Abstract:
:Loss of the retinoblastoma protein, pRB, leads to apoptosis, and several results have suggested that this is dependent on the E2F transcription factors. However, so far, the ability of the different E2F family members to contribute to apoptosis is controversial. Here, we show that ectopic expression of E2F3 results in apoptosis in both primary mouse fibroblasts and transgenic mice. Apoptosis induced by E2F3 is associated with the accumulation of E2F1 and, strikingly, we found that E2F3-induced apoptosis is dependent on E2F1. On the basis of these results, we propose that the accumulation of crucial levels of E2F1 activity, and not total E2F activity, is essential for the induction of apoptosis in response to a deregulated pRB pathway. These results are consistent with previous findings that E2F1, but not other E2Fs, can have tumour-suppressing activities.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Lazzerini Denchi E,Helin Kdoi
10.1038/sj.embor.7400452keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
661-8issue
7eissn
1469-221Xissn
1469-3178pii
7400452journal_volume
6pub_type
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