Abstract:
:Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make a stable mRNA. This alternatively edited mRNA is translated to produce a unique protein that fractionates with mitochondrial membranes and colocalizes with mitochondrial proteins in situ. Alternative RNA editing represents a previously unknown mechanism generating protein diversity and, as such, represents an important function for RNA editing.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Ochsenreiter T,Hajduk SLdoi
10.1038/sj.embor.7400817subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1128-33issue
11eissn
1469-221Xissn
1469-3178pii
7400817journal_volume
7pub_type
杂志文章相关文献
EMBO REPORTS文献大全abstract::Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201847407
更新日期:2019-04-01 00:00:00
abstract::Sepsis, or blood poisoning, is a savage response of the body to infection. It can lead to organ failure, blood pressure decline, heart failure, and coma. Between 20 and 30 million people suffer from sepsis each year, leading to 8 million deaths. Although certain people are more at risk than others (young children, eld...
journal_title:EMBO reports
pub_type: 评论,新闻
doi:10.15252/embr.201949193
更新日期:2020-01-07 00:00:00
abstract::The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400093
更新日期:2004-03-01 00:00:00
abstract::The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400901
更新日期:2007-03-01 00:00:00
abstract::RNA silencing is a complex of mechanisms that regulate gene expression through small RNA molecules. The microRNA (miRNA) pathway is the most common of these in mammals. Genome-encoded miRNAs suppress translation in a sequence-specific manner and facilitate shifts in gene expression during developmental transitions. He...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2010.102
更新日期:2010-08-01 00:00:00
abstract::Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV). The role of TRPML1 in cell function and how the mutations cause the disease are not well understood. Most studies focus on the role of TRPML1 in constitutive membrane trafficking to and from the lysosomes. However, this cannot explai...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201541542
更新日期:2016-02-01 00:00:00
abstract::Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2012.215
更新日期:2013-02-01 00:00:00
abstract::The first EMBO Conference on Experimental Approaches to Evolution and Ecology in Yeast was held in Heidelberg, Germany, at the end of September 2010. What might sound like a rather narrow topic actually covered a broad range of interests, approaches, and systems and generated a great deal of excitement among participa...
journal_title:EMBO reports
pub_type:
doi:10.1038/embor.2010.204
更新日期:2011-01-01 00:00:00
abstract::Centromeric constitutive heterochromatin is marked by DNA methylation and dimethylated histone H3 Lys 9 (H3K9me2) in Arabidopsis. RNA-directed DNA methylation (RdDM) is a process that uses 24-nucleotide (nt) small interfering RNAs (siRNAs) to induce de novo methylation to its homologous DNA sequences. Despite the pres...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.152
更新日期:2009-09-01 00:00:00
abstract::Zika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by w...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201949183
更新日期:2020-10-19 00:00:00
abstract::Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400088
更新日期:2004-03-01 00:00:00
abstract::Human immunodeficiency virus 1 (HIV-1) expresses several accessory proteins that manipulate various host-cell processes to achieve optimum replicative efficiency. One of them, viral protein U (Vpu), has been shown to interfere with the cellular degradation machinery through interaction with SCF(beta-TrCP) complexes. T...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.embor936
更新日期:2003-10-01 00:00:00
abstract::Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome-dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of autophagosomes and lys...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948335
更新日期:2020-01-07 00:00:00
abstract::Codon bias has been implicated as one of the major factors contributing to mRNA stability in several model organisms. However, the molecular mechanisms of codon bias on mRNA stability remain unclear in humans. Here, we show that human cells possess a mechanism to modulate RNA stability through a unique codon bias. Bio...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948220
更新日期:2019-11-05 00:00:00
abstract::The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201846975
更新日期:2019-03-01 00:00:00
abstract::We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means of a P-element insertional genetic screen. Helicase89B belongs to the Mot1p/BTAF1 subfamily of SNF2-like ATPases. This subfamily can interact with TATA-binding proteins, but whethe...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400542
更新日期:2005-11-01 00:00:00
abstract::High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. Furthermore, we establish th...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201540964
更新日期:2016-01-01 00:00:00
abstract::Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological a...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1002/embr.201338126
更新日期:2014-05-01 00:00:00
abstract::Potentially pathogenic bacteria, such as Escherichia coli and Vibrio cholerae, become non-culturable during stasis. The analysis of such cells has been hampered by difficulties in studying bacterial population heterogeneity. Using in situ detection of protein oxidation in single E. coli cells, and using a density-grad...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.embor799
更新日期:2003-04-01 00:00:00
abstract::Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication init...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201643347
更新日期:2017-11-01 00:00:00
abstract::Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for th...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kve008
更新日期:2001-01-01 00:00:00
abstract::Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condi...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051668
更新日期:2020-10-05 00:00:00
abstract::The role of long noncoding RNAs (lncRNAs) in viral infection is poorly studied. We have identified hepatitis C virus (HCV)-Stimulated lncRNAs (CSRs) by transcriptome analysis. Interestingly, two of these CSRs (PVT1 and UCA1) play relevant roles in tumorigenesis, providing a novel link between HCV infection and develop...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201541763
更新日期:2016-07-01 00:00:00
abstract::The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...
journal_title:EMBO reports
pub_type: 评论,杂志文章
doi:10.1002/embr.201438446
更新日期:2014-03-01 00:00:00
abstract::The high-mobility-group B (HMGB) chromosomal proteins are characterized by the HMG box, a DNA-binding domain that both introduces a tight bend into DNA and binds preferentially to a variety of distorted DNA structures. The HMGB proteins seem to act primarily as architectural facilitators in the manipulation of nucleop...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/sj.embor.embor741
更新日期:2003-02-01 00:00:00
abstract::Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MD...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2012.53
更新日期:2012-06-01 00:00:00
abstract::Although eukaryotic G-protein coupled receptor (GPCR) systems are well known for their ability to detect and mediate rapid responses to extracellular signals, the full range of stimuli to which they respond may not yet have been identified. Activation of GPCRs by hormones, pheromones, odorants, neurotransmitters, ligh...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kve132
更新日期:2001-07-01 00:00:00
abstract::Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD). Mitophagy, a cargo-specific autophagy for elimination of dysfunctional mitochondria, constitutes a key quality control mechanism. However, ho...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201949801
更新日期:2020-09-03 00:00:00
abstract::Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5/Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5-null mouse em...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948469
更新日期:2020-01-07 00:00:00
abstract::The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling. In this study, phenotype analysis of knockin/knockout Lgr5-eGFP-IRES-Cre and Lgr5-DTReGFP embryos reveals that Lgr5 deficiency during Wnt-mediated cytodifferentiation results in amplification of ISCs and early differe...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201949224
更新日期:2020-07-03 00:00:00