Abstract:
:Cells suffer necrotic death when exposed to extreme environmental conditions, adverse and excessive stimuli, or when deleterious mutations are encoded in their genetic material. Unlike apoptosis, which involves a highly regulated and elaborate network of biochemical events and cascades, necrosis has been considered generally to be a chaotic decadence process that effects the inexorable demise of cells otherwise not destined to die. This grim prospect is now slowly being overturned, mostly by exciting new findings in two simple model organisms, Caenorhabditis elegans and Drosophila melanogaster. Despite the wide spectrum of necrosis-initiating conditions, evidence is accumulating that execution of necrotic or neurodegenerative cell death may be carried out by a finite common set of mechanisms.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Syntichaki P,Tavernarakis Ndoi
10.1093/embo-reports/kvf138keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
604-9issue
7eissn
1469-221Xissn
1469-3178pii
3/7/604journal_volume
3pub_type
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