Abstract:
:Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Holland AJ,Cleveland DWdoi
10.1038/embor.2012.55subject
Has Abstractpub_date
2012-06-01 00:00:00pages
501-14issue
6eissn
1469-221Xissn
1469-3178pii
embor201255journal_volume
13pub_type
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