fritsch L,Martinez LA,Sekhri R,Naguibneva I,Gérard M,Vandromme M,Schaeffer L,Harel-Bellan A

更新日期：2004-02-01 00:00:00

abstract：:Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...

journal_title：EMBO reports

authors： Guo J,Polymenis M

更新日期：2006-11-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:N6-methyladenosine (m6A) is a highly dynamic RNA modification that has recently emerged as a key regulator of gene expression. While many m6A modifications are installed by the METTL3-METTL14 complex, others appear to be introduced independently, implying that additional human m6A methyltransferases remain to be ident...

journal_title：EMBO reports

authors： Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

更新日期：2017-11-01 00:00:00

abstract：:Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus-end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein-dependent spindle positioning. However, the mechanism of how Spindly regul...

journal_title：EMBO reports

authors： Tame MA,Raaijmakers JA,Afanasyev P,Medema RH

更新日期：2016-03-01 00:00:00

abstract：:Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer ...

journal_title：EMBO reports

authors： Xu X,Zhou H,Boyer TG

更新日期：2011-03-01 00:00:00

abstract：:Essential aspects of innate immune responses to microbial infections appear to be conserved between insects and mammals. In particular, in both groups, transmembrane receptors of the Toll superfamily play a crucial role in activating immune defenses. The Drosophila Toll family member 18-Wheeler had been proposed to se...

journal_title：EMBO reports

authors： Ligoxygakis P,Bulet P,Reichhart JM

更新日期：2002-07-01 00:00:00

abstract：:The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library of chromatin regulators. We identified genes involved in chromatin remodeling, sister ch...

journal_title：EMBO reports

authors： Warmerdam DO,Alonso-de Vega I,Wiegant WW,van den Broek B,Rother MB,Wolthuis RM,Freire R,van Attikum H,Medema RH,Smits VA

更新日期：2020-01-07 00:00:00