Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway.

abstract：:Intercellular communication orchestrates effective immune responses against disease-causing agents. Extracellular vesicles (EVs) are potent mediators of cell-cell communication. EVs carry bioactive molecules, including microRNAs, which modulate gene expression and function in the recipient cell. Here, we show that for...

journal_title：EMBO reports

authors： Fernández-Messina L,Rodríguez-Galán A,de Yébenes VG,Gutiérrez-Vázquez C,Tenreiro S,Seabra MC,Ramiro AR,Sánchez-Madrid F

更新日期：2020-04-03 00:00:00

abstract：:Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector-parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA) knockout approach to determine the function of the mosquito antimicrobial peptide gene Defensin. We injected dsRNA into adul...

journal_title：EMBO reports

authors： Blandin S,Moita LF,Köcher T,Wilm M,Kafatos FC,Levashina EA

更新日期：2002-09-01 00:00:00

abstract：:Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1S616 phosphorylation is significantly reduced in cells and mouse tissues deficient for PINK1, ...

journal_title：EMBO reports

authors： Han H,Tan J,Wang R,Wan H,He Y,Yan X,Guo J,Gao Q,Li J,Shang S,Chen F,Tian R,Liu W,Liao L,Tang B,Zhang Z

更新日期：2020-08-05 00:00:00

abstract：:We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms...

journal_title：EMBO reports

authors： Lingel A,Simon B,Izaurralde E,Sattler M

更新日期：2005-12-01 00:00:00

abstract：:The tumour suppressor ARF (alternative reading frame), which is mutated or silenced in various tumours, has a crucial role in tumour surveillance to suppress unwarranted cell growth and proliferation. ARF has also been linked to the DNA-damage-induced response of p53 because of its ability to inhibit murine double min...

journal_title：EMBO reports

authors： Dominguez-Brauer C,Chen YJ,Brauer PM,Pimkina J,Raychaudhuri P

更新日期：2009-09-01 00:00:00

abstract：:The mechanisms that regulate the transcription of the tumour suppressor genes p53 and IRF-1 are poorly understood. We have characterized a 68-kDa transcription factor, GAAP-1 (gatekeeper of apoptosis activating proteins), encoded by an alternative splice product of the PRDII-BF1 gene, that recognizes a novel regulator...

journal_title：EMBO reports

authors： Lallemand C,Palmieri M,Blanchard B,Meritet JF,Tovey MG

更新日期：2002-02-01 00:00:00

abstract：:Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. ...

journal_title：EMBO reports

authors： Sousa C,Golebiewska A,Poovathingal SK,Kaoma T,Pires-Afonso Y,Martina S,Coowar D,Azuaje F,Skupin A,Balling R,Biber K,Niclou SP,Michelucci A

更新日期：2018-11-01 00:00:00

abstract：:Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis may be critical for controlling diverse biological processes includin...

journal_title：EMBO reports

authors： De Gassart A,Demaria O,Panes R,Zaffalon L,Ryazanov AG,Gilliet M,Martinon F

更新日期：2016-10-01 00:00:00

abstract：:The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library of chromatin regulators. We identified genes involved in chromatin remodeling, sister ch...

journal_title：EMBO reports

authors： Warmerdam DO,Alonso-de Vega I,Wiegant WW,van den Broek B,Rother MB,Wolthuis RM,Freire R,van Attikum H,Medema RH,Smits VA

更新日期：2020-01-07 00:00:00

abstract：:Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...

journal_title：EMBO reports

authors： Munier AI,Doucet D,Perrodou E,Zachary D,Meister M,Hoffmann JA,Janeway CA Jr,Lagueux M

更新日期：2002-12-01 00:00:00

abstract：:The crystal structure of the ligand-binding domain of RARbeta, a suspect tumour suppressor, reveals important features that distinguish it from the two other RAR isotypes. The most striking difference is an extra cavity allowing RARbeta to bind more bulky agonists. Accordingly, we identified a ligand that shows RARbet...

journal_title：EMBO reports

authors： Germain P,Kammerer S,Pérez E,Peluso-Iltis C,Tortolani D,Zusi FC,Starrett J,Lapointe P,Daris JP,Marinier A,de Lera AR,Rochel N,Gronemeyer H

更新日期：2004-09-01 00:00:00

abstract：:We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nasce...

journal_title：EMBO reports

authors： Gold VA,Chroscicki P,Bragoszewski P,Chacinska A

更新日期：2017-10-01 00:00:00

abstract：:Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs interact with the ALTERNATIVE SPLICING COMPETITOR (ASCO) lncRNA. Here, we analyze the effect of ...

journal_title：EMBO reports

authors： Rigo R,Bazin J,Romero-Barrios N,Moison M,Lucero L,Christ A,Benhamed M,Blein T,Huguet S,Charon C,Crespi M,Ariel F

更新日期：2020-05-06 00:00:00

abstract：:The crucial role of ubiquitin signalling in genome-integrity maintenance was first recognized in 1987 by Stefan Jentsch and Alex Varshavsky, who showed that Rad6-the repair protein involved in DNA damage tolerance-is a ubiquitin-conjugating enzyme. Although this discovery inspired extensive research and led to the dis...

journal_title：EMBO reports

authors： Lukas J

更新日期：2010-12-01 00:00:00

abstract：:The energetic metabolism of photosynthetic organisms is profoundly influenced by state transitions and cyclic electron flow around photosystem I. The former involve a reversible redistribution of the light-harvesting antenna between photosystem I and photosystem II and optimize light energy utilization in photosynthes...

journal_title：EMBO reports

authors： Finazzi G,Rappaport F,Furia A,Fleischmann M,Rochaix JD,Zito F,Forti G

更新日期：2002-03-01 00:00:00

abstract：:The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that ...

journal_title：EMBO reports

authors： Gras S,Chaumont V,Fernandez B,Carpentier P,Charrier-Savournin F,Schmitt S,Pineau C,Flament D,Hecker A,Forterre P,Armengaud J,Housset D

更新日期：2007-06-01 00:00:00

abstract：:Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold...

journal_title：EMBO reports

authors： Uhlmann F

更新日期：2009-10-01 00:00:00

abstract：:Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newl...

journal_title：EMBO reports

authors： Camara JE,Breier AM,Brendler T,Austin S,Cozzarelli NR,Crooke E

更新日期：2005-08-01 00:00:00

abstract：:High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. Furthermore, we establish th...

journal_title：EMBO reports

authors： Mu Y,Lou J,Srivastava M,Zhao B,Feng XH,Liu T,Chen J,Huang J

更新日期：2016-01-01 00:00:00

abstract：:The ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated by mammalian IRE1 cannot be fully explained by IRE1's one known, specific RNA target, X box-bi...

journal_title：EMBO reports

authors： Hamid SM,Citir M,Terzi EM,Cimen I,Yildirim Z,Dogan AE,Kocaturk B,Onat UI,Arditi M,Weber C,Traynor-Kaplan A,Schultz C,Erbay E

更新日期：2020-11-02 00:00:00

abstract：:Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we provide a first proof of concept for such a ...

journal_title：EMBO reports

authors： Yosef I,Edry-Botzer L,Globus R,Shlomovitz I,Munitz A,Gerlic M,Qimron U

更新日期：2019-08-01 00:00:00

abstract：:In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 antibody or expression of dominant-negative Rac1N17 led to an inversion ...

journal_title：EMBO reports

authors： Yu W,Shewan AM,Brakeman P,Eastburn DJ,Datta A,Bryant DM,Fan QW,Weiss WA,Zegers MM,Mostov KE

更新日期：2008-09-01 00:00:00

abstract：:RNA modifications represent a novel layer of regulation of gene expression. Functional experiments revealed that N6 -methyladenosine (m6 A) on messenger RNA (mRNA) plays critical roles in cell fate determination and development. m6 A mark also resides in the decoding center of 18S ribosomal RNA (rRNA); however, the bi...

journal_title：EMBO reports

authors： Xing M,Liu Q,Mao C,Zeng H,Zhang X,Zhao S,Chen L,Liu M,Shen B,Guo X,Ma H,Chen H,Zhang J

更新日期：2020-10-05 00:00:00

abstract：:Several mechanisms have been proposed for the synthesis of substrate-linked ubiquitin chains. HECT ligases directly catalyse protein ubiquitination and have been found to non-covalently interact with ubiquitin. We report crystal structures of the Nedd4 HECT domain, alone and in complex with ubiquitin, which show a new...

journal_title：EMBO reports

authors： Maspero E,Mari S,Valentini E,Musacchio A,Fish A,Pasqualato S,Polo S

更新日期：2011-04-01 00:00:00

abstract：:Around 100 researchers gathered at the eighteenth EMBO Conference on 'The Molecular and Developmental Biology of Drosophila', which took place in Crete in June 2012. Whether deconstructing or integrating at the genetic, cellular or organ level, the talks highlighted the synergy of combining methods, approaches and dis...

journal_title：EMBO reports

authors： Miguel-Aliaga I,Oliver B,Teleman AA

更新日期：2012-11-06 00:00:00

abstract：:Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

journal_title：EMBO reports

authors： Harris RE,Ashe HL

更新日期：2011-06-01 00:00:00

abstract：:The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...

journal_title：EMBO reports

authors： Ahuja M,Muallem S

更新日期：2014-03-01 00:00:00

abstract：:Endocytosis and subsequent lysosomal degradation of activated signalling receptors can attenuate signalling. Endocytosis may also promote signalling by targeting receptors to specific compartments. A key step regulating the degradation of receptors is their ubiquitination. Hrs/Vps27p, an endosome-associated, ubiquitin...

journal_title：EMBO reports

authors： Jékely G,Rørth P

更新日期：2003-12-01 00:00:00

abstract：:SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in re...

journal_title：EMBO reports

authors： Saura A,Iribarren PA,Rojas-Barros D,Bart JM,López-Farfán D,Andrés-León E,Vidal-Cobo I,Boehm C,Alvarez VE,Field MC,Navarro M

更新日期：2019-12-05 00:00:00

abstract：:In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to...

journal_title：EMBO reports

authors： Sakamoto K,Furuichi Y,Yamamoto M,Takahashi M,Akimoto Y,Ishikawa T,Shimizu T,Fujimoto M,Takada-Watanabe A,Hayashi A,Mita Y,Manabe Y,Fujii NL,Ishibashi R,Maezawa Y,Betsholtz C,Yokote K,Takemoto M

更新日期：2019-11-05 00:00:00