Differential oxidative damage and expression of stress defence regulons in culturable and non-culturable Escherichia coli cells.

abstract：:Cohesin cofactors regulate the loading, maintenance, and release of cohesin complexes from chromosomes during mitosis but little is known on their role during vertebrate meiosis. One such cofactor is PDS5, which exists as two paralogs in somatic and germline cells, PDS5A and PDS5B, with unclear functions. Here, we hav...

journal_title：EMBO reports

authors： Viera A,Berenguer I,Ruiz-Torres M,Gómez R,Guajardo A,Barbero JL,Losada A,Suja JA

更新日期：2020-06-04 00:00:00

abstract：:Despite its limited resources, Portugal has gained a prominent position in research on malaria. Several historical and personal factors have contributed to this achievement. ...

journal_title：EMBO reports

authors： Prudêncio M

更新日期：2021-01-10 00:00:00

abstract：:The mechanisms that regulate the transcription of the tumour suppressor genes p53 and IRF-1 are poorly understood. We have characterized a 68-kDa transcription factor, GAAP-1 (gatekeeper of apoptosis activating proteins), encoded by an alternative splice product of the PRDII-BF1 gene, that recognizes a novel regulator...

journal_title：EMBO reports

authors： Lallemand C,Palmieri M,Blanchard B,Meritet JF,Tovey MG

更新日期：2002-02-01 00:00:00

abstract：:Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and pa...

journal_title：EMBO reports

authors： Escobar-Henriques M,Langer T

更新日期：2014-03-01 00:00:00

abstract：:The systematic recording and management of experimental data in academic life science research remains an open problem. EPFL engaged in a program of ELN/LIMS deployment 6 years ago, encountering a host of fundamental questions at the institutional level and in each single laboratory. Here, based on our experience we a...

journal_title：EMBO reports

authors： Argento N

更新日期：2020-03-04 00:00:00

abstract：:Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome-dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of autophagosomes and lys...

journal_title：EMBO reports

authors： Wang Y,Huang Y,Liu J,Zhang J,Xu M,You Z,Peng C,Gong Z,Liu W

更新日期：2020-01-07 00:00:00

abstract：:RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prior work revealed that intestinal epithelial cell-specific Imp1 deletio...

journal_title：EMBO reports

authors： Chatterji P,Williams PA,Whelan KA,Samper FC,Andres SF,Simon LA,Parham LR,Mizuno R,Lundsmith ET,Lee DS,Liang S,Wijeratne HS,Marti S,Chau L,Giroux V,Wilkins BJ,Wu GD,Shah P,Tartaglia GG,Hamilton KE

更新日期：2019-06-01 00:00:00

abstract：:Autophagosome formation is promoted by the PI3 kinase complex and negatively regulated by myotubularin phosphatases, indicating that regulation of local phosphatidylinositol 3-phosphate (PtdIns3P) levels is important for this early phase of autophagy. Here, we show that the Caenorhabditis elegans myotubularin phosphat...

journal_title：EMBO reports

authors： Wu Y,Cheng S,Zhao H,Zou W,Yoshina S,Mitani S,Zhang H,Wang X

更新日期：2014-09-01 00:00:00

abstract：:STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250 partners of STK38 and find that STK38 modulates its partnership depending on the cellular context by increa...

journal_title：EMBO reports

authors： Martin AP,Jacquemyn M,Lipecka J,Chhuon C,Aushev VN,Meunier B,Singh MK,Carpi N,Piel M,Codogno P,Hergovich A,Parrini MC,Zalcman G,Guerrera IC,Daelemans D,Camonis JH

更新日期：2019-11-05 00:00:00

abstract：:Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have relied mainly on the use of commercial Staphylococcus aureus PG and have not addressed TLR2 recognition of other PG type...

journal_title：EMBO reports

authors： Travassos LH,Girardin SE,Philpott DJ,Blanot D,Nahori MA,Werts C,Boneca IG

更新日期：2004-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have significant side effects. A...

journal_title：EMBO reports

authors： Ploss A,Rice CM

更新日期：2009-11-01 00:00:00

abstract：:Sulphatases undergo a unique post-translational modification that converts a highly conserved cysteine located within their active site into formylglycine. This modification is necessary for the catalytic activities of the sulphatases, and it is generated by the protein product of sulphatase-modifying factor 1 (SUMF1)...

journal_title：EMBO reports

authors： Zito E,Fraldi A,Pepe S,Annunziata I,Kobinger G,Di Natale P,Ballabio A,Cosma MP

更新日期：2005-07-01 00:00:00

abstract：:A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and disc...

journal_title：EMBO reports

authors： Chicas A,Macino G

更新日期：2001-11-01 00:00:00

abstract：:Acetaminophen/paracetamol-induced liver failure--which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption--is exacerbated by fasting. As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residues, we investigat...

journal_title：EMBO reports

authors： Lu Z,Bourdi M,Li JH,Aponte AM,Chen Y,Lombard DB,Gucek M,Pohl LR,Sack MN

更新日期：2011-07-01 00:00:00

abstract：:Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-p...

journal_title：EMBO reports

authors： Hwang G,Kim S,Cho JY,Paik I,Kim JI,Oh E

更新日期：2019-10-04 00:00:00

abstract：:TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For exampl...

journal_title：EMBO reports

authors： Durán RV,Hall MN

更新日期：2012-02-01 00:00:00

abstract：:The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated. Specifically, the precise contribution o...

journal_title：EMBO reports

authors： Bonora M,Morganti C,Morciano G,Pedriali G,Lebiedzinska-Arciszewska M,Aquila G,Giorgi C,Rizzo P,Campo G,Ferrari R,Kroemer G,Wieckowski MR,Galluzzi L,Pinton P

更新日期：2017-07-01 00:00:00

abstract：:The Vav family of proteins are guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases, which regulate various cellular functions, including T-cell activation. They contain a catalytic Dbl homology (DH) domain that is invariably followed by a pleckstrin homology (PH) domain, which is often required fo...

journal_title：EMBO reports

authors： Rapley J,Tybulewicz VL,Rittinger K

更新日期：2008-07-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:Centromeric constitutive heterochromatin is marked by DNA methylation and dimethylated histone H3 Lys 9 (H3K9me2) in Arabidopsis. RNA-directed DNA methylation (RdDM) is a process that uses 24-nucleotide (nt) small interfering RNAs (siRNAs) to induce de novo methylation to its homologous DNA sequences. Despite the pres...

journal_title：EMBO reports

authors： Schoft VK,Chumak N,Mosiolek M,Slusarz L,Komnenovic V,Brownfield L,Twell D,Kakutani T,Tamaru H

更新日期：2009-09-01 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:Sonic hedgehog (Shh), both as a mitogen and as a morphogen, plays an important role in cell proliferation and differentiation during early development. Here, we show that Shh inhibits glutamate transporter activities in neurons, rapidly enhances extracellular glutamate levels, and affects the development of epilepsy. ...

journal_title：EMBO reports

authors： Feng S,Ma S,Jia C,Su Y,Yang S,Zhou K,Liu Y,Cheng J,Lu D,Fan L,Wang Y

更新日期：2016-05-01 00:00:00

abstract：:The energy expending and glucose sink properties of brown adipose tissue (BAT) make it an attractive target for new obesity and diabetes treatments. Despite decades of research, only recently have mechanistic studies started to provide a more complete and consistent picture of how activated brown adipocytes handle glu...

journal_title：EMBO reports

authors： Hankir MK,Klingenspor M

更新日期：2018-09-01 00:00:00

abstract：:The imprint at the mat1 locus of Schizosaccharomyces pombe acts to initiate the replication-coupled recombination event that underlies mating-type switching. However, the nature of the imprint has been an area of dispute. Two alternative models have been proposed: one stated that the imprint is a nick in the DNA, wher...

journal_title：EMBO reports

authors： Vengrova S,Dalgaard JZ

更新日期：2006-01-01 00:00:00

abstract：:The biosynthesis of RNA includes its post-transcriptional modifications, and the crucial functions of these modifications have supported their conservation within all three kingdoms. For example, the modifications located within or adjacent to the anticodon of the transfer RNA (tRNA) enhance the accuracy of codon bind...

journal_title：EMBO reports

authors： Agris PF

更新日期：2008-07-01 00:00:00

abstract：:The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto-inhibition. However, the molecular mechanism underlying Nedd4 E3 auto-inhibition and activation is poorly un...

journal_title：EMBO reports

authors： Zhu K,Shan Z,Chen X,Cai Y,Cui L,Yao W,Wang Z,Shi P,Tian C,Lou J,Xie Y,Wen W

更新日期：2017-09-01 00:00:00

abstract：:Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway and that EVs released from M.tb-infec...

journal_title：EMBO reports

authors： Cheng Y,Schorey JS

更新日期：2019-03-01 00:00:00

abstract：:Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer ...

journal_title：EMBO reports

authors： Xu X,Zhou H,Boyer TG

更新日期：2011-03-01 00:00:00

abstract：:DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...

journal_title：EMBO reports

authors： Arias-Lopez C,Lazaro-Trueba I,Kerr P,Lord CJ,Dexter T,Iravani M,Ashworth A,Silva A

更新日期：2006-02-01 00:00:00

abstract：:Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (...

journal_title：EMBO reports

authors： Chung J,Nakatsu F,Baskin JM,De Camilli P

更新日期：2015-03-01 00:00:00