Abstract:
:The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In addition, we show that Gam1 counteracts HDAC1 sumoylation both in vivo and in vitro. Sumoylation of HDAC1 does not seem to be absolutely required for HDAC1 biological activity but is part of a complex regulatory circuit that also includes phosphorylation of the deacetylase. Our data demonstrate that Gam1 is a viral protein that can affect simultaneously two signaling pathways: sumoylation and acetylation.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Colombo R,Boggio R,Seiser C,Draetta GF,Chiocca Sdoi
10.1093/embo-reports/kvf213keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1062-8issue
11eissn
1469-221Xissn
1469-3178pii
kvf213journal_volume
3pub_type
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