The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.

abstract：:The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric enzyme complexes. Assembly factors assist in these biogenesis processes by providing co-factors or stabilizing transient assembly s...

journal_title：EMBO reports

authors： Wang C,Richter-Dennerlein R,Pacheu-Grau D,Liu F,Zhu Y,Dennerlein S,Rehling P

更新日期：2020-01-07 00:00:00

abstract：:Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and pa...

journal_title：EMBO reports

authors： Escobar-Henriques M,Langer T

更新日期：2014-03-01 00:00:00

abstract：:PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by f...

journal_title：EMBO reports

authors： Muñoz IM,Rouse J

更新日期：2009-03-01 00:00:00

abstract：:The biosynthesis of RNA includes its post-transcriptional modifications, and the crucial functions of these modifications have supported their conservation within all three kingdoms. For example, the modifications located within or adjacent to the anticodon of the transfer RNA (tRNA) enhance the accuracy of codon bind...

journal_title：EMBO reports

authors： Agris PF

更新日期：2008-07-01 00:00:00

abstract：:The cytosolic pathogen sensor RIG-I is activated by RNAs with exposed 5'-triphosphate (5'-ppp) and terminal double-stranded structures, such as those that are generated during viral infection. RIG-I has been shown to translocate on dsRNA in an ATP-dependent manner. However, the precise role of the ATPase activity in R...

journal_title：EMBO reports

authors： Patel JR,Jain A,Chou YY,Baum A,Ha T,García-Sastre A

更新日期：2013-09-01 00:00:00

abstract：:Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV). The role of TRPML1 in cell function and how the mutations cause the disease are not well understood. Most studies focus on the role of TRPML1 in constitutive membrane trafficking to and from the lysosomes. However, this cannot explai...

journal_title：EMBO reports

authors： Park S,Ahuja M,Kim MS,Brailoiu GC,Jha A,Zeng M,Baydyuk M,Wu LG,Wassif CA,Porter FD,Zerfas PM,Eckhaus MA,Brailoiu E,Shin DM,Muallem S

更新日期：2016-02-01 00:00:00

abstract：:Although eukaryotic G-protein coupled receptor (GPCR) systems are well known for their ability to detect and mediate rapid responses to extracellular signals, the full range of stimuli to which they respond may not yet have been identified. Activation of GPCRs by hormones, pheromones, odorants, neurotransmitters, ligh...

journal_title：EMBO reports

authors： Versele M,Lemaire K,Thevelein JM

更新日期：2001-07-01 00:00:00

abstract：:The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...

journal_title：EMBO reports

authors： Ernst HA,Olsen AN,Larsen S,Lo Leggio L

更新日期：2004-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted ...

journal_title：EMBO reports

authors： de la Mata M,Gaidatzis D,Vitanescu M,Stadler MB,Wentzel C,Scheiffele P,Filipowicz W,Großhans H

更新日期：2015-04-01 00:00:00

abstract：:Labmates are colleagues, friends, comforters…and competitors. ...

journal_title：EMBO reports

authors： Morriswood B,Hoeller O

更新日期：2019-07-01 00:00:00

abstract：:BAT-controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet-induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essent...

journal_title：EMBO reports

authors： Mahdaviani K,Benador IY,Su S,Gharakhanian RA,Stiles L,Trudeau KM,Cardamone M,Enríquez-Zarralanga V,Ritou E,Aprahamian T,Oliveira MF,Corkey BE,Perissi V,Liesa M,Shirihai OS

更新日期：2017-07-01 00:00:00

abstract：:Sepsis, or blood poisoning, is a savage response of the body to infection. It can lead to organ failure, blood pressure decline, heart failure, and coma. Between 20 and 30 million people suffer from sepsis each year, leading to 8 million deaths. Although certain people are more at risk than others (young children, eld...

journal_title：EMBO reports

authors： Van Looveren K,Van Wyngene L,Libert C

更新日期：2020-01-07 00:00:00

abstract：:Dynactin has been proposed to link the microtubule-associated motor cytoplasmic dynein with membranous cargo; however, the mechanism by which dynactin-membrane interaction is regulated is unknown. Here we show that dynein and dynactin exist in discrete cytosolic and membrane-bound states in the filamentous fungus Neur...

journal_title：EMBO reports

authors： Kumar S,Zhou Y,Plamann M

更新日期：2001-10-01 00:00:00

abstract：:In response to a variety of stresses, mammalian cells undergo a persistent proliferative arrest known as cellular senescence. Many senescence-inducing stressors are potentially oncogenic, strengthening the notion that senescence evolved alongside apoptosis to suppress tumorigenesis. In contrast to apoptosis, senescent...

journal_title：EMBO reports

authors： Childs BG,Baker DJ,Kirkland JL,Campisi J,van Deursen JM

更新日期：2014-11-01 00:00:00

abstract：:Stat1 (signal transducer and activator of transcription 1) regulates transcription in response to the type I interferons IFN-alpha and IFN-beta, either in its dimerized form or as a subunit of the interferon-stimulated gene factor 3 (Isgf3) complex (consisting of Stat1, Stat2 and interferon-regulating factor 9). Full-...

journal_title：EMBO reports

authors： Pilz A,Ramsauer K,Heidari H,Leitges M,Kovarik P,Decker T

更新日期：2003-04-01 00:00:00

abstract：:The actin cytoskeleton operates in a multitude of cellular processes including cell shape and migration, mechanoregulation, and membrane or organelle dynamics. However, its filamentous properties and functions inside the mammalian cell nucleus are less well explored. We previously described transient actin assembly at...

journal_title：EMBO reports

authors： Krippner S,Winkelmeier J,Knerr J,Brandt DT,Virant D,Schwan C,Endesfelder U,Grosse R

更新日期：2020-11-05 00:00:00

abstract：:GlpF, the glycerol facilitator protein of Escherichia coli, is an archetypal member of the aquaporin superfamily. To assess its structure, recombinant histidine-tagged protein was overexpressed, solubilized in octylglucoside and purified to homogeneity. Negative stain electron microscopy of solubilized GlpF protein re...

journal_title：EMBO reports

authors： Braun T,Philippsen A,Wirtz S,Borgnia MJ,Agre P,Kühlbrandt W,Engel A,Stahlberg H

更新日期：2000-08-01 00:00:00

abstract：:The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...

journal_title：EMBO reports

authors： Bomar MG,Pai MT,Tzeng SR,Li SS,Zhou P

更新日期：2007-03-01 00:00:00

abstract：:Streptococcus pneumoniae causes more than one million deaths every year, mostly of young children in developing countries, due to pneumonia, bacteremia and meningitis. The emergence and dissemination of drug-resistant pneumococcal strains, coupled to changing patterns of virulence and the inadequacy of available vacci...

journal_title：EMBO reports

authors： Di Guilmi AM,Dessen A

更新日期：2002-08-01 00:00:00

abstract：:Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been ident...

journal_title：EMBO reports

authors： Sakata E,Yamaguchi Y,Kurimoto E,Kikuchi J,Yokoyama S,Yamada S,Kawahara H,Yokosawa H,Hattori N,Mizuno Y,Tanaka K,Kato K

更新日期：2003-03-01 00:00:00

abstract：:Global climate change and the increasing human population require crop varieties with higher yield and draught resistance. But meeting both goals is not an easy task for breeders and plant science. ...

journal_title：EMBO reports

authors： Moshelion M

更新日期：2020-11-29 00:00:00

abstract：:The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondr...

journal_title：EMBO reports

authors： Braschi E,Zunino R,McBride HM

更新日期：2009-07-01 00:00:00

abstract：:The first EMBO Conference on Experimental Approaches to Evolution and Ecology in Yeast was held in Heidelberg, Germany, at the end of September 2010. What might sound like a rather narrow topic actually covered a broad range of interests, approaches, and systems and generated a great deal of excitement among participa...

journal_title：EMBO reports

authors： Dunham MJ,Louis EJ

更新日期：2011-01-01 00:00:00

abstract：:Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol 3,5-bisphosphate. ...

journal_title：EMBO reports

authors： Jefferies HB,Cooke FT,Jat P,Boucheron C,Koizumi T,Hayakawa M,Kaizawa H,Ohishi T,Workman P,Waterfield MD,Parker PJ

更新日期：2008-02-01 00:00:00

abstract：:Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that N...

journal_title：EMBO reports

authors： Sundqvist A,Liu G,Mirsaliotis A,Xirodimas DP

更新日期：2009-10-01 00:00:00

abstract：:Potentially pathogenic bacteria, such as Escherichia coli and Vibrio cholerae, become non-culturable during stasis. The analysis of such cells has been hampered by difficulties in studying bacterial population heterogeneity. Using in situ detection of protein oxidation in single E. coli cells, and using a density-grad...

journal_title：EMBO reports

authors： Desnues B,Cuny C,Grégori G,Dukan S,Aguilaniu H,Nyström T

更新日期：2003-04-01 00:00:00

abstract：:Loss of the retinoblastoma protein, pRB, leads to apoptosis, and several results have suggested that this is dependent on the E2F transcription factors. However, so far, the ability of the different E2F family members to contribute to apoptosis is controversial. Here, we show that ectopic expression of E2F3 results in...

journal_title：EMBO reports

authors： Lazzerini Denchi E,Helin K

更新日期：2005-07-01 00:00:00

abstract：:We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nasce...

journal_title：EMBO reports

authors： Gold VA,Chroscicki P,Bragoszewski P,Chacinska A

更新日期：2017-10-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (DeltaN-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length p53. Here, we s...

journal_title：EMBO reports

authors： Ray PS,Grover R,Das S

更新日期：2006-04-01 00:00:00