RNA to the rescue: RNA is one of the most promising targets for drug development given its wide variety of uses.

abstract：:Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and biochemical studies using a variety of different model systems have led to the discovery of 23 PEX genes required for this process. Although it is generally believed that, in contrast to mitochondria and chloroplasts, translocati...

journal_title：EMBO reports

authors： Einwächter H,Sowinski S,Kunau WH,Schliebs W

更新日期：2001-11-01 00:00:00

abstract：:Human immunodeficiency virus 1 (HIV-1) expresses several accessory proteins that manipulate various host-cell processes to achieve optimum replicative efficiency. One of them, viral protein U (Vpu), has been shown to interfere with the cellular degradation machinery through interaction with SCF(beta-TrCP) complexes. T...

journal_title：EMBO reports

authors： Leulier F,Marchal C,Miletich I,Limbourg-Bouchon B,Benarous R,Lemaitre B

更新日期：2003-10-01 00:00:00

abstract：:In Drosophila, the piRNA cluster, flamenco, produces most of the piRNAs (PIWI-interacting RNAs) that silence transposable elements in the somatic follicle cells during oogenesis. These piRNAs are thought to be processed from a long single-stranded precursor transcript. Here, we demonstrate that flamenco transcription ...

journal_title：EMBO reports

authors： Goriaux C,Desset S,Renaud Y,Vaury C,Brasset E

更新日期：2014-04-01 00:00:00

abstract：:Pair-rule genes in Drosophila integrate the positional information provided by the transcription factor gradients of gap genes and set the framework for the expression of the segment polarity genes. Pair-rule genes are also expressed during the segmentation of the short germ-band embryo of the flour beetle Tribolium, ...

journal_title：EMBO reports

authors： Eckert C,Aranda M,Wolff C,Tautz D

更新日期：2004-06-01 00:00:00

abstract：:Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...

journal_title：EMBO reports

authors： Munier AI,Doucet D,Perrodou E,Zachary D,Meister M,Hoffmann JA,Janeway CA Jr,Lagueux M

更新日期：2002-12-01 00:00:00

abstract：:Hydrogen sulfide (H2 S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis. By using xenograft orthotopic implantation of prostate cancer PC3 cells and subsequently comparing bone ...

journal_title：EMBO reports

authors： Wang YH,Huang JT,Chen WL,Wang RH,Kao MC,Pan YR,Chan SH,Tsai KW,Kung HJ,Lin KT,Wang LH

更新日期：2019-10-04 00:00:00

abstract：:Ku is a conserved heterodimeric DNA-binding protein that plays critical roles in DNA repair and telomere homeostasis. In Saccharomyces cerevisiae, deletion of YKU70 or YKU80 results in an inability to grow at 37 degrees C. This is suppressed by overexpression of several components of telomerase (EST1, EST2 and TLC1). ...

journal_title：EMBO reports

authors： Teo SH,Jackson SP

更新日期：2001-03-01 00:00:00

abstract：:The mechanisms that regulate the transcription of the tumour suppressor genes p53 and IRF-1 are poorly understood. We have characterized a 68-kDa transcription factor, GAAP-1 (gatekeeper of apoptosis activating proteins), encoded by an alternative splice product of the PRDII-BF1 gene, that recognizes a novel regulator...

journal_title：EMBO reports

authors： Lallemand C,Palmieri M,Blanchard B,Meritet JF,Tovey MG

更新日期：2002-02-01 00:00:00

abstract：:The cytoplasm is the main place for protein translation from where nascent proteins are transported to their working areas, including the inside, outside, and membrane of the cell. The majority of newly synthesized membrane proteins is co-translationally inserted into the membrane by the evolutionary conserved Sec tra...

journal_title：EMBO reports

authors： Tanaka Y,Tsukazaki T

更新日期：2019-10-04 00:00:00

abstract：:An effective immune response requires the engagement of host receptors by pathogen-derived molecules and the stimulation of an appropriate cellular response. Therefore, a crucial factor in our ability to control an infection is the accessibility of our immune cells to the foreign material. Exosomes-which are extracell...

journal_title：EMBO reports

authors： Schorey JS,Cheng Y,Singh PP,Smith VL

更新日期：2015-01-01 00:00:00

abstract：:The activation and transformation model of vertebrate nervous system formation posits that neural tissue is initially induced, or activated, with anterior forebrain character. Once established, a subset is then transformed into the more posterior midbrain, hindbrain, and spinal cord by signals emanating from the poste...

journal_title：EMBO reports

authors： Al Anber A,Martin BL

更新日期：2019-08-01 00:00:00

abstract：:The actin cytoskeleton operates in a multitude of cellular processes including cell shape and migration, mechanoregulation, and membrane or organelle dynamics. However, its filamentous properties and functions inside the mammalian cell nucleus are less well explored. We previously described transient actin assembly at...

journal_title：EMBO reports

authors： Krippner S,Winkelmeier J,Knerr J,Brandt DT,Virant D,Schwan C,Endesfelder U,Grosse R

更新日期：2020-11-05 00:00:00

abstract：:The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric enzyme complexes. Assembly factors assist in these biogenesis processes by providing co-factors or stabilizing transient assembly s...

journal_title：EMBO reports

authors： Wang C,Richter-Dennerlein R,Pacheu-Grau D,Liu F,Zhu Y,Dennerlein S,Rehling P

更新日期：2020-01-07 00:00:00

abstract：:The final irreversible step in the duplication and distribution of genomes to daughter cells takes place at the metaphase to anaphase transition. At this point aligned sister chromatid pairs split and separate. During metaphase, cohesion between sister chromatids is maintained by the chromosomal multi-subunit cohesin ...

journal_title：EMBO reports

authors： Uhlmann F

更新日期：2001-06-01 00:00:00

abstract：:Recruitment of beta-arrestin (beta-arr) to agonist-stimulated G-protein-coupled receptors (GPCRs) has a crucial role in controlling signalling efficacy and selectivity. When translocated to the receptor, beta-arr is believed to undergo important conformational rearrangement necessary for its downstream actions. To pro...

journal_title：EMBO reports

authors： Charest PG,Terrillon S,Bouvier M

更新日期：2005-04-01 00:00:00

abstract：:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, p...

journal_title：EMBO reports

authors： Sriram A,Bohlen J,Teleman AA

更新日期：2018-10-01 00:00:00

abstract：:Although eukaryotic G-protein coupled receptor (GPCR) systems are well known for their ability to detect and mediate rapid responses to extracellular signals, the full range of stimuli to which they respond may not yet have been identified. Activation of GPCRs by hormones, pheromones, odorants, neurotransmitters, ligh...

journal_title：EMBO reports

authors： Versele M,Lemaire K,Thevelein JM

更新日期：2001-07-01 00:00:00

abstract：:We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted beta-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induce...

journal_title：EMBO reports

authors： van de Wetering M,Oving I,Muncan V,Pon Fong MT,Brantjes H,van Leenen D,Holstege FC,Brummelkamp TR,Agami R,Clevers H

更新日期：2003-06-01 00:00:00

abstract：:IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebra...

journal_title：EMBO reports

authors： Hedman AC,Smith JM,Sacks DB

更新日期：2015-04-01 00:00:00

abstract：:The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that ...

journal_title：EMBO reports

authors： Gras S,Chaumont V,Fernandez B,Carpentier P,Charrier-Savournin F,Schmitt S,Pineau C,Flament D,Hecker A,Forterre P,Armengaud J,Housset D

更新日期：2007-06-01 00:00:00

abstract：:Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol 3,5-bisphosphate. ...

journal_title：EMBO reports

authors： Jefferies HB,Cooke FT,Jat P,Boucheron C,Koizumi T,Hayakawa M,Kaizawa H,Ohishi T,Workman P,Waterfield MD,Parker PJ

更新日期：2008-02-01 00:00:00

abstract：:WHITE COLLAR-1 (WC-1) is the limiting component of the White Collar Complex (WCC) controlling expression of the Neurospora circadian clock protein Frequency (FRQ). Accumulation of WC-1 is supported by FRQ on a post-transcriptional level. Here, we show that transcription of wc-1 is organized in a complex way. Three pro...

journal_title：EMBO reports

authors： Káldi K,González BH,Brunner M

更新日期：2006-02-01 00:00:00

abstract：:The active and inactive X chromosomes have distinct epigenetic marks in somatic nuclei, which undergo reprogramming after transplantation into oocytes. We show that, despite the disappearance of Xist RNA coating in 30 min, the epigenetic memory of the inactive X persists with the precocious appearance of histone H3 tr...

journal_title：EMBO reports

authors： Bao S,Miyoshi N,Okamoto I,Jenuwein T,Heard E,Azim Surani M

更新日期：2005-08-01 00:00:00

abstract：:In Drosophila, a cascade of maternal, gap, pair-rule and segment polarity genes subdivides the antero/posterior axis of the embryo into repeating segmental stripes. This review summarizes what happens next, i.e. how an intrasegmental pattern is generated and controls the differentiation of specific cell types in the e...

journal_title：EMBO reports

authors： Sanson B

更新日期：2001-12-01 00:00:00

abstract：:Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (...

journal_title：EMBO reports

authors： Chung J,Nakatsu F,Baskin JM,De Camilli P

更新日期：2015-03-01 00:00:00

abstract：:The function of protein phosphatase 1 nuclear-targeting subunit (PNUTS)--one of the most abundant nuclear-targeting subunits of protein phosphatase 1 (PP1c)--remains largely uncharacterized. We show that PNUTS depletion by small interfering RNA activates a G2 checkpoint in unperturbed cells and prolongs G2 checkpoint ...

journal_title：EMBO reports

authors： Landsverk HB,Mora-Bermúdez F,Landsverk OJ,Hasvold G,Naderi S,Bakke O,Ellenberg J,Collas P,Syljuåsen RG,Küntziger T

更新日期：2010-11-01 00:00:00

abstract：:In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulati...

journal_title：EMBO reports

authors： Shim HS,Kim H,Lee J,Son GH,Cho S,Oh TH,Kang SH,Seen DS,Lee KH,Kim K

更新日期：2007-04-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...

journal_title：EMBO reports

authors： Sordet O,Redon CE,Guirouilh-Barbat J,Smith S,Solier S,Douarre C,Conti C,Nakamura AJ,Das BB,Nicolas E,Kohn KW,Bonner WM,Pommier Y

更新日期：2009-08-01 00:00:00

abstract：:X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...

journal_title：EMBO reports

authors： Ng K,Pullirsch D,Leeb M,Wutz A

更新日期：2007-01-01 00:00:00

abstract：:The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (DeltaN-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length p53. Here, we s...

journal_title：EMBO reports

authors： Ray PS,Grover R,Das S

更新日期：2006-04-01 00:00:00