New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.

abstract：:Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector-parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA) knockout approach to determine the function of the mosquito antimicrobial peptide gene Defensin. We injected dsRNA into adul...

journal_title：EMBO reports

authors： Blandin S,Moita LF,Köcher T,Wilm M,Kafatos FC,Levashina EA

更新日期：2002-09-01 00:00:00

abstract：:The angiotensin II type 1 (AT(1)) receptor is a G protein-coupled receptor that has a crucial role in the development of load-induced cardiac hypertrophy. Here, we show that cell stretch leads to activation of the AT(1) receptor, which undergoes an anticlockwise rotation and a shift of transmembrane (TM) 7 into the li...

journal_title：EMBO reports

authors： Yasuda N,Miura S,Akazawa H,Tanaka T,Qin Y,Kiya Y,Imaizumi S,Fujino M,Ito K,Zou Y,Fukuhara S,Kunimoto S,Fukuzaki K,Sato T,Ge J,Mochizuki N,Nakaya H,Saku K,Komuro I

更新日期：2008-02-01 00:00:00

abstract：:In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulati...

journal_title：EMBO reports

authors： Shim HS,Kim H,Lee J,Son GH,Cho S,Oh TH,Kang SH,Seen DS,Lee KH,Kim K

更新日期：2007-04-01 00:00:00

abstract：:Foxp3(+) regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)-like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg suppressor function ...

journal_title：EMBO reports

authors： Kitz A,de Marcken M,Gautron AS,Mitrovic M,Hafler DA,Dominguez-Villar M

更新日期：2016-08-01 00:00:00

abstract：:Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in...

journal_title：EMBO reports

authors： Holland AJ,Cleveland DW

更新日期：2012-06-01 00:00:00

abstract：:Tie2, an endothelial cell-specific receptor kinase, has an important role in tumour angiogenesis. In an attempt to identify peptides that specifically interact with and block the Tie2 pathway, a phage-displayed peptide library was screened on a recombinant Tie2 receptor. One peptide, NLLMAAS, completely abolished the ...

journal_title：EMBO reports

authors： Tournaire R,Simon MP,le Noble F,Eichmann A,England P,Pouysségur J

更新日期：2004-03-01 00:00:00

abstract：:Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...

journal_title：EMBO reports

authors： Munier AI,Doucet D,Perrodou E,Zachary D,Meister M,Hoffmann JA,Janeway CA Jr,Lagueux M

更新日期：2002-12-01 00:00:00

abstract：:Research into the extreme feats of endurance that humans and some animals achieve has uncovered a range of metabolic and physiological adaptations along with their evolutionary origins. ...

journal_title：EMBO reports

authors： Hunter P

更新日期：2019-11-05 00:00:00

abstract：:MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted ...

journal_title：EMBO reports

authors： de la Mata M,Gaidatzis D,Vitanescu M,Stadler MB,Wentzel C,Scheiffele P,Filipowicz W,Großhans H

更新日期：2015-04-01 00:00:00

abstract：:KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl- ) extruder critical for hyperpolarizing GABAA receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular inter...

journal_title：EMBO reports

authors： Mavrovic M,Uvarov P,Delpire E,Vutskits L,Kaila K,Puskarjov M

更新日期：2020-04-03 00:00:00

abstract：:Synaptic vesicles fuse with the plasma membrane in response to Ca(2+) influx, thereby releasing neurotransmitters into the synaptic cleft. The protein machinery that mediates this process, consisting of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and regulatory proteins, is well kno...

journal_title：EMBO reports

authors： Bharat TA,Malsam J,Hagen WJ,Scheutzow A,Söllner TH,Briggs JA

更新日期：2014-03-01 00:00:00

abstract：:Like many transcription regulators, histone methyltransferases G9a and G9a-like protein (GLP) can act gene-specifically as coregulators, but mechanisms controlling this specificity are mostly unknown. We show that adjacent post-translational methylation and phosphorylation regulate binding of G9a and GLP to heterochro...

journal_title：EMBO reports

authors： Poulard C,Bittencourt D,Wu DY,Hu Y,Gerke DS,Stallcup MR

更新日期：2017-08-01 00:00:00

abstract：:Chromosomal instability (CIN) refers to the rate at which cells are unable to properly segregate whole chromosomes, leading to aneuploidy. Besides its prevalence in cancer cells and postulated implications in promoting tumorigenesis, studies in aneuploidy-prone mouse models uncovered an unanticipated link between CIN ...

journal_title：EMBO reports

authors： Barroso-Vilares M,Macedo JC,Reis M,Warren JD,Compton D,Logarinho E

更新日期：2020-05-06 00:00:00

abstract：:Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...

journal_title：EMBO reports

authors： Cao L,Wei D,Reid B,Zhao S,Pu J,Pan T,Yamoah E,Zhao M

更新日期：2013-02-01 00:00:00

abstract：:We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nasce...

journal_title：EMBO reports

authors： Gold VA,Chroscicki P,Bragoszewski P,Chacinska A

更新日期：2017-10-01 00:00:00

abstract：:RNA silencing is a complex of mechanisms that regulate gene expression through small RNA molecules. The microRNA (miRNA) pathway is the most common of these in mammals. Genome-encoded miRNAs suppress translation in a sequence-specific manner and facilitate shifts in gene expression during developmental transitions. He...

journal_title：EMBO reports

authors： Svoboda P,Flemr M

更新日期：2010-08-01 00:00:00

abstract：:Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MD...

journal_title：EMBO reports

authors： Ji H,Ding Z,Hawke D,Xing D,Jiang BH,Mills GB,Lu Z

更新日期：2012-06-01 00:00:00

abstract：:Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer ...

journal_title：EMBO reports

authors： Xu X,Zhou H,Boyer TG

更新日期：2011-03-01 00:00:00

abstract：:BAT-controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet-induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essent...

journal_title：EMBO reports

authors： Mahdaviani K,Benador IY,Su S,Gharakhanian RA,Stiles L,Trudeau KM,Cardamone M,Enríquez-Zarralanga V,Ritou E,Aprahamian T,Oliveira MF,Corkey BE,Perissi V,Liesa M,Shirihai OS

更新日期：2017-07-01 00:00:00

abstract：:The imprint at the mat1 locus of Schizosaccharomyces pombe acts to initiate the replication-coupled recombination event that underlies mating-type switching. However, the nature of the imprint has been an area of dispute. Two alternative models have been proposed: one stated that the imprint is a nick in the DNA, wher...

journal_title：EMBO reports

authors： Vengrova S,Dalgaard JZ

更新日期：2006-01-01 00:00:00

abstract：:A previously uncharacterized putative ion channel, NALCN (sodium leak channel, non-selective), has been recently shown to be responsible for the tetrodotoxin (TTX)-resistant sodium leak current implicated in the regulation of neuronal excitability. Here, we show that NALCN encodes a current that is activated by M3 mus...

journal_title：EMBO reports

authors： Swayne LA,Mezghrani A,Varrault A,Chemin J,Bertrand G,Dalle S,Bourinet E,Lory P,Miller RJ,Nargeot J,Monteil A

更新日期：2009-08-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:The influence of circadian rhythms on memory has long been studied; however, the molecular prerequisites for their interaction remain elusive. The hippocampus, which is a region of the brain important for long-term memory formation and temporary maintenance, shows circadian rhythmicity in pathways central to the memor...

journal_title：EMBO reports

authors： Eckel-Mahan KL,Storm DR

更新日期：2009-06-01 00:00:00

abstract：:Howy Jacobs reminisces about his many editorials and asks whether they have ever been read by anyone. ...

journal_title：EMBO reports

authors： Jacobs H

更新日期：2020-07-03 00:00:00

abstract：:Histone deacetylases (HDACs)-an enzyme family that deacetylates histones and non-histone proteins-are implicated in human diseases such as cancer, and the first-generation of HDAC inhibitors are now in clinical trials. Here, we report the 2.0 A resolution crystal structure of a catalytically inactive HDAC8 active-site...

journal_title：EMBO reports

authors： Vannini A,Volpari C,Gallinari P,Jones P,Mattu M,Carfí A,De Francesco R,Steinkühler C,Di Marco S

更新日期：2007-09-01 00:00:00

abstract：:Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiol...

journal_title：EMBO reports

authors： Fu Y,Rubin CS

更新日期：2011-07-08 00:00:00

abstract：:The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...

journal_title：EMBO reports

authors： Ernst HA,Olsen AN,Larsen S,Lo Leggio L

更新日期：2004-03-01 00:00:00

abstract：:Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of re...

journal_title：EMBO reports

authors： Lefebvre B,Ozato K,Lefebvre P

更新日期：2002-04-01 00:00:00

abstract：:The tubby loci provide a unique opportunity to study adult-onset obesity. Mutation in either mammalian tubby or its homologue in Caenorhabditis elegans, tub-1, results in increased fat storage. Previously, we have shown that TUB-1 interacts with a new Rab GTPase-activating protein, RBG-3, for the regulation of fat sto...

journal_title：EMBO reports

authors： Mukhopadhyay A,Pan X,Lambright DG,Tissenbaum HA

更新日期：2007-10-01 00:00:00

abstract：:There is a great interest in determining the impact of p53 on ageing and, for this, it is important to discriminate among the known causes of ageing. Telomere loss is a well-established source of age-associated damage, which by itself can recapitulate ageing in mouse models. Here, we have used a genetic approach to in...

journal_title：EMBO reports

authors： García-Cao I,García-Cao M,Tomás-Loba A,Martín-Caballero J,Flores JM,Klatt P,Blasco MA,Serrano M

更新日期：2006-05-01 00:00:00