Mps1 promotes rapid centromere accumulation of Aurora B.

abstract：:RNA silencing is a complex of mechanisms that regulate gene expression through small RNA molecules. The microRNA (miRNA) pathway is the most common of these in mammals. Genome-encoded miRNAs suppress translation in a sequence-specific manner and facilitate shifts in gene expression during developmental transitions. He...

journal_title：EMBO reports

authors： Svoboda P,Flemr M

更新日期：2010-08-01 00:00:00

abstract：:The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...

journal_title：EMBO reports

authors： Russo A,Goel P,Brace EJ,Buser C,Dickman D,DiAntonio A

更新日期：2019-03-01 00:00:00

abstract：:Transcription is a complex process that integrates the state of the cell and its environment to generate adequate responses for cell fitness and survival. Recent microscopy experiments have been able to monitor transcription from single genes in individual cells. These observations have revealed two striking features:...

journal_title：EMBO reports

authors： Lionnet T,Singer RH

更新日期：2012-04-02 00:00:00

abstract：:Potentially pathogenic bacteria, such as Escherichia coli and Vibrio cholerae, become non-culturable during stasis. The analysis of such cells has been hampered by difficulties in studying bacterial population heterogeneity. Using in situ detection of protein oxidation in single E. coli cells, and using a density-grad...

journal_title：EMBO reports

authors： Desnues B,Cuny C,Grégori G,Dukan S,Aguilaniu H,Nyström T

更新日期：2003-04-01 00:00:00

abstract：:Chromosomal instability (CIN) refers to the rate at which cells are unable to properly segregate whole chromosomes, leading to aneuploidy. Besides its prevalence in cancer cells and postulated implications in promoting tumorigenesis, studies in aneuploidy-prone mouse models uncovered an unanticipated link between CIN ...

journal_title：EMBO reports

authors： Barroso-Vilares M,Macedo JC,Reis M,Warren JD,Compton D,Logarinho E

更新日期：2020-05-06 00:00:00

abstract：:LeuT serves as the model protein for understanding the relationships between structure, mechanism and pharmacology in neurotransmitter sodium symporters (NSSs). At the present time, however, there is a vigorous debate over whether there is a single high-affinity substrate site (S1) located at the original, crystallogr...

journal_title：EMBO reports

authors： Wang H,Gouaux E

更新日期：2012-09-01 00:00:00

abstract：:Sulphatases undergo a unique post-translational modification that converts a highly conserved cysteine located within their active site into formylglycine. This modification is necessary for the catalytic activities of the sulphatases, and it is generated by the protein product of sulphatase-modifying factor 1 (SUMF1)...

journal_title：EMBO reports

authors： Zito E,Fraldi A,Pepe S,Annunziata I,Kobinger G,Di Natale P,Ballabio A,Cosma MP

更新日期：2005-07-01 00:00:00

abstract：:In an attempt to further increase transgene expression levels in plants over and above the enhancement obtained with a 5' untranslated leader intron, three different maize introns were inserted at three different positions within the coding sequence of the luciferase reporter gene. Constructs were transformed into mai...

journal_title：EMBO reports

authors： Bourdon V,Harvey A,Lonsdale DM

更新日期：2001-05-01 00:00:00

abstract：:The cytosolic pathogen sensor RIG-I is activated by RNAs with exposed 5'-triphosphate (5'-ppp) and terminal double-stranded structures, such as those that are generated during viral infection. RIG-I has been shown to translocate on dsRNA in an ATP-dependent manner. However, the precise role of the ATPase activity in R...

journal_title：EMBO reports

authors： Patel JR,Jain A,Chou YY,Baum A,Ha T,García-Sastre A

更新日期：2013-09-01 00:00:00

abstract：:High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. Furthermore, we establish th...

journal_title：EMBO reports

authors： Mu Y,Lou J,Srivastava M,Zhao B,Feng XH,Liu T,Chen J,Huang J

更新日期：2016-01-01 00:00:00

abstract：:The second edition of the EMBO Spatial meeting took place in May 2011 in Engelberg, Switzerland. Although the work presented at the meeting covered a challengingly broad range of topics, it accomplished the rare goal of promoting interactions between cell biologists, neuroscientists, systems biologists and mathematici...

journal_title：EMBO reports

authors： Tzlil S,Kuruvilla R

更新日期：2011-09-01 00:00:00

abstract：:Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newl...

journal_title：EMBO reports

authors： Camara JE,Breier AM,Brendler T,Austin S,Cozzarelli NR,Crooke E

更新日期：2005-08-01 00:00:00

abstract：:Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway and that EVs released from M.tb-infec...

journal_title：EMBO reports

authors： Cheng Y,Schorey JS

更新日期：2019-03-01 00:00:00

abstract：:Global climate change and the increasing human population require crop varieties with higher yield and draught resistance. But meeting both goals is not an easy task for breeders and plant science. ...

journal_title：EMBO reports

authors： Moshelion M

更新日期：2020-11-29 00:00:00

abstract：:Proteins of the Imp4/Brix superfamily are involved in ribosomal RNA processing, an essential function in all cells. We report the first structure of an Imp4/Brix superfamily protein, the Mil (for Methanothermobacter thermautotrophicus Imp4-like) protein (gene product Mth680), from the archaeon M. thermautotrophicus. T...

journal_title：EMBO reports

authors： Ng CL,Waterman D,Koonin EV,Antson AA,Ortiz-Lombardía M

更新日期：2005-02-01 00:00:00

abstract：:COVID-19 highlighted the importance of science and scientists to produce vaccines, cures and diagnostics. But scientists need to be careful not to overpromise on what they can deliver. ...

journal_title：EMBO reports

authors： Gannon F

更新日期：2020-11-05 00:00:00

abstract：:It has been suggested that DNA methylation/demethylation is involved in regulating V(D)J rearrangement. Although methylated DNA is thought to induce an inaccessible chromatin structure, it is unclear whether DNA methylation can directly control V(D)J recombination independently of chromatin structure. In this study, w...

journal_title：EMBO reports

authors： Nakase H,Takahama Y,Akamatsu Y

更新日期：2003-08-01 00:00:00

abstract：:Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, eac...

journal_title：EMBO reports

authors： Klosowiak JL,Focia PJ,Chakravarthy S,Landahl EC,Freymann DM,Rice SE

更新日期：2013-11-01 00:00:00

abstract：:Although eukaryotic G-protein coupled receptor (GPCR) systems are well known for their ability to detect and mediate rapid responses to extracellular signals, the full range of stimuli to which they respond may not yet have been identified. Activation of GPCRs by hormones, pheromones, odorants, neurotransmitters, ligh...

journal_title：EMBO reports

authors： Versele M,Lemaire K,Thevelein JM

更新日期：2001-07-01 00:00:00

abstract：:The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt...

journal_title：EMBO reports

authors： Mendes CS,Arama E,Brown S,Scherr H,Srivastava M,Bergmann A,Steller H,Mollereau B

更新日期：2006-09-01 00:00:00

abstract：:Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs interact with the ALTERNATIVE SPLICING COMPETITOR (ASCO) lncRNA. Here, we analyze the effect of ...

journal_title：EMBO reports

authors： Rigo R,Bazin J,Romero-Barrios N,Moison M,Lucero L,Christ A,Benhamed M,Blein T,Huguet S,Charon C,Crespi M,Ariel F

更新日期：2020-05-06 00:00:00

abstract：:Mitochondrial respiration generates an electrochemical proton gradient across the mitochondrial inner membrane called protonmotive force (PMF) to drive diverse functions and synthesize ATP. Current techniques to manipulate the PMF are limited to its dissipation; yet, there is no precise and reversible method to increa...

journal_title：EMBO reports

authors： Berry BJ,Trewin AJ,Milliken AS,Baldzizhar A,Amitrano AM,Lim Y,Kim M,Wojtovich AP

更新日期：2020-04-03 00:00:00

abstract：:Scrapie, bovine spongiform encephalopathy and chronic wasting disease are orally communicable, transmissible spongiform encephalopathies (TSEs). As zoonotic transmissions of TSE agents may pose a risk to human health, the identification of reservoirs for infectivity in animal tissues and their exclusion from human con...

journal_title：EMBO reports

authors： Thomzig A,Kratzel C,Lenz G,Krüger D,Beekes M

更新日期：2003-05-01 00:00:00

abstract：:Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP activity, inducing grow...

journal_title：EMBO reports

authors： Ito Y,Oinuma I,Katoh H,Kaibuchi K,Negishi M

更新日期：2006-07-01 00:00:00

abstract：:The activation and transformation model of vertebrate nervous system formation posits that neural tissue is initially induced, or activated, with anterior forebrain character. Once established, a subset is then transformed into the more posterior midbrain, hindbrain, and spinal cord by signals emanating from the poste...

journal_title：EMBO reports

authors： Al Anber A,Martin BL

更新日期：2019-08-01 00:00:00

abstract：:The EMBO/EMBL symposium 'Human Variation: Cause and Consequence' highlighted advances in understanding the molecular basis of human genetic variation and its myriad implications for biology, human origins and disease. As high-throughput sequencing allows us to define genetic variation and its functional consequences a...

journal_title：EMBO reports

authors： Knight JC

更新日期：2010-09-01 00:00:00

abstract：:The major DNA methyltransferase, Dnmt1, associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand. In view of the slow kinetics of Dnmt1 in vitro versus the fast progression of the replication fork, we have tested whether Dnmt1 associates with chromatin beyond...

journal_title：EMBO reports

authors： Easwaran HP,Schermelleh L,Leonhardt H,Cardoso MC

更新日期：2004-12-01 00:00:00

abstract：:Acetaminophen/paracetamol-induced liver failure--which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption--is exacerbated by fasting. As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residues, we investigat...

journal_title：EMBO reports

authors： Lu Z,Bourdi M,Li JH,Aponte AM,Chen Y,Lombard DB,Gucek M,Pohl LR,Sack MN

更新日期：2011-07-01 00:00:00

abstract：:The receptor-evoked Ca(2+) signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca(2+) ([Ca(2+)]c) oscillations result in mitochondrial Ca(2+) ([Ca(2+)]m) oscillations, while large and sustained [Ca(2+)]c increase results in a pathologic increase in basal [Ca(2+)]m and in Ca(2+) accumulation. The...

journal_title：EMBO reports

authors： Ahuja M,Muallem S

更新日期：2014-03-01 00:00:00

abstract：:Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To e...

journal_title：EMBO reports

authors： Harris RE,Ashe HL

更新日期：2011-06-01 00:00:00