Abstract:
:In Drosophila, a cascade of maternal, gap, pair-rule and segment polarity genes subdivides the antero/posterior axis of the embryo into repeating segmental stripes. This review summarizes what happens next, i.e. how an intrasegmental pattern is generated and controls the differentiation of specific cell types in the epidermis. Within each segment, cells secreting the signalling molecules Wingless (the homologue of vertebrate Wnt-1) and Hedgehog are found in narrow stripes on both sides of the parasegmental boundary. The Wingless and Hedgehog organizing activities help to establish two more stripes per segment that localize ligands for the Epidermal Growth Factor and the Notch signalling pathways, respectively. These four signals then act at short range and in concert to control epidermal differentiation at the single cell level across the segment. This example from Drosophila provides a paradigm for how organizers generate precise patterns, and ultimately different cell types, in a naïve field of cells.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Sanson Bdoi
10.1093/embo-reports/kve255keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1083-8issue
12eissn
1469-221Xissn
1469-3178pii
2/12/1083journal_volume
2pub_type
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